Volume of Lymphatic Metastases Does Not Independently Influence Prognosis in Colorectal Cancer

Wong, Jan H.; Steinemann, Susan; Tom, Paul; Morita, Shane Y.; Tauchi-Nishi, Pamela

doi:10.1200/jco.2002.20.6.1506

Cited by 19 publications

(7 citation statements)

References 24 publications

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“…In addition, the VCP level proved to be a prognosticator for recurrence of the disease in lymph node-positive patients (stage III) as well as node-negative patients (stage II): 5-year disease-free survival rate in patients with low and high VCP expression was 100 and 72.8% at stage II and 100 and 48.4% at stage III, respectively. Although lymph node metastasis is an indicator of poor prognosis of patients with colorectal carcinomas, heterogeneity of the prognosis among patients with positive lymph nodes has been a problem (20). The present study has clearly demonstrated the usefulness of VCP expression in predicting distant metastasis in node-positive patients.…”

Section: Discussionmentioning

confidence: 56%

Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis

Yamamoto¹,

Tomita

Hoshida

et al. 2004

Clinical Cancer Research

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Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-B signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in colorectal adenocarcinoma.Experimental Design: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35-84 years. The staining intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than that in noncancerous colonic mucosa. We also analyzed 8 colorectal adenomas and 10 metastatic foci.Results: Low VCP expression was noted in 41 (31.8%) cases and high expression in 88 (68.2%) cases. A low level of VCP expression was noted in all adenomas, whereas a high level was seen in all metastatic tumors. A significant difference was observed in depth of invasion (T 1-2 versus T 3-4 , P < 0.05), presence or absence of venous invasion (P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression. Patients with high VCP-expressing tumors had a higher recurrence rate (P < 0.001) and poorer disease-free and overall survival (P < 0.01 and P < 0.05, respectively) compared with the low expression group. Multivariate analysis revealed VCP expression level to be an independent prognosticator for both disease-free and overall survival. VCP level was an indicator of disease-free survival in both stage II and III (pathological Tumor-Node-Metastasis classification, P < 0.05 and <0.01, respectively). Conclusions: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas.

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Section: Discussionmentioning

confidence: 56%

Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis

Yamamoto¹,

Tomita

Hoshida

et al. 2004

Clinical Cancer Research

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“…Survival rates have been shown to decrease with increasing numbers of positive lymph nodes. Nodal metastasis is commonly small, and evidence suggests that patients with micrometastasis in multiple nodes by H&E examination may have an outcome similar to patients with multiple macrometastasis (22). Conversely, high numbers of negative lymph nodes have been correlated with better survival.…”

Section: Lymph Node Special Techniquesmentioning

confidence: 99%

Newer Pathologic Assessment Techniques for Colorectal Carcinoma

Turner

Compton

2007

Clinical Cancer Research

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“…We are aware of only one previous study assessing metastasis volume in CRCs [35]. In that study, total nodal volume was estimated on the basis of two-dimensional histological slides, and was found to be in weak correlation (correlation coefficient: r ¼ 0.45, P-value not reported) with the number of LNs involved.…”

Section: Discussionmentioning

confidence: 94%

The impact of the largest metastasis size on nodal tumor burden in colorectal carcinomas: implications for the sentinel lymph node theory in cancers of the large intestine

Vinh-Hung

Vajda

Svébis

2007

Journal of Surgical Oncology

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The correlation of the largest metastasis size with the number and the ratio of involved nodes may be an indirect proof of the sequential spread from first echelon LNs to further nodes. However, the data suggest a more complex process: with increasing metastasis size, the number of involved nodes and its variability increase more than might be expected. This suggests a recruitment or cascade process, which becomes more unpredictable as nodal tumor burden increases.

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Volume of Lymphatic Metastases Does Not Independently Influence Prognosis in Colorectal Cancer

Cited by 19 publications

References 24 publications

Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis

Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis

Newer Pathologic Assessment Techniques for Colorectal Carcinoma

The impact of the largest metastasis size on nodal tumor burden in colorectal carcinomas: implications for the sentinel lymph node theory in cancers of the large intestine

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