Volume Changes of Corpus Striatum, Thalamus, Hippocampus and Lateral Ventricles in Posttraumatic Stress Disorder (PTSD) Patients Suffering from Headaches and without Therapy

Filipović, Branislav; Djurovic, B.M.; Marinković, Slobodan; Stijak, Lazar; Aksić, Milan; Nikolic, V.T.; Starčević, Ana; Radonjić, Vidosava

doi:10.1055/s-0030-1253349

Cited by 31 publications

(23 citation statements)

References 24 publications

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“…First, we detected a positive association of the rGMD of the putamen with dispositional optimism. This fits well with the findings showing diminished putamen GM structure in low optimism-related psychiatric disorders, such as major depression disorder, anxiety disorder, and posttraumatic stress disorder (Bora, Harrison, Davey, Yücel, & Pantelis, 2012;Filipovic et al, 2011;Lu et al, 2016;Parashos, Tupler, Blitchington, & Krishnan, 1998;Yoo et al, 2005). This finding is also in line with a diffusion tensor imaging study with a healthy population reporting an association of optimism with WM connectivity (i.e., the number of WM fiber tracts) between the putamen and frontal regions (Moutsiana, Charpentier, Garrett, Cohen, & Sharot, 2015).…”

Section: Discussionsupporting

confidence: 91%

Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence

Lai

Wang

Zhao

et al. 2019

Human Brain Mapping

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Dispositional optimism reflects one's generalized positive expectancies for future outcomes and plays a crucial role in personal developmental outcomes and health (e.g., counteracting related mental disorders such as depression and anxiety). Increasing evidence has suggested that extraversion is an important personality factor contributing to dispositional optimism. However, less is known about the association between dispositional optimism and brain structure and the role of extraversion in this association. Here, we examined these issues in 231 healthy high school students aged 16 to 20 years (110 males, mean age = 18.48 years, SD = 0.54) by estimating regional gray matter density (rGMD) using a voxel‐based morphometry method via structural magnetic resonance imaging. Whole‐brain regression analyses revealed a significant positive correlation between dispositional optimism and the rGMD of the bilateral putamen after adjusting for age, sex, family socioeconomic status (SES), general intelligence, and total gray matter volume (TGMV). Moreover, prediction analyses using fourfold balanced cross‐validation combined with linear regression confirmed a significant connection between dispositional optimism and putamen density after adjusting for age, sex, and family SES. More importantly, subsequent mediation analysis showed that extraversion may account for the association between putamen density and dispositional optimism after adjusting for age, sex, family SES, general intelligence, TGMV, and the other four Big Five personality traits. Taken together, the current study provides new evidence regarding the neurostructural basis underlying dispositional optimism in adolescents and underscores the importance of extraversion as an essential personality factor for dispositional optimism acquisition.

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Section: Discussionsupporting

confidence: 91%

Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence

Lai

Wang

Zhao

et al. 2019

Human Brain Mapping

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“…There are reports about an affection of the caudate and putamen in relation to early life traumas [56] and PTSD, [57], but in general, these structures have received relatively minor interest in the context of stress. The present finding of reduced structural volumes in the caudate and putamen, therefore, deserves particular consideration.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes

et al. 2013

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There are increasing reports of cognitive and psychological declines related to occupational stress in subjects without psychiatric premorbidity or major life trauma. The underlying neurobiology is unknown, and many question the notion that the described disabilities represent a medical condition. Using PET we recently found that persons suffering from chronic occupational stress had limbic reductions in the 5-HT1A receptor binding potential. Here we examine whether chronic work-related stress is also associated with changes in brain structure. We performed MRI-based voxel-based morphometry and structural volumetry in stressed subjects and unstressed controls focusing on gray (GM) and white matter (WM) volumes, and the volumes of hippocampus, caudate, and putamen – structures known to be susceptible to neurotoxic changes. Stressed subjects exhibited significant reductions in the GM volumes of the anterior cingulate cortex and the dorsolateral prefrontal cortex. Furthermore, their caudate and putamen volumes were reduced, and the volumes correlated inversely to the degree of perceived stress. Our results add to previous data on chronic psychosocial stress, and indicate a morphological involvement of the frontostriatal circuits. The present findings of morphological changes in these regions confirm our previous conclusion that symptoms from occupational stress merit careful investigations and targeted treatment.

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“…Thus, verbal memory impairments are the most consistent finding in PTSD, particularly autobiographical memory [55]. Other studies have seen other structural changes with PTSD in the corpus callosum [51, 56], premotor cortex [57], and areas of the prefrontal cortex [54, 58, 59]. Notably, these are areas often affecting brain responses to food cues and influencing feeding behaviors.…”

mentioning

confidence: 98%

Stress- and PTSD-associated obesity and metabolic dysfunction: A growing problem requiring further research and novel treatments

et al. 2014

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Posttraumatic stress disorder (PTSD) is a growing public health concern. More recently, evidence has indicated that PTSD leads to obesity and associated metabolic dysfunction. Possible mechanisms of this link are through dysfunction of the hypothalamic-pituitary-adrenal axis and related moderation of appetite hormones and neural activity, leading to changes in consumptive behaviors. Although research has been examining associations between PTSD and obesity, diabetes, cardiovascular disease, and metabolic syndrome, future research should delineate potential mechanisms for these associations and develop targeted treatments to reduce these metabolic outcomes.

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Volume Changes of Corpus Striatum, Thalamus, Hippocampus and Lateral Ventricles in Posttraumatic Stress Disorder (PTSD) Patients Suffering from Headaches and without Therapy

Cited by 31 publications

References 24 publications

Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence

Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence

Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes

Stress- and PTSD-associated obesity and metabolic dysfunction: A growing problem requiring further research and novel treatments

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