Volumetric Growth Rate of Stage I Lung Cancer prior to Treatment: Serial CT Scanning

Winer-Muram, Helen T.; Jennings, S. Gregory; Tarver, Robert D.; Aisen, Alex M.; Tann, Mark; Conces, Dewey J.; Meyer, Cristopher A.

doi:10.1148/radiol.2233011026

Cited by 132 publications

(106 citation statements)

References 26 publications

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“…Other studies have looked at DTs in lung cancer (6)(7)(8)(9)(10). Several studies have compared DT in squamous cell carcinoma (SCC) and AC, showing significantly shorter DT in SCC than in AC (6-8).…”

Section: Discussionmentioning

confidence: 99%

Doubling Times and CT Screen–Detected Lung Cancers in the Pittsburgh Lung Screening Study

Wilson¹,

Ryan

Fuhrman

et al. 2012

Am J Respir Crit Care Med

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Rationale: As computed tomography (CT) screening for lung cancer becomes more widespread, volumetric analyses, including doubling times, of CT-screen detected lung nodules and lung cancers may provide useful information in the follow-up and management of CT-detected lung nodules and cancers. Objectives: To analyze doubling times in CT screen detected lung cancers and compare prevalent and nonprevalent cancers and different cell types on non small cell lung cancer. Methods: We performed volumetric and doubling time analysis on 63 non-small cell lung cancers detected as part of the Pittsburgh Lung Screening Study using a commercially available VITREA 2 workstation and VITREA VITAL nodule segmentation software. Measurements and Main Results: Doubling times (DT) were divided into three groups: rapid (DT , 183 d), typical (DT 183-365 d), and slow (DT . 365 d). Adenocarcinoma/bronchioloalveolar carcinoma comprised 86.7% of the slow DT group compared with 20% of the rapid DT group. Conversely, squamous cell cancer comprised 60% of the rapid DT group compared with 3.3% of the slow DT group. Twenty-eight of 42 (67%) prevalent and 2 of 21 (10%) nonprevalent cancers were in the slow DT group (P , 0.0001; Fisher's exact test). Twenty-four of 32 (75%) prevalent and 1 of 11 (9%) nonprevalent adenocarcinomas were in the slow DT group (P , 0.0002; Fisher's exact test). Conclusions: Volumetric analysis of CT-detected lung cancers is particularly useful in AC/BAC. Prevalent cancers have a significantly slower DT than nonprevalent cancers and a higher percentage of adenocarcinoma/bronchioloalveolar carcinoma. These results should affect the management of indeterminant lung nodules detected on screening CT scans.Keywords: lung cancer; doubling times; lung cancer screening Computed tomography (CT) screening for lung cancer has been under study for over a decade. With the publication of results from the National Lung Screening Trial (NLST) (1), CT screening for lung cancer may become widespread. We have accumulated over 150 lung cancers as part of the Pittsburgh Lung Screening Study (PLuSS), which started enrolling subjects in 2002 (2). Although there have been several studies of volumetric evaluation of lung nodule doubling times (DTs) for differentiating benign versus malignant pulmonary nodules (3-5), there is less information about DTs in screening-detected lung cancers. We present software volumetric evaluation of DTs in 63 non-small cell lung cancers (NSCLCs) from PLuSS and compare the doubling times in prevalent and nonprevalent cancers. METHODSPLuSS involved 3,642 subjects and was approved by the Institutional Review Board of the University of Pittsburgh. Written informed consent was obtained from all participants, and the study was compliant with the Health Insurance Portability and Accountability Act. At the time of this study, 148 lung cancers had been diagnosed; 63 were suitable for volumetric nodule analysis. CT Imaging and Nodule Classification ProtocolCT scans evaluated for volumetric analysis included lung cancer scre...

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Section: Discussionmentioning

confidence: 99%

Doubling Times and CT Screen–Detected Lung Cancers in the Pittsburgh Lung Screening Study

Wilson¹,

Ryan

Fuhrman

et al. 2012

Am J Respir Crit Care Med

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show abstract

“…. APn) [13]. Saline volume was calculated according to tumor volume (every 1 cm³ was injected with 1ml hot isotonic saline to make thermal effect reach every part of the tumor, in group A or temperate saline in group B).…”

Section: -Fiberoptic Bronchoscopy (Pentax Fb 19 Tv Pentax Companymentioning

confidence: 99%

Hot Saline Thermoablation of Peripheral Non Small Cell Lung Cancer safety and Efficacy: a Pilot Study

MK¹,

Hewidy²

2017

IJRDM

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“…Given the sensibility of the CT, it is possible to make a second measurement in a short period, inclusively in the range below 30 days, and surprise the nodules with doubling time in the spectrum of growing of neoplastic disorders, indicating, so, its resection (Winer-Muram et al, 2002). Classically, doubling times inferior to 45 days have been associated to inflammatory processes and those ranging from 45 to 450 days have been associated to neoplasm (Nathan et al, 1962).…”

mentioning

confidence: 99%

Informatics and Computerized Tomography Aiding Detection and Diagnosis of Solitary Lung Cancer

Silva¹,

Paiva²,

Nunes³

et al. 2011

Theory and Applications of CT Imaging and Analysis

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Volumetric Growth Rate of Stage I Lung Cancer prior to Treatment: Serial CT Scanning

Abstract: Comparison of tumor volumes at serial CT examinations reveals a very wide range of growth rates. Some tumors grow so slowly that biopsy is required to prove they are malignant.

Cited by 132 publications

References 26 publications

Doubling Times and CT Screen–Detected Lung Cancers in the Pittsburgh Lung Screening Study

Doubling Times and CT Screen–Detected Lung Cancers in the Pittsburgh Lung Screening Study

Hot Saline Thermoablation of Peripheral Non Small Cell Lung Cancer safety and Efficacy: a Pilot Study

Informatics and Computerized Tomography Aiding Detection and Diagnosis of Solitary Lung Cancer

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