Volumenbestimmung von Pigmentepithelabhebungen bei AMD mittels Laser-Scanning-Tomographie

Abstract

Confocal laser scanning tomography allows analysis of 3D configurations and a quantitative measurement of RPE detachments in AMD. Therefore, this diagnostic technique appears to be useful, especially for differentiated follow-up examinations (as in therapy-control studies). Furthermore, the analysis of 3D configurations seems to be useful to estimate the risk of tearing of the RPE and may help to indicate underlying neovascularizations.

Pigment epithelial detachment in the elderly

“…They were initially medium sized, but area and volume of the PED enlarged with eventual regression. This resulted most often in a disciform scar, but as found in other studies [27] RPE tears sometimes developed. In general RPE tears most often developed in initial large PED and increased further in volume, resulting in sufficient tangential stress to rupture the RPE [8,9,24].…”

“…At the initial examination and follow-up examinations every 3 months the following investigations were performed: ETDRS visual acuity, ophthalmoscopic fundus examination and fluorescein and indocyanine green (ICG) angiography. The area of PED was analyzed on the ICG angiogram, and the PED volume was measured using the Heidelberg Retina Tomograph (HRT Heidelberg, Germany) using a method resulting in reproducible volume measurements as demonstrated in earlier studies [27]. The total number of eyes with visual loss in each PED group was recorded, and the cumulative risk was analyzed using KaplanMeier statistics.…”

Die Pigmentepithelabhebung bei der AMD

“…Groûe individuelle Unterschiede in der klinischen und angiographischen Charakterisierung der Pigmentepithelabhebungen sind beschrieben [4,12,16,17,24]. Diese scheinen genetisch prädisponiert zu sein [10,13,19,22] (p = 0,0044), Assoziation einer Neovaskularisation (p = 0,0004), Fläche (p < 0,001), Volumen (p = 0,0077) und Höhe (p < 0,0001) der Pigmentepithelabhebung.…”