Volume-corrected mitotic index as a prognostic factor in oral squamous cell carcinomas

Imai, Yasuo; Sasaki, Taro; Fujibayashi, Takashi

doi:10.1016/s1368-8375(00)00061-0

Cited by 12 publications

(14 citation statements)

References 11 publications

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“…Proliferative capacity of the cancers was evaluated using a well established method and represented as the volume corrected mitotic index (VCMI) [18]. This was also performed by 2 independent observers (MMA and AMZ) and the inter-observer variability was <3%.…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

et al. 2010

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BackgroundMitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs in different periampullary cancers. Therefore, we studied the expression profile of MMCs I, III, IV and V in periampullary cancers, reactive pancreatitis, normal pancreas and chronic pancreatitis.MethodsThis was a retrospective study on tissue microarrays constructed from formalin-fixed paraffin-embedded tissue from 126 consecutive patients (cancer = 104, chronic pancreatitis = 22) undergoing pancreatic resections between June 2001 and June 2006. 78 specimens of chronic pancreatitis tissue were obtained adjacent to areas of cancer. Normal pancreatic tissue was obtained from the resection specimens in a total of 30 patients. Metastatic tumours in 61 regional lymph nodes from 61 patients were also studied.ResultsMMCs I, III, IV and V were highly expressed (p < 0.05) in all primary periampullary cancers compared with metastatic lymph nodes and adjacent benign pancreas. MMCs III, IV and V were highly expressed in all cancers regardless of type compared with chronic pancreatitis (p < 0.05). Higher expression of MMCs I and V was associated with better survival and may, in part, relate to lower expression of these MMCs in poorly differentiated tumours compared with well and moderately differentiated tumours.ConclusionsDifferential expression of MMCs III, IV and V in primary periampullary cancers compared with adjacent benign periampullary tissue and chronic pancreatitis is a novel finding, which may render them attractive anticancer targets.

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Section: Methodsmentioning

confidence: 99%

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

et al. 2010

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“…25 Also volume corrected mitotic index (mitotic figures per square mm of neoplastic tissue in the microscopic field) is considered as the best predictor of prognosis. 26 The mitotic cells were numerous in basal and parabasal cell layers along with suprabasal layers in oral epithelial dysplasia whereas mitotic figures were distributed all throughout the superficial epithelium as well as nests, cords and sheets of infiltrating epithelial cells in squamous cell carcinoma. Also, in neoplastic tissues, the number of prophases is greatly reduced relative to metaphase stage which is of considerably longer duration.…”

Section: Discussionmentioning

confidence: 91%

Image analysis assisted study of mitotic figures in oral epithelial dysplasia and squamous cell carcinoma using differential stains

Tandon¹,

Singh

Brave

et al. 2016

Journal of Oral Biology and Craniofacial Research

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“…GPs are being used frequently for diagnostic and prognostic purposes in squamous cell carcinoma [11].…”

Section: Discussionmentioning

confidence: 99%

“…GPs are frequently used as diagnostic and prognostic markers of squamous cell carcinoma [11]. Elevated levels of glycosidases may occur in fibroblasts that are transformed by oncogenic viruses [12].…”

Section: Introductionmentioning

confidence: 99%

Impact of naringenin on glycoprotein levels in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats

et al. 2008

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We have studied the chemopreventive role of naringenin against experimental gastric carcinogenesis in male Wistar rats. The animals were divided into five groups and six animals were included in each group. Stomach, liver, sera and kidney specimens were collected in the 20th week and the level of glycoproteins namely, hexose, hexosamine, sialic acid and fucose, were measured in the control, gastric cancer-induced, cancer naringenin pretreated, cancer naringenin posttreated and naringenin alone animals. The glycoprotein levels were increased in the gastric cancer-induced rats when compared with the control rats. The levels of glycoprotein were decreased significantly in cancer-bearing rats supplemented with naringenin as compared with the gastric cancer-induced rats. The result shows the gastroprotective effect of naringenin and describes the likelihood of naringenin in maintaining the integrity of cell membranes and gastric mucosa against oxidative damage. Moreover, we hypothesize that regulation of glycoprotein levels by naringenin could be associated with the regression of N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinoma.

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Volume-corrected mitotic index as a prognostic factor in oral squamous cell carcinomas

Cited by 12 publications

References 11 publications

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

Image analysis assisted study of mitotic figures in oral epithelial dysplasia and squamous cell carcinoma using differential stains

Impact of naringenin on glycoprotein levels in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats

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