Volume Elasticity Characteristics of the Human Aorta and Prediction of the Stroke Volume From the Pressure Pulse

Remington, J. W.; Noback, Charles R.; Hamilton, W. F.; Gold, Jay J.

doi:10.1152/ajplegacy.1948.153.2.298

Cited by 92 publications

(26 citation statements)

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“…Hg in the aorta indicating a stroke index of about 35 cc. according to the calculations of Remington et al (12). The circulation index is therefore approximately 3.5 L, a higher figure than was given by the dye injection method when the patient was not cyanotic.…”

mentioning

confidence: 71%

Notes on a Case of Congenital Heart Disease With Cyanotic Episodes 12

Winslow¹,

Hamilton²

1950

J. Clin. Invest.

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confidence: 71%

Notes on a Case of Congenital Heart Disease With Cyanotic Episodes 12

Winslow¹,

Hamilton²

1950

J. Clin. Invest.

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“…However, most of the variability in published results appears to be real and is attributable to differences in aortic compliance between different subjects. Variability of aortic compliance in man is well known and indeed has thwarted attempts to measure stroke volume from the pressure pulse (Remington et al, 1948).…”

Section: Discussionmentioning

confidence: 99%

Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree.

O’Rourke¹,

Avolio²

1980

Circulation Research

130

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SUMMARY This study seeks to explain mechanisms responsible for the contour of pressure and flow waves and the pattern of vascular impedance in human systemic arteries. Pulsatile pressure and flow were recorded from the ascending aorta of seven patients undergoing open heart surgery and from the ascending aorta and other arteries of 17 patients at diagnostic catheterization. Ascending aortic pressure/flow relationships in the seven surgical patients were expressed as input impedance to the systemic circulation. Pressure and flow wave contour and impedance results were interpreted with the aid of a multibranched model of the systemic arterial tree, whose parameters could be manipulated to simulate different physiological and pathological conditions. Our data and data previously published on pressure and flow waves and their relationship in human subjects could be explained on the basis of two reflecting sites in the systemic circulation-one representing the resultant of all arterial terminations in the upper part of the body, and the other, some 1.5 times further away, the resultant of all arterial terminations in the lower body. The concept of the arterial system as an asymmetric T tube with two discrete ends has been advanced previously to explain the main features of pressure and flow waves and their relationship in different experimental animals. This concept appears equally applicable to human subjects.

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“…Although, PP/SI provides a theoretical estimate of the arterial Windkessel function, 30 the arterial system is not a closed circuit and the PP/SI has not been clinically validated as an estimate of arterial stiffness. Nonetheless, assessing the heart-arterial interaction by use of PP/SI and its utility as an approximate index of systemic arterial compliance has been well documented.…”

Section: Discussionmentioning

confidence: 99%

Contrasting Hemodynamic Mechanisms of Losartan- vs. Atenolol-Based Antihypertensive Treatment: A LIFE Study

et al. 2012

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Background pharmaceutical differences in central hemodynamics might influence cardiac response to antihypertensive treatment despite similar lowering of brachial blood pressure (Bp). MethodsData from all patients with at least two echocardiographic examinations in the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) echocardiographic substudy (n = 801); high-risk patients on losartan-vs. atenolol-based antihypertensive therapy. Echocardiography was performed annually for 4 years to measure stroke index (sI), heart rate, cardiac index (CI), conduit artery stiffness assessed as pulse pressure/stroke index (pp/sI) and total peripheral resistance index (tpRI).results Atenolol-and losartan-based therapy reduced Bp similarly (cumulative difference in mean brachial blood pressure 0.3 mm Hg, P = 0.65). After 4 years the cumulative means of sI and heart rate were 1.8 ml/m 2 higher and 5.7 beats/min lower on atenolol-based treatment, respectively (both P < 0.001). this kept CI below baseline in atenolol-treated patients, whereas in the losartan group CI was unchanged from baseline throughout the study. tpRI was decreased more and remained lower in the losartan group (cumulative difference in mean tpRI 287 dynes/sec −5 /cm/m 2 , P < 0.001). these findings partly explained univariate differences in systolic-and diastolic function indices between the two treatments; fully adjusted losartan was only associated with a smaller left atrial diameter (cumulative mean difference 0.07 cm; 95% confidence intervals, −0.13 to −0.01, P = 0.03).conclusions Contrasting hemodynamics impacted cardiac response to similar reductions in brachial Bp on losartan-vs. atenolol-based therapy. the similar reduction of pp/sI suggests that the antihypertensive regimens used in the LIFE study had comparable effects on arterial stiffness (LIFE study; NCt00338260)

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Volume Elasticity Characteristics of the Human Aorta and Prediction of the Stroke Volume From the Pressure Pulse

Cited by 92 publications

References 0 publications

Notes on a Case of Congenital Heart Disease With Cyanotic Episodes 12

Notes on a Case of Congenital Heart Disease With Cyanotic Episodes 12

Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree.

Contrasting Hemodynamic Mechanisms of Losartan- vs. Atenolol-Based Antihypertensive Treatment: A LIFE Study

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