Volumetric and Histological Findings in Intra-Abdominal Testes Before and After Division of Spermatic Vessels

Rosito, Nicolino Cesar; Koff, Walter José; Oliveira, Taismar Liliane Da Silva; Cerski, Carlos T. Z.; Salle, João L. Pippi

doi:10.1097/01.ju.0000125242.43762.be

Cited by 42 publications

(25 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement to other authors [11,17,22], we believe that checking the position and size of the testis on follow-up physical examination is a reliable sign of a good vascular supply to the testis. We are persuaded that the testes should totally disappear within 2 months from the surgery if a necrosis should occur; thus, a follow-up of 6 months is fair enough to spot such an event.…”

Section: Discussionsupporting

confidence: 90%

Is the Fowler-Stephens procedure still indicated for the treatment of nonpalpable intraabdominal testis?

Daher

Nabbout

Feghali

et al. 2009

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Is the Fowler-Stephens procedure still indicated for the treatment of nonpalpable intraabdominal testis?

Daher

Nabbout

Feghali

et al. 2009

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…Its overall success rate is 87.9% [7] . Unfortunately, a 4-30% rate of testicular atrophy has been reported after two-stage FSO [5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

“…The advantage of this approach is that the undescended testis is allowed to develop collateral blood flow through the deferential artery with a significantly reduced risk of vasospasm. Although a high degree of success can be obtained with two-stage FSO [4] , the results of two-stage FSO remain unsatisfactory due to detrimental consequences on the testes [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

Çakan¹,

Yılmazer

Çakan

et al. 2008

Urol Int

View full text Add to dashboard Cite

Aims: Two-stage Fowler-Stephens orchiopexy has been accompanied by testicular atrophy in some cases but neither of the mechanisms responsible for testicular injury are clear, nor is there an effective agent that might prevent this injury. In this study we aimed to investigate the long-term effects of naloxone, a morphine antagonist, on testicular histopathology and oxidative stress after spermatic vessel ligation (SVL) in rats. Methods: 32 prepubertal rats were randomly divided into four equal groups: group 1: control (only bilateral orchiectomies were performed); group 2: sham-operated group; group 3: SVL, and group 4: SVL+naloxone (1 mg/kg twice daily for 1 month). One month postoperatively, bilateral orchiectomies were performed to evaluate histopathologic findings and measurement of malondialdehyde (MDA) and nitric oxide (NO) levels. Results: Considering group 3, left SVL resulted in significant tissue damage in both testes, more severe in the ipsilateral testis. The SVL resulted in a significant increase in testicular MDA levels of both testes in this group (p < 0.05). While the ipsilateral testicular NO levels of groups 2 and 3 were significantly lower than of group 1 (p < 0.05), the contralateral testicular NO levels of all these groups were similar. After naloxone therapy, while there was no significant improvement in ipsilateral testicular histopathology (p > 0.05), the contralateral testicular histopathology improved significantly (p < 0.05). However, naloxone did not change either testicular MDA or NO levels. Conclusions: The SVL led to bilateral testicular injury, and oxidative stress may be a reason for this injury. Naloxone significantly improved contralateral testicular injury without showing any antioxidative effect.

show abstract

“…Fowler-Stephens stage I orchidopexy has shown significant reduction in the number of spermatogonia and seminiferous tubules 6 months after SVLD [34]. It may be ethically unjustifiable to perform testicular biopsy during a Fowler-Stephens procedure and/or at a date after a Fowler-Stephens procedure to study the effects of SVLD on testis.…”

Section: Introductionmentioning

confidence: 98%

Prepubertal unilateral spermatic vessel ligation decreases haploid cell population of ipsilateral testis postpubertally in rats

et al. 2005

View full text Add to dashboard Cite

DNA flow cytometry is a sensitive and rapid technique to evaluate the germ cell maturation of testis. The haploid cell population of testis specifically denotes testicular maturation. High ligation of spermatic vessels (HLSV) and low ligation of spermatic vessels (LLSV) have been described in the surgical treatment of high undescended testis. Estimation of germ cell population of testis after these maneuvers has not been performed so far by DNA flow cytometry; hence this study was designed. Thirty male rats, aged 30 days, were randomized into three groups. Group I underwent sham surgery; group II underwent unilateral HLSV-ligation and division of main spermatic vessels, similar to the Fowler-Stephens technique; and group III underwent unilateral LLSV-ligation and division of main spermatic vessels close to the testis, similar to the Koff and Sethi technique. Thirty days later, the ipsilateral testes were harvested, and haploid, diploid, and tetraploid cells were counted by DNA flow cytometry. The mean (+/-SD) percentage of the haploid cell population was 68.7+/-4.8, 49.3+/-6.5, and 50.8+/-6.4 in groups I, II, and III, respectively. There was a significant (p<0.05) decrease in haploid cell population between groups I and II and between groups I and III. However, there was no significant difference between groups II and III. In conclusion, prepubertal HLSV as well as LLSV decreases the haploid cell population of ipsilateral testis in rats. LLSV has no advantage over HLSV.

show abstract

Volumetric and Histological Findings in Intra-Abdominal Testes Before and After Division of Spermatic Vessels

Cited by 42 publications

References 16 publications

Is the Fowler-Stephens procedure still indicated for the treatment of nonpalpable intraabdominal testis?

Is the Fowler-Stephens procedure still indicated for the treatment of nonpalpable intraabdominal testis?

Effect of Naloxone on Oxidative Stress and Testicular Injury due to Spermatic Vessel Ligation of Rat Testis

Prepubertal unilateral spermatic vessel ligation decreases haploid cell population of ipsilateral testis postpubertally in rats

Contact Info

Product

Resources

About