Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study

Simon, Tony J.; Ding, Lijun; Bish, Joel P.; McDonald‐McGinn, Donna M.; Zackai, Elaine H.; Gee, James C.

doi:10.1016/j.neuroimage.2004.11.018

Cited by 178 publications

(215 citation statements)

References 62 publications

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“…Differences between the 22q11.2DS cohort studied here that were not detected in our previous analyses with smaller number of subjects included decreased occipital lobe and cerebellar GM and WM volumes. Decrease in volumes in the occipital lobe and cerebellum were reported in other studies of children with 22q11.2DS (Campbell et al, 2006;Simon et al, 2005).…”

Section: Brain Tissue Volumes At Baselinesupporting

confidence: 74%

“…Total brain volume is decreased by 8.5%-11% and there are extensive regional abnormalities in both gray matter (GM) and white matter (WM) volumes (Eliez et al, 2000;Kates et al, 2001;Simon et al, 2005). Frontal lobe grey and white matter volumes are relatively increased while posterior cortical regions including parietal and occipital grey and white matter volumes are reduced (Campbell et al, 2006;Eliez et al, 2000;Kates et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are aberrations of posterior fossa anatomy, most notably cerebellar grey and white matter volume reductions (Bish et al, 2006;. Abnormal volumes have also been reported for other brain regions, including enlarged volumes of ventricular cerebrospinal fluid (CSF), caudate nucleus, and amygdala (Campbell et al, 2006;Eliez et al, 2002;Kates et al, 2006;Simon et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…However, since this is the first comparative longitudinal study of brain development in 22q11.2DS, we could not test hypotheses based on prior information about neurodevelopmental trajectories in this disorder. Accordingly, we chose to focus on the development of candidate brain regions that were previously reported to be abnormal in cross-sectional studies of both 22q11.2DS (Campbell et al, 2006;Chow et al, 2002;Eliez et al, 2002;Kates et al, 2006;Simon et al, 2005;van Amelsvoort et al, 2004) and schizophrenia (reviewed in (DeLisi et al, 2006;Shenton et al, 2001). Thus we analyzed change in volume of the cerebral lobes, superior temporal gyrus (STG), ventricular CSF, cerebellum, amygdala, hippocampus, and caudate nucleus.…”

Section: Introductionmentioning

confidence: 99%

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Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

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Penniman

et al. 2007

Schizophrenia Research

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The 22q11.2 deletion syndrome (22q11.2DS) is associated with very high rates of schizophrenialike psychosis and cognitive deficits. Here we report the results of the first longitudinal study assessing brain development in individuals with 22q11.2DS. Twenty-nine children with 22q11.2DS and 29 age and gender matched controls were first assessed during childhood or early adolescence; Nineteen subjects with 22q11.2DS and 18 controls underwent follow-up during late adolescenceearly adulthood. The 22q11.2DS subjects showed greater longitudinal increase in cranial and cerebellar white matter, superior temporal gyrus, and caudate nucleus volumes. They also had a more robust decrease in amygdala volume. Verbal IQ (VIQ) scores of the 22q11.2DS group that developed psychotic disorders declined significantly between assessments. Decline in VIQ in 22q11.2DS was associated with more robust reduction of left cortical grey matter volume. No volumetric differences were detected between psychotic and nonpsychotic subjects with 22q11.2DS. Brain maturation associated with verbal cognitive development in 22q11.2DS varies from that observed in healthy controls. Further longitudinal studies are likely to elucidate brain developmental trajectories in 22q11.2DS and their association to psychotic disorders and cognitive deficits in this population.

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Section: Brain Tissue Volumes At Baselinesupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Gothelf

Penniman

et al. 2007

Schizophrenia Research

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“…They can be compared across individuals at every voxel after alignment (e.g. 30 ), or averaged across tracts after tractography-based tract segmentation (e.g. 31 ).…”

Section: Microstructure -Mri At the Microscopic Levelmentioning

confidence: 99%

Studying neuroanatomy using MRI

et al. 2017

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The study of neuroanatomy using imaging enables key insights into how our brains function, are shaped by genes and environment, and change with development, aging, and disease. Developments in MRI acquisition, image processing, and data modelling have been key to these advances. However, MRI provides an indirect measurement of the biological signals we aim to investigate. Thus, artifacts and key questions of correct interpretation can confound the readouts provided by anatomical MRI. In this review we provide an overview of the methods for measuring macro-and mesoscopic structure and inferring microstructural properties; we also describe key artefacts and confounds that can lead to incorrect conclusions. Ultimately, we believe that, though methods need to improve and caution is required in its interpretation, structural MRI continues to have great promise in furthering our understanding of how the brain works.

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Visuospatial Attention in Children

Chatterjee¹

2008

Arch Neurol

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Volumetric, connective, and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: an integrative study

Cited by 178 publications

References 62 publications

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Studying neuroanatomy using MRI

Visuospatial Attention in Children

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