Volume replacement with hydroxyethyl starch (HES) 130/0.4 and ringer lactate solution in pigs after severe haemorrhage: A small bowel mucosa preliminary study

Abstract

Clinical and Experimental Circulation for 12 hours. Incidence of hypotension (defined as a 30% reduction in Systolic BP from SBP thirty min af ter SA) was recorded and treated with 250 ml Ringer's lactate solution and bolus of ephedrine. We also assessed postoperative blood loss at H1, H3, H6 and H12. Continuous data were compared using Mann Whitney test and parametric data were analysed using Fisher exact test. Results and Discussion: Patient characteristics, heart rate, SBP were similar among groups. There were no significant dif ferences in mean SBP values between the two groups immediately af ter tourniquet release. Mean SBP were significantly lower in group G only at H6, H7, H8 and H9. The incidence of hypotension was significantly higher in group G (82% vs 47% ; p=0.03). But the dif ference between the two groups for blood loss and allogeneic blood transfusion was not statistically significant Conclusion(s): The primarily results of our study suggest that preloading with Voluven® (Hydroxyethyl Starch 130/0.4) before tourniquet release in patient undergoing TK A was associated with bet ter hemodynamic stability than Plas-mion® (4% Gelatin). The study is going one to confirm such results.