Volume‐controlled ventilation with superimposed high frequency ventilation during expiration in healthy and surfactant‐depleted pig lungs

Lachmann, Burkhard; Schairer, W.; Hafner, Mathias; Armbruster, S.; Jonson, B.

doi:10.1111/j.1399-6576.1989.tb03015.x

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…With the same level of mean Paw (during CHFVO) or the same CPAP level (during CHFV) as during CPPV, there was no further improvement in oxygenation resulting from HF waves. This confirms earlier findings on CHFV (12). However, it must be pointed out that the mode of CHFV differed from that used here ( 12).…”

Section: Cppvsupporting

confidence: 90%

“…This confirms earlier findings on CHFV (12). However, it must be pointed out that the mode of CHFV differed from that used here ( 12). When compared to both CHFV and CPPV, oxygenation during CHFVO in the present study was acquired with a lower peak Paw.…”

Section: Cppvsupporting

confidence: 88%

“…CHFV CHFVO HR beatlmin 94f 12 89f 10 97f11 cation of CPAP, and the effect was also quickly lost after the removal of CPAP (1 1). Enhanced CO, elimination with CHFV, as compared to CPPV, has been reported (5,12). However, in the present study, no difference in CO, washout was seen between CHFV and CPPV due to the protocol; nor were there any significant differences in CO,-washout between either CHFVO and CPPV or CHFVO and CHFV.…”

Section: Cppvcontrasting

confidence: 69%

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The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

Jousela

Måkelãinen

Linko

1992

Acta Anaesthesiol Scand

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Combined high frequency ventilation (CHFV) with 8 mmHg (1.0 kPa) continuous positive airway pressure (CPAP) and without CPAP (CHFV0) were compared to each other, and to continuous positive pressure ventilation (CPPV) with 8 mmHg (1.0 kPa) CPAP in pigs with oleic acid induced lung injury. The respiratory rate was 15 min-1 and the high frequency (HF) rate 360 min-1. Arterial carbon dioxide tension (PaCO2) was adjusted to 5 kPa and 25% oxygen was used. After CHFV, CPAP was briefly discontinued to allow the establishment of CHFV0 in order to examine the cardiovascular and pulmonary effects of combined high frequency ventilation alone. Mean arterial oxygen tension (PaO2) was 15.8 +/- 3.9 kPa during CPPV, 15.5 + 3.2 kPa during CHFV and 13.2 +/- 5.1 kPa during CHFV0 (ns). The peak airway pressure and the pericardiac pressure were lowest during CHFV0. CHFV provoked significant cardiovascular depression (mean arterial pressure, stroke index, left and right ventricle stroke work index). When compared to CPPV, a non-significant trend towards improved cardiovascular function was found during CHFV0. With similar mean airway pressures (during CHFV0) or the same CPAP (during CHFV) as during CPPV, no further improvement in oxygenation due to HF waves was found. Airway pressure was the major factor causing alterations in cardiovascular function, not the ventilation technique.

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Section: Cppvsupporting

confidence: 90%

Section: Cppvsupporting

confidence: 88%

Section: Cppvcontrasting

confidence: 69%

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The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

Jousela

Måkelãinen

Linko

1992

Acta Anaesthesiol Scand

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“…Lavage with normal saline has been used in different species to induce lung impairment by surfactant depletion (4,23,Sjostrand,personal communication). This study has shown that in dogs it is also a suitable method for establishing a moderate lung injury.…”

Section: Effects Of Lung Lavagementioning

confidence: 99%

Pulmonary effects of body position, PEEP, and surfactant depletion in dogs

Larsson¹,

Gilbert²,

Bunegin³

et al. 1992

Acta Anaesthesiol Scand

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The influence of position (sphinx, lateral, supine), surfactant depletion, and different positive end-expiratory pressure (PEEP) on functional residual capacity (FRC), series dead space (VdS) and compliance of the respiratory system (Crs) were evaluated in five dogs. Ventilation homogeneity as measured by an index (multiple breath alveolar mixing efficiency), oxygenation, and cardiovascular hemodynamics were additionally examined. The dogs were anesthetized with halothane, paralyzed, and mechanically ventilated. FRC and VdS were found to be notably large in dogs, 45 +/- 8 ml/kg and 6 +/- 1 ml/kg, respectively. FRC and ventilation homogeneity were improved in the sphinx position (prone position with upright head). Surfactant depletion by lung lavage with 37 degrees C saline caused an immediate and stable decrease in FRC, Crs, and oxygenation (P less than 0.05, respectively) for about 5 h without marked effects on the circulatory system. FRC and VdS increased with increasing PEEP. At the highest PEEP, 10 cmH2O (1 kPa), Crs decreased (P less than 0.05) and ventilation became more uneven, indicating alveolar overdistension.

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“…Protective ventilation was achieved in animal experiments. [33][34][35] However, we saw conceptual problems with extremely high respiratory frequencies combined with corresponding difficulties in monitoring and tuning ventilation to the need of the patient, which would not fit in clinical routine.…”

Section: Lung Mechanics Calculator 940mentioning

confidence: 99%

Pioneers in Mechanical Ventilation: Björn Jonson

Daoud

2022

JMV

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In this article, we highlight one of the pioneers of mechanical ventilation. Dr Björn Jonson is a physiologist, physician and currently a Professor Emeritus at Lund University in Sweden. He has spent the last sixty years of his life dedicated to research and inventions in the fields of respiratory failure and mechanical ventilation. With several devices invented, more than fifteen patents, more than 200 published articles and concepts, Dr. Jonson’s work has changed and revolutionized the way we understand the science of respiratory failure, and the way we practice and monitor mechanical ventilation today. More importantly, are the countless lives of patients saved all over the world because of his contribution. Keywords: Flow regulators, Servo Ventilator, Capnography

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Volume‐controlled ventilation with superimposed high frequency ventilation during expiration in healthy and surfactant‐depleted pig lungs

Cited by 7 publications

References 3 publications

The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

Pulmonary effects of body position, PEEP, and surfactant depletion in dogs

Pioneers in Mechanical Ventilation: Björn Jonson

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