Volumetric and Shape Analysis of the Thalamus and Striatum in Amnestic Mild Cognitive Impairment

Leh, Sandra E.; Kälin, Andrea M.; Schroeder, Clemens; Park, Min Tae M.; Chakravarty, M. Mallar; Freund, Patrick; Gietl, Anton; Riese, Florian; Kollias, Spyros; Höck, Christoph; Michels, Lars

doi:10.3233/jad-150080

Cited by 16 publications

(18 citation statements)

References 76 publications

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“…The contractions found in the pulvinar and dorsal aspects of the VP in MCI-CB are consistent with contractions that have been identified in amnestic MCI by an earlier study of our group (Leh et al, 2015). Additionally, the authors have documented contractions in regions that remained unaffected in the present MCI-CB sample such as the VL and lateral posterior nuclei.…”

Section: Discussionsupporting

confidence: 92%

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

Kälin

Park

Chakravarty

et al. 2017

Front. Aging Neurosci.

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Efficacy of future treatments depends on biomarkers identifying patients with mild cognitive impairment at highest risk for transitioning to Alzheimer's disease. Here, we applied recently developed analysis techniques to investigate cross-sectional differences in subcortical shape and volume alterations in patients with stable mild cognitive impairment (MCI) (n = 23, age range 59–82, 47.8% female), future converters at baseline (n = 10, age range 66–84, 90% female) and at time of conversion (age range 68–87) compared to group-wise age and gender matched healthy control subjects (n = 23, age range 61–81, 47.8% female; n = 10, age range 66–82, 80% female; n = 10, age range 68–82, 70% female). Additionally, we studied cortical thinning and global and local measures of hippocampal atrophy as known key imaging markers for Alzheimer's disease. Apart from bilateral striatal volume reductions, no morphometric alterations were found in cognitively stable patients. In contrast, we identified shape alterations in striatal and thalamic regions in future converters at baseline and at time of conversion. These shape alterations were paralleled by Alzheimer's disease like patterns of left hemispheric morphometric changes (cortical thinning in medial temporal regions, hippocampal total and subfield atrophy) in future converters at baseline with progression to similar right hemispheric alterations at time of conversion. Additionally, receiver operating characteristic curve analysis indicated that subcortical shape alterations may outperform hippocampal volume in identifying future converters at baseline. These results further confirm the key role of early cortical thinning and hippocampal atrophy in the early detection of Alzheimer's disease. But first and foremost, and by distinguishing future converters but not patients with stable cognitive abilities from cognitively normal subjects, our results support the value of early subcortical shape alterations and reduced hippocampal subfield volumes as potential markers for the early detection of Alzheimer's disease.

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Section: Discussionsupporting

confidence: 92%

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

Kälin

Park

Chakravarty

et al. 2017

Front. Aging Neurosci.

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“…Unlike our previous analyses using subcortical overall volumes, we found that subcortical regional PiB retention values were associated with the surface of the bilateral hippocampus and thalamus and the right pallidum. Surface displacement associated with hippocampal Aβ owed exclusively to local volume changes; these changes were located bilaterally in regions roughly corresponding to the CA1 subfield and subiculum and were more prominent in the left hippocampus, which is in line with previous shape-based investigations in AD and MCI patients reporting abnormal surface in the hippocampus (Csernansky et al, 2000;Leh et al, 2016;Lindberg et al, 2012). Lateral deformation of the hippocampus, which we also found in our study, was reported to predict cognitive decline and dementia onset in cognitively normal individuals (Csernansky et al, 2005;Zanchi, Giannakopoulos, Borgwardt, Rodriguez, & Haller, 2017).…”

Section: Discussionsupporting

confidence: 92%

“…A vertex‐based surface approach was used to investigate Aβ‐associated local surface changes in subcortical structures and whether these changes related more to local volume or shape. Surface‐based approaches have proven efficient in the detection of subtle surface abnormalities in subcortical structures in AD, MCI, and cognitively normal individuals (Csernansky et al, ; de Flores et al, ; Kalin et al, ; Leh et al, ; Schroeder et al, ). Unlike our previous analyses using subcortical overall volumes, we found that subcortical regional PiB retention values were associated with the surface of the bilateral hippocampus and thalamus and the right pallidum.…”

Section: Discussionmentioning

confidence: 99%

Subcortical amyloid load is associated with shape and volume in cognitively normal individuals

Rahayel

Bocti

Dupont

et al. 2019

Human Brain Mapping

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Amyloid‐beta (Aβ) deposition is one of the main hallmarks of Alzheimer's disease. The study assessed the associations between cortical and subcortical 11C‐Pittsburgh Compound B (PiB) retention, namely, in the hippocampus, amygdala, putamen, caudate, pallidum, and thalamus, and subcortical morphology in cognitively normal individuals. We recruited 104 cognitive normal individuals who underwent extensive neuropsychological assessment, PiB–positron emission tomography (PET) scan, and 3‐T magnetic resonance imaging (MRI) acquisition of T1‐weighted images. Global, cortical, and subcortical regional PiB retention values were derived from each scan and subcortical morphology analyses were performed to investigate vertex‐wise local surface and global volumes, including the hippocampal subfields volumes. We found that subcortical regional Aβ was associated with the surface of the hippocampus, thalamus, and pallidum, with changes being due to volume and shape. Hippocampal Aβ was marginally associated with volume of the whole hippocampus as well as with the CA1 subfield, subiculum, and molecular layer. Participants showing higher subcortical Aβ also showed worse cognitive performance and smaller hippocampal volumes. In contrast, global and cortical PiB uptake did not associate with any subcortical metrics. This study shows that subcortical Aβ is associated with subcortical surface morphology in cognitively normal individuals. This study highlights the importance of quantifying subcortical regional PiB retention values in these individuals.

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“…Finally, we performed a linear regression of the right pulvinar (rPul) volume and years consuming cocaine, with total brain volume, age and sex as covariates. A liberal FDR threshold was chosen due to the small sample size, the high variability of results in previous studies, and consistency with previous reports on shape analysis 38,44 . For visualization purposes only, we created corrected volume variables using the residuals of the linear model.…”

Section: Discussionmentioning

confidence: 85%

The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging

Garza‐Villarreal

Chakravarty

Hansen

et al. 2016

Preprint

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The striatum and thalamus are subcortical structures intimately involved in addiction. The morphology and microstructure of these have been studied in murine models of cocaine addiction (CA), showing an effect of drug use, but also chronological age in morphology. Human studies using non-invasive magnetic resonance imaging (MRI) have shown inconsistencies in volume changes, and have also shown an age effect. In this exploratory study, we used MRI-based volumetric and novel shape analysis, as well as a novel fast diffusion kurtosis imaging sequence to study the morphology and microstructure of striatum and thalamus in crack CA compared to matched healthy controls (HCs), while investigating the effect of age and years of cocaine consumption. We did not find significant differences in volume and mean kurtosis (MKT) between groups. However, we found significant contraction of nucleus accumbens in CA compared to HCs. We also found significant age-related changes in volume and MKT of CA in striatum and thalamus that are different to those seen in normal aging. Interestingly, we found different effects and contributions of age and years of consumption in volume, displacement and MKT changes, suggesting that each measure provides different but complementing information about morphological brain changes, and that not all changes are related to the toxicity or the addiction to the drug. Our findings suggest that the use of finer methods and sequences provides complementing information about morphological and microstructural changes in CA, and that brain alterations in CA are related cocaine use and age differently.Translational Psychiatry (2017) 7, e1122; doi:10.1038/tp.2017.92; published online 9 May 2017 INTRODUCTIONThe striatum and thalamus are subcortical structures greatly affected in the physiopathology of cocaine addiction in animal models and possibly in humans.1 Studies in animal models show microstructural changes in striatal medium spiny neurons, as well as striatal indirect, direct and thalamo-striatal pathways.2 Using neuroimaging in mice, Wheeler et al.3 showed volumetric reduction in ventral and posterior striatum, and expansion in the dorsal striatum in a cocaine addiction model. However, noninvasive neuroimaging studies in human cocaine addicts (CAs) have shown inconsistent and conflicting neuroanatomical abnormalities in striatum and thalamus.

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Volumetric and Shape Analysis of the Thalamus and Striatum in Amnestic Mild Cognitive Impairment

Cited by 16 publications

References 76 publications

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients

Subcortical amyloid load is associated with shape and volume in cognitively normal individuals

The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging

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