Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine

Bılgıç, Başar; Kocaman, Gulsen; Arslan, Ali Bilgin; Noyan, Handan; Sherifov, Resul; Alkan, Alpay; Asıl, Talip; Parman, Yeşim; Baykan, Betül

doi:10.1177/0333102415588328

Cited by 56 publications

(60 citation statements)

References 59 publications

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“…Bilgic et al (2016) found smaller brainstem volumes in migraine patients relative to healthy controls but no correlation between brainstem volume and clinical variables, such as disease duration and MIDAS scores. Positron emission tomography (PET) imaging of migraine patients during migraine attacks have found stronger functional activation in the periaqueductal gray (Weiller et al, 1995) stronger activation in the dorsolateral pons (Afridi et al, 2005) and stronger functional activation in midbrain regions (Weiller et al, 1995).…”

Section: Discussionmentioning

confidence: 62%

“…In a recent volumetric study, Bilgic et al demonstrated less brainstem volume in chronic migraine patients relative to healthy control subjects (Bilgic et al, 2016). Similarly, results by Jin et al demonstrate less cerebellar and brainstem density in migraine patients without aura relative to healthy controls using voxel-based morphometry (Jin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Structural alterations of the brainstem in migraine

Chong

Plasencia

Schwedt

2017

NeuroImage: Clinical

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Atypical brainstem modulation of pain might contribute to changes in sensory processing typical of migraine. The study objective was to investigate whether migraine is associated with brainstem structural alterations that correlate with this altered pain processing.MRI T1-weighted images of 55 migraine patients and 58 healthy controls were used to: (1) create deformable mesh models of the brainstem that allow for shape analyses; (2) calculate volumes of the midbrain, pons, medulla and the superior cerebellar peduncles; (3) interrogate correlations between regional brainstem volumes, cutaneous heat pain thresholds, and allodynia symptoms.Migraineurs had smaller midbrain volumes (healthy controls = 61.28 mm3, SD = 5.89; migraineurs = 58.80 mm3, SD = 6.64; p = 0.038), and significant (p < 0.05) inward deformations in the ventral midbrain and pons, and outward deformations in the lateral medulla and dorsolateral pons relative to healthy controls. Migraineurs had a negative correlation between ASC-12 allodynia symptom severity with midbrain volume (r = − 0.32; p = 0.019) and a positive correlation between cutaneous heat pain thresholds with medulla (r = 0.337; p = 0.012) and cerebellar peduncle volumes (r = 0.435; p = 0.001).Migraineurs with greater symptoms of allodynia have smaller midbrain volumes and migraineurs with lower heat pain thresholds have smaller medulla and cerebellar peduncles. The brainstem likely plays a role in altered sensory processing in migraine and brainstem structure might reflect severity of allodynia and hypersensitivity to pain in migraine.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Structural alterations of the brainstem in migraine

Chong

Plasencia

Schwedt

2017

NeuroImage: Clinical

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“…For that reason, sustained prolongation of STD in CM may arise from unremitting cellular injury in the brainstem and basal ganglia, in relation to frequent migraine attacks. In support of latter notion, impaired functional connectivity among, PAG, thalamus, cerebellum, insula, and other cortical areas as well as volumetric alterations including cortex, PAG, brainstem, and cerebellum were shown in migraine …”

Section: Discussionmentioning

confidence: 55%

“…In support of latter notion, impaired functional connectivity among, PAG, thalamus, cerebellum, insula, and other cortical areas as well as volumetric alterations including cortex, PAG, brainstem, and cerebellum were shown in migraine. 25,26 The processing of STD activates various brain structures including the ones already implicated in migraine pathophysiology such as sensorimotor cortex, insula, basal ganglia, substantia nigra, thalamus, and cerebellum. 20 Therefore, the STD test has an advantage to screen all of the above structures and may reveal temporary or persistent dysfunction in EM or CM respectively.…”

Section: Discussionmentioning

confidence: 99%

Chronic Migraine Is Associated With Sustained Elevation of Somatosensory Temporal Discrimination Thresholds

et al. 2016

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“…Our results indicated that a decreased volume of cerebellum correlate with increased migraine duration, and this decreased cerebellum volume was statistically significant at longer than five years migraine patients. Bilgiç et al (2015) reported a significant reduction in the infratentorial region and the volume of cerebellum with migraine patients, but it is not known whether there were structural changes [11]. This relationship between a migraine and decrease cerebellum volume leads to cognitive and motor function loss over time.…”

Section: Discussionmentioning

confidence: 99%

Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients

Demir¹,

Bayram²,

Aytürk³

et al. 2016

CIM

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Purpose: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. Methods: This work was conducted with cooperation of the Turgut Özal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J. Data were analyzed using the planimetric method. Results: Cerebrum, cerebellum and corpus callosum volume were calculated for all subjects. The footprints of the callosum were as follows: healthy control subjects, new patients and 1-year patients: 12.8%, 5 years: 11.7% and more than 10 years: 10.7%. The cerebrum volume was as follows: healthy control subjects: 1152 cm3, 5-10 years: 1102 cm3 and more than 10 years: 1002 cm3. Discussion: The results of our study showed atrophy in the cerebrum, cerebellum and corpus callosum of chronic migraine patients. This atrophy was greater in the patients with aura migraines. Conclusion: Our study confirmed that a migraine is an episodic disease that seriously affects the CNS.

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Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine

Cited by 56 publications

References 59 publications

Structural alterations of the brainstem in migraine

Structural alterations of the brainstem in migraine

Chronic Migraine Is Associated With Sustained Elevation of Somatosensory Temporal Discrimination Thresholds

Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients

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