Volume load‐induced right ventricular dysfunction in animal models: insights in a translational gap in congenital heart disease

Bossers, Guido P L; Hagdorn, Quint A.J.; Ploegstra, Mark‐Jan; Borgdorff, M. A. J.; Silljé, Herman H W; Berger, Rolf M. F.; Bartelds, Beatrijs

doi:10.1002/ejhf.931

Cited by 23 publications

(32 citation statements)

References 43 publications

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“…Zebrafish embryos are excellent for non-invasive live imaging, but their small size and clutch numbers make systematic proteomic analysis difficult. The data and conclusions obtained from different animal models can be mutually confirmed and complement each other, and jointly construct a panoramic view of understanding of heart development and cardiovascular diseases ( Afouda and Hoppler, 2009 ; Bossers et al, 2018 ).…”

Section: Heart Development Is Highly Conserved Across Speciesmentioning

confidence: 69%

“…Zebrafish possess highly efficient cardiac regenerative capacity throughout their lifetime, providing novel insights into the understanding of human cardiac regeneration ( Bournele and Beis, 2016 ; Bossers et al, 2018 ). The zebrafish heart can reform a fully functional heart even after substantial damages ( Sehring et al, 2016 ; Tahara et al, 2016 ; González-Rosa et al, 2018 ).…”

Section: Heart Regeneration In Non-mammalian Organisms and Applicatiomentioning

confidence: 99%

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Heart Development and Regeneration in Non-mammalian Model Organisms

Xia

Meng

Ruan

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant advance in the field of therapeutic heart regeneration. Most of our understanding of heart development and regeneration, including the genes and signaling pathways, are driven by pioneering works in non-mammalian model organisms, such as fruit fly, fish, frog, and chicken. Compared to mammalian animal models, non-mammalian model organisms have special advantages in high-throughput applications such as disease modeling, drug discovery, and cardiotoxicity screening. Genetically engineered animals of cardiovascular diseases provide valuable tools to investigate the molecular and cellular mechanisms of pathogenesis and to evaluate therapeutic strategies. A large number of congenital heart diseases (CHDs) non-mammalian models have been established and tested for the genes and signaling pathways involved in the diseases. Here, we reviewed the mechanisms of heart development and regeneration revealed by these models, highlighting the advantages of non-mammalian models as tools for cardiac research. The knowledge from these animal models will facilitate therapeutic discoveries and ultimately serve to accelerate translational medicine.

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Section: Heart Development Is Highly Conserved Across Speciesmentioning

confidence: 69%

Section: Heart Regeneration In Non-mammalian Organisms and Applicatiomentioning

confidence: 99%

Heart Development and Regeneration in Non-mammalian Model Organisms

Xia

Meng

Ruan

et al. 2020

Front. Cell Dev. Biol.

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“…Chronic PR results in abnormal increase in RV preload and afterload, and over time leads to irreversible RV dysfunction and cardiovascular morbidities. [3][4][5] The current study showed that echocardiographic indices of RV-PA coupling were comparable to CMRI-derived RV…”

Section: Discussionmentioning

confidence: 82%

“…Chronic pulmonary regurgitation (PR), which is one of the most common reasons for reintervention in adults with congenital heart disease, particularly in patients with tetralogy of Fallot (TOF) and valvular pulmonic stenosis (VPS) with prior right ventricular (RV) outflow tract interventions . Chronic PR causes RV volume overload resulting in increased RV preload, as well as volume overload of the proximal central pulmonary artery (PA) and vascular remodeling ultimately resulting in increased RV afterload . The goal of pulmonary valve replacement is to prevent progressive RV dysfunction by normalizing these abnormal loading conditions .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Chronic PR causes RV volume overload resulting in increased RV preload, as well as volume overload of the proximal central pulmonary artery (PA) and vascular remodeling ultimately resulting in increased RV afterload. [3][4][5] The goal of pulmonary valve replacement is to prevent progressive RV dysfunction by normalizing these abnormal loading conditions. 6 The timing of pulmonary valve replacement is critical in order to avoid the cumulative multiple reinterventions that can occur if pulmonary valve replacement is performed too early or the irreversible RV dysfunction that can result if pulmonary valve replacement is performed too late.…”

Section: Introductionmentioning

confidence: 99%

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Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation

Egbe

Miranda

Pellikka

et al. 2019

Congenital Heart Disease

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Background We hypothesized that echocardiographic indices of right ventricular to pulmonary artery (RV‐PA) coupling were comparable to cardiac magnetic resonance imaging (CMRI)‐derived RV volumetric indices in predicting disease severity in chronic pulmonary regurgitation (PR). Methods Patients with ≥ moderate PR (2003‐2015) with and without prior CMRI scans were enrolled into the study cohort and validation cohort, respectively. Endpoint was to determine the association between noninvasive RV‐PA coupling indices (tricuspid annular plane systolic excursion/right ventricular systolic pressure [TAPSE/RVSP] and fractional area change [FAC]/RVSP ratio) and markers of disease severity, and compared this association to that of CMRI‐derived RV volumetric indices and markers of disease severity (peak oxygen consumption [VO2], NT‐proBNP and atrial and/or ventricular arrhythmias). Results Of the 256 patients in the study cohort (age 33 ± 6 years), 187 (73%) had tetralogy of Fallot (TOF) while 69 (27%) had valvular pulmonic stenosis (VPS). TAPSE/RVSP (r = 0.73, P < .001) and FAC/RVSP (r = 0.78, P < .001) correlated with peak VO2. Among the CMRI‐derived RV volumetric indices analyzed, only right ventricular end‐systolic volume index correlated with peak VO2 (r = −0.54, P < .001) and NT‐proBNP (r = 0.51, P < .001). These RV‐PA coupling indices were tested in the validation cohort of 218 patients (age 37 ± 9 years). Similar to the study cohort, TAPSE/RVSP (r = 0.59, P < .001) and FAC/RVSP (r = 0.70, P < .001) correlated with peak VO2. TAPSE/RVSP (but not FAC/RVSP) was also associated with arrhythmia occurrence in both the study cohort and validation cohorts. Conclusion Noninvasive RV‐PA coupling may provide complementary prognostic data in the management of chronic PR. Further studies are required to explore this clinical tool.

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Volume Overload and the Right Heart

Sanz

2021

The Right Heart

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Volume load‐induced right ventricular dysfunction in animal models: insights in a translational gap in congenital heart disease

Cited by 23 publications

References 43 publications

Heart Development and Regeneration in Non-mammalian Model Organisms

Heart Development and Regeneration in Non-mammalian Model Organisms

Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation

Volume Overload and the Right Heart

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