Volume of hippocampal subfields and episodic memory in childhood and adolescence

Lee, Joshua K.; Ekstrom, Arne D.; Ghetti, Simona

doi:10.1016/j.neuroimage.2014.03.019

Cited by 127 publications

(190 citation statements)

References 65 publications

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“…Despite impaired episodic memory, first noted at age 4, H.C. completed high school and 2 years of college, and has successfully held several jobs. She was most recently scanned at age 22 on a 3T MRI scanner with an established high-resolution MTL protocol for volumetric analysis of the MTL and hippocampal subregions (Olsen et al, 2013; see also Lee et al, 2014). Results indicated hippocampal volume reduction of 29.5% on the left and 31.2% on the right compared to controls, limited to the hippocampal formation and equally distributed across the subfields and the anterior-posterior axis, which is significantly lower than previous estimates of 48.1% on the left and 43.5% on the right based on averaged patient group volumes (Adlam et al, 2005).…”

Section: Participantsmentioning

confidence: 99%

Congenital absence of the mammillary bodies: A novel finding in a well-studied case of developmental amnesia

et al. 2014

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Section: Participantsmentioning

confidence: 99%

Congenital absence of the mammillary bodies: A novel finding in a well-studied case of developmental amnesia

et al. 2014

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“…We expected to replicate initial evidence for the relatively late maturation of the DG (14). In addition, we reasoned that individual differences in a multivariate index of HC maturity would predict individual differences in processes that support the specific encoding of unique events such as pattern separation.…”

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confidence: 91%

“…For example, the dentate gyrus (DG) has been closely linked to pattern separation (6). Developmental findings from animal models (13) and initial evidence from human studies (14) suggest that the DG matures later than other HC subfields. Likewise, memory functions associated with pattern separation, such as recollection (6), show a protracted course of development that extends well into middle childhood (15).…”

mentioning

confidence: 99%

“…Moreover, existing animal and human data suggest that all HC subfields undergo maturational changes during early development (13,14,20), albeit along different trajectories. Both of these observations call for a multivariate approach to investigate HC Significance Children tend to extract schematic knowledge at the expense of learning and recollecting specific events.…”

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confidence: 99%

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Hippocampal maturity promotes memory distinctiveness in childhood and adolescence

Keresztes

Bender

Bodammer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

118

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Adaptive learning systems need to meet two complementary and partially conflicting goals: detecting regularities in the world versus remembering specific events. The hippocampus (HC) keeps a fine balance between computations that extract commonalities of incoming information (i.e., pattern completion) and computations that enable encoding of highly similar events into unique representations (i.e., pattern separation). Histological evidence from young rhesus monkeys suggests that HC development is characterized by the differential development of intrahippocampal subfields and associated networks. However, due to challenges in the in vivo investigation of such developmental organization, the ontogenetic timing of HC subfield maturation remains controversial. Delineating its course is important, as it directly influences the fine balance between pattern separation and pattern completion operations and, thus, developmental changes in learning and memory. Here, we relate in vivo, high-resolution structural magnetic resonance imaging data of HC subfields to behavioral memory performance in children aged 6-14 y and in young adults. We identify a multivariate profile of age-related differences in intrahippocampal structures and show that HC maturity as captured by this pattern is associated with age differences in the differential encoding of unique memory representations.hippocampal subfields | episodic memory | specificity | pattern separation | child development M any years ago, the Swiss developmentalist Jean Piaget noted an imbalance between assimilation and accommodation during early and middle childhood in the sense that children tend to extract schematic knowledge at the expense of learning and recollecting specific events (1, 2). This imbalance has resurfaced in computational models of memory (3), and later as the imbalance between pattern completion and pattern separation, processes linked to computational properties of subfields within the hippocampus (HC) (4-6). Understanding the developmental organization of HC subfields is therefore crucial to understand how associated changes in HC-subfield computations drive concomitant changes in learning and memory.An important step toward unraveling controversies about human hippocampal maturation (7,8) is to acknowledge that the HC is not a homogeneous structure, but rather is composed of cytoarchitectonically and functionally distinct subfields (9). The availability of high-resolution, in vivo magnetic resonance imaging (MRI) of the HC permits the study of specific contributions of different HC subfields in humans (10-12). Computational and rodent models of HC function and high-resolution MRI studies in humans have sought to establish the contributions of individual HC subfields to specific mnemonic functions. For example, the dentate gyrus (DG) has been closely linked to pattern separation (6). Developmental findings from animal models (13) and initial evidence from human studies (14) suggest that the DG matures later than other HC subfields. Likewise, memory funct...

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“…This developmental patterns of spatial relational memory support the notion developed by Jabès and Nelson (2015), and following their suggestion may reflect a progressive development first of the CA1 field of the hippocampus followed by maturation the CA3 and dentate gyrus later on. Interestingly, significant increases in CA3/DG volumes were recently demonstrated in humans from childhood to early adolescence and these volumetric changes were positively correlated with memory performance (Lee, Ekstrom, & Ghetti, 2014). In light of these findings, it was not surprising to find that neonatal damage of the hippocampus did impact performance on both tasks and more importantly this impairment occurred at an age when these types of memory first emerged in the control monkeys, i.e.…”

Section: Maturation Of Relational Memory Processesmentioning

confidence: 99%

Commentary

Bachevalier

2015

International Journal of Behavioral Development

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Studies investigating the development of memory processes and their neural substrates have flourished over the last two decades. The review by Jabès and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development of hippocampal-dependent memory processes in humans. In this accompanying commentary, we explore some additional connections between the nonhuman primate work and the human data, and take the opportunity to highlight some common and additional interpretations of the results. This commentary makes three points: (1) the recognition processes present in the first few days of life may be linked to the early maturation of the medial temporal cortical areas instead of, or in addition to, the early maturation of the subiculum; (2) recent findings on the differential protracted maturation of spatial relational memory processes in monkeys further support the notion proposed by Jabès and Nelson that this protracted development may reflect progressive maturation of the CA1 field of the hippocampus followed by further maturation of CA3/dentate gyrus; (3) finally, further considerations of the differential maturation of the longitudinal hippocampal axis and of the diencephalon are proposed as additional contributors to the refinement of episodic memory functions during development.

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Volume of hippocampal subfields and episodic memory in childhood and adolescence

Cited by 127 publications

References 65 publications

Congenital absence of the mammillary bodies: A novel finding in a well-studied case of developmental amnesia

Congenital absence of the mammillary bodies: A novel finding in a well-studied case of developmental amnesia

Hippocampal maturity promotes memory distinctiveness in childhood and adolescence

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