2019
DOI: 10.1016/j.radonc.2018.12.018
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Volume not number of metastases: Gamma Knife radiosurgery management of intracranial lesions from an Australian perspective

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Cited by 14 publications
(17 citation statements)
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“…Specifically, patients with volumes <3.2 cm 3 experienced a median survival time of 11.4 months, while median survival time decreased to 5.2 months for patients with volumes >9.1 cm 3 . Multivariable Cox proportional regression analysis identified total tumor volume (HR: 1.21, 95% CI: 1.09‐1.34, P < .01) as significant predictors of survival outcomes . In our study, we suppose that total BM tumor volume might not be significantly associated with OS in multivariate analysis, because the inclusion criteria of this study were limited to the patients with limited number (1‐4) of BM tumor and radiologic follow‐up of more than 3 months.…”
Section: Discussionmentioning
confidence: 84%
“…Specifically, patients with volumes <3.2 cm 3 experienced a median survival time of 11.4 months, while median survival time decreased to 5.2 months for patients with volumes >9.1 cm 3 . Multivariable Cox proportional regression analysis identified total tumor volume (HR: 1.21, 95% CI: 1.09‐1.34, P < .01) as significant predictors of survival outcomes . In our study, we suppose that total BM tumor volume might not be significantly associated with OS in multivariate analysis, because the inclusion criteria of this study were limited to the patients with limited number (1‐4) of BM tumor and radiologic follow‐up of more than 3 months.…”
Section: Discussionmentioning
confidence: 84%
“…A total of eight Australian studies were identified and included in this review (Table ) – one prospective randomized controlled trial (RCT) that was terminated before its accrual target was met, and seven retrospective single‐institutional studies from South Australia, Victoria, Queensland and New South Wales, respectively. The RCT randomized patients with solitary BM to either surgery plus WBRT or SRS plus WBRT – only results from the SRS plus WBRT arm were included in this review.…”
Section: Resultsmentioning
confidence: 99%
“…also reported on mutation status for lung cancer (26% EGFR/ALK mutant and 74% EGFR/ALK wild‐type) and histological subtypes of breast cancer (41% Her2+ve and 59% Her2−ve). Five studies reported on the extracranial extent of cancer, with large majority of patients in most studies reported to have extracranial disease, except the study by Izard et al . whereby only about one‐third of patients had extracranial disease.…”
Section: Resultsmentioning
confidence: 99%
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