Volumetric and aggregation properties of metformin hydrochloride in methanol in temperature range of (288.15–318.15) K

Shakeel, Muhammad; Mahmood, Khalid

doi:10.1016/j.surfin.2020.100852

Cited by 1 publication

(5 citation statements)

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“…The densities of drug solutions, measured at specified temperatures, were used to calculate apparent molar volume ( V ϕ ) with the help of Equation . [ 14,15 ]

V_{ϕ} = M_{2} / ρ + ((), ρ_{0} - ρ) / ((), ρ_{0} italicρm)

In this equation, M 2 represents molar mass of drug in units of kg mol −1 ; ρ and ρ 0 represent densities of drug solutions and pure solvent, respectively, in terms of kg m −3 , while m is molality (mol kg −1 ) of solutions.…”

Section: Resultsmentioning

confidence: 99%

“…[ 16 ] Decrease in the value of V ϕ with concentration of drug shows a compression in the volume due to change in mean distance and hydrophobic interaction between drug and solvent molecules. [ 15 ] An increase in values of V ϕ with temperature represents decrease in hydrophilicity caused by the removal of water molecules present in secondary solvated layer, which increases the volume of solution and increases V ϕ . [ 17,18 ]…”

Section: Resultsmentioning

confidence: 99%

“…The degree of packing of drug molecules at the surface is expressed by the minimum area its molecule occupies at air–solution interface and is calculated by the following relation. [ 15 ]

A_{m} = 1 / ((), N_{A} normalΓ)

Here, A m is area occupied by single molecule and N A is Avogadro's number.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, in literature viscometric and volumetric study, determination of CMC and related parameters and drug–surfactant interaction are reported separately, but we have combined all these studies for a single drug in a single paper, like our other publications on other drugs. [ 5,14,15 ] In these publications, metformin hydrochloride (Met HCl), sodium valproate (SV), and chlorpheniramine maleate (CPAM) in aqueous medium were studied. All these drugs showed hydrophobic interaction with water solvent.…”

Section: Introductionmentioning

confidence: 99%

“…All these drugs showed hydrophobic interaction with water solvent. [ 5,14,15 ] Molecules of CPAM become incorporated between the ionic heads of micelles of sodium dodecyl sulfate (SDS) [ 15 ] while those of Met HCl and SV showed interaction with surfactant by attachment on the surface of micelles of SDS and cetyltrimethylammonium bromide (CTAB), [ 5,14 ] respectively. In the present study, a different drug, that is, LP was used, and its viscometric, volumetric studies, and interaction with CTAB were carried out.…”

Section: Introductionmentioning

confidence: 99%

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Study of volumetric, viscometric, and aggregation properties of losartan potassium and its interaction with amino acids and cetyltrimethylammonium bromide in aqueous solution

Shakeel

Mahmood

2020

J of Physical Organic Chem

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This manuscript reports volumetric, viscometric, and aggregation properties of losartan potassium (LP) in aqueous medium and its interaction with a cationic surfactant (cetyltrimethylammonium bromide [CTAB]). Densities of drug solutions were used to calculate apparent molar volumes while constants of Jones–Dole equation were calculated from viscosity measurements. By measuring surface tension, refractive index, and electrical conductivity of drug solutions, critical micelle concentration (CMC) of drug was determined, and calculation of surface excess concentration, free energy change of adsorption, free energy change, entropy change, and enthalpy change of micellization was carried out. UV/Visible spectroscopic data were used to get an understanding about the interaction of drug with cationic surfactant (CTAB). This interaction gives an idea about the interaction of drug with biomembrane as micelles of surfactant are similar to membranes in structure. The data were also used to calculate different important parameters for drug–surfactant interaction such as partition coefficient and binding constant. Moreover, two amino acids (glycine and l‐tryptophan) were used in solutions of drug separately to change its CMC. The results from volumetric and viscometric studies showed that the presence of drug in solution resulted in more organization of solvent molecules due to hydrophobic interaction. From the values of ∆G°ads and ∆G°m, it was concluded that the adsorption of drug molecules at solution–air interface and formation of micelles occurred spontaneously. A strong drug‐surfactant (LP–CTAB) interaction was observed by the attachment of drug molecules onto micellar surface of surfactant. The presence of amino acids in the solution of drug caused a decrease in the CMC of LP.

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“…The densities of drug solutions, measured at specified temperatures, were used to calculate apparent molar volume ( V ϕ ) with the help of Equation . [ 14,15 ]

V_{ϕ} = M_{2} / ρ + ((), ρ_{0} - ρ) / ((), ρ_{0} italicρm)

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The degree of packing of drug molecules at the surface is expressed by the minimum area its molecule occupies at air–solution interface and is calculated by the following relation. [ 15 ]