Volume Progression in Polycystic Kidney Disease

Grantham, Jared J.; Torres, Vicente E.; Chapman, Arlene B.; Guay‐Woodford, Lisa M.; Bae, Kyongtae T.; King, Bernard F.; Wetzel, Louis H.; Baumgarten, Deborah A.; Kenney, Philip J.; Harris, Peter C.; Klahr, Saulo; Bennett, William M.; Hirschman, Gladys N.; Meyers, Catherine M.; Xiao-ling, Zhang; Zhu, Fang; Miller, J. Philip

doi:10.1056/nejmoa054341

Cited by 690 publications

(727 citation statements)

References 26 publications

Supporting

Mentioning

660

Contrasting

Unclassified

Order By: Relevance

“…When noninvasive in vivo imaging is the only option, TKV is used as a biomarker which has been shown to correlate with ADPKD progression (9). However, measurement of TKV by manual tracing of 3D MR images has been shown to be challenging (26).…”

Section: Discussionmentioning

confidence: 99%

“…Imaging modalities such as ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) are used to monitor disease progression (8). Clinical studies utilize total kidney volume (TKV) measured by MRI as an image-based biomarker to follow the progression of ADPKD since larger TKVs have been shown to correlate with worse prognosis in ADPKD in both human (9), and murine studies (10). However, there are challenges with using TKV as a marker of disease progression.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Utilizing magnetization transfer imaging to investigate tissue remodeling in a murine model of autosomal dominant polycystic kidney disease

Kline

Irazabal

Ebrahimi

et al. 2015

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose Non-invasive imaging techniques that quantify renal tissue composition are needed to more accurately ascertain prognosis and monitor disease progression in polycystic kidney disease (PKD). Given the success of Magnetization Transfer (MT) imaging to characterize various tissue remodeling pathologies, it was tested on a murine model of autosomal dominant PKD. Methods C57Bl/6 Pkd1 R3277C mice at 9, 12, and 15-months were imaged with a 16.4T MR imaging system. Images were acquired without and with RF saturation in order to calculate MT ratio (MTR) maps. Following imaging, the mice were euthanized and kidney sections were analyzed for cystic and fibrotic indices which were compared to statistical parameters of the MTR maps. Results MTR derived mean, median, 25th percentile, skewness, and kurtosis were all closely related to indices of renal pathology such as kidney/body weight, cystic index, and percent of remaining parenchyma. The correlation between MTR and histology derived cystic and fibrotic changes was good at R2 = 0.84, and R2 = 0.70, respectively. Conclusion MT imaging provides a new, non-invasive means to measure tissue remodeling changes of PKD and may be better suited for characterizing renal impairment compared with conventional MR techniques.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utilizing magnetization transfer imaging to investigate tissue remodeling in a murine model of autosomal dominant polycystic kidney disease

Kline

Irazabal

Ebrahimi

et al. 2015

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Abnormality of the PKD1 gene is considered to contribute to a poor kidney prognosis in patients with kidney disease compared with PKD2 gene abnormality [13]. On the other hand, clinical outcome of patients with kidney disease is known to be variable even among members of the same family [14].…”

Section: Discussionmentioning

confidence: 99%

Two autosomal dominant polycystic kidney (ADPKD) cases with advanced renal dysfunction, effectively treated with tolvaptan

et al. 2015

View full text Add to dashboard Cite

We report here two cases of autosomal dominant polycystic kidney disease (ADPKD) with renal dysfunction that were treated with tolvaptan. Case 1 was a 47-year-old man with a glomerular filtration rate (GFR) of 17.0 ml/min/1.73 m 2 who received tolvaptan treatment (30 mg/day). After treatment, kidney pain was alleviated, and the estimated GFR (eGFR) decline improved from -9.84 ml/min/1.73 m 2 per year to -4.08 ml/min/1.73 m 2 per year, respectively. The rate of increase in total kidney volume was reduced from 18 % per year before treatment to 4 % per year following tolvaptan administration. Case 2 was a 44-year-old man with a GFR of 22.6 ml/min/ 1.73 m 2 , and the eGFR decline improved from -5.76 ml/ min/1.73 m 2 per year before treatment to -3.12 ml/min/ 1.73 m 2 per year following tolvaptan treatment (30 mg/day). The rate of increase in total kidney volume was also decreased from 10 % per year before treatment to -7 % per year following tolvaptan administration. These results suggested that tolvaptan may be effective in impeding kidney function aggravation and kidney volume increase in ADPKD patients with advanced renal dysfunction.

show abstract

“…Clinical trials for ADPKD therapies began after the NIH-sponsored Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) showed total kidney volume (TKV) correlates with disease progression, detects change in individuals with normal lab values, and can do so after as little as 12 months [10]. The current standard for TKV measurements in ADPKD studies and clinical trials is stereology [11]. The labeled stereology data consist of an undersampled grid of points overlaid on each image in an exam series, labeled by a trained user.…”

Section: Introductionmentioning

confidence: 99%

“…The method we developed aims to utilize labeled stereology grids, routinely obtained in ADPKD imaging studies like CRISP [11] and used to obtain the primary volume outcome metric in clinical trials [13][14][15], to segment volumes of interest. We hypothesize these stereology data will provide a rich source of a priori information to supervise and constrain soft tissue segmentations and will test this using magnetic resonance imaging (MRI) series from polycystic kidneys.…”

Section: Introductionmentioning

confidence: 99%

Supervised Segmentation of Polycystic Kidneys: a New Application for Stereology Data

et al. 2014

Self Cite

View full text Add to dashboard Cite

Stereology is a volume estimation method, typically applied to diagnostic imaging examinations in population studies where planimetry is too time-consuming (Chapman et al. Kidney Int 64:1035-1045, 2003, to obtain quantitative measurements (Nyengaard J Am Soc Nephrol 10: 1100-1123, Michel and Cruz-Orive J Microsc 150:117-136, 1988 of certain structures or organs. However, true segmentation is required in order to perform advanced analysis of the tissues. This paper describes a novel method for segmentation of region(s) of interest using stereology data as prior information. The result is an efficient segmentation method for structures that cannot be easily segmented using other methods.

show abstract

Volume Progression in Polycystic Kidney Disease

Abstract: Background Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of cyst-filled kidneys. Methods

Cited by 690 publications

References 26 publications

Utilizing magnetization transfer imaging to investigate tissue remodeling in a murine model of autosomal dominant polycystic kidney disease

Utilizing magnetization transfer imaging to investigate tissue remodeling in a murine model of autosomal dominant polycystic kidney disease

Two autosomal dominant polycystic kidney (ADPKD) cases with advanced renal dysfunction, effectively treated with tolvaptan

Supervised Segmentation of Polycystic Kidneys: a New Application for Stereology Data

Contact Info

Product

Resources

About