Volume Changes After Stereotactic LINAC Radiotherapy in Vestibular Schwannoma: Control Rate and Growth Patterns

Langenberg, R; Dohmen, Amy J. C.; Bondt, Bert J. de; Nelemans, Patty J.; Baumert, Brigitta G.; Stokroos, Robert J.

doi:10.1016/j.ijrobp.2011.12.023

Cited by 44 publications

(39 citation statements)

References 45 publications

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“…Patients in which the tumor volumes enlarged by two-fold or less and peaked within 2 years accounted for 93.2% of all patients in this study, demonstrating that our initial hypothesis was largely correct. Langenberg et al [33] used a 3D method similar to ours to measure and examine changes in tumor volumes and reported a 54% incidence of the transient growth pattern, which was very similar to our rate of 54.5%. Furthermore, two patients in whom the authors reported transient enlargement exhibited maximum tumor volumes of approximately 2.5-fold greater than the size at treatment (in both patients, the peak occurred within 2 years).…”

Section: Tumor Volume Change Patterns and Peaks In Transient Tumor Vosupporting

confidence: 83%

“…The incidence of this transient growth pattern has been reported to range from 3% to 80% [5,8,9,16,25,[29][30][31][32][33][34], and one reason for this disparity is thought to be the method for evaluating enlargement. It is necessary to determine whether tumors that enlarge early after treatment will continue to grow or instead begin to shrink.…”

Section: Tumor Volume Change Patterns and Peaks In Transient Tumor Vomentioning

confidence: 99%

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Long-term follow-up results of linear accelerator-based radiosurgery for vestibular schwannoma using serial three-dimensional spoiled gradient-echo MRI

Matsuo

Okunaga

Kamada

et al. 2015

Journal of Clinical Neuroscience

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Section: Tumor Volume Change Patterns and Peaks In Transient Tumor Vosupporting

confidence: 83%

Section: Tumor Volume Change Patterns and Peaks In Transient Tumor Vomentioning

confidence: 99%

Long-term follow-up results of linear accelerator-based radiosurgery for vestibular schwannoma using serial three-dimensional spoiled gradient-echo MRI

Matsuo

Okunaga

Kamada

et al. 2015

Journal of Clinical Neuroscience

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“…Varughese et al [22] have prospectively observed conservatively managed vestibular schwannomas using a three growth model and found that a volume-doubling model was the most realistic model in predicting tumour growth. Other studies have used magnetic resonance based volume calculations similar to our study [11,13,23]. They all show a promising future for the use of volumetric assessments to measure tumour growth and can significantly impact on clinical management of vestibular schwannomas from surveillance times to resection volumes when planning surgery.…”

Section: Discussionmentioning

confidence: 67%

Tumour Resection Volumes and Facial Nerve Outcomes for Vestibular Schwannomas

Virk

Tripathi

Randhawa

et al. 2014

Indian J Otolaryngol Head Neck Surg

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The objective of this study is to correlate tumour volume relationship with surgical outcomes in subtotal resections and accepted nomenclature through a retrospective study at Charing Cross Hospital, London, a tertiary referral centre. The participants were 16 patients with vestibular schwannoma managed with subtotal resection between 2002 and 2011. The main outcome measures were surgical technique; tumour volume; recurrence and post-operative facial nerve function. Mean preoperative and post-operative volumes for all patients were 14.7 and 3.7 cm 3 respectively. Tumour volumes do not correlate with diameter (p \ 0.05). Mean reduction in volume of these subtotal resections was 75 %. Long term facial nerve outcome was good in the majority of patients: House-Brackmann Grade I/II in 12 (75 %), Grade III/IV in 2 (12.5 %) and Grade V/VI in 2 patients (12.5 %). Notably, two patients with Grade I/II House-Brackmann grading later developed Grade V/VI palsy following adjunctive radiotherapy. Seven of the 16 subtotal resections had subsequent radiotherapy or microsurgery. Mean follow up was 26.5 months. In conclusion, subtotal resections lead to good facial nerve outcomes but may require further treatments. Radiation treatment can worsen facial nerve function. There is no standardised use of tumour volumes or accepted guidelines for resection terminology. We propose the use of tumour volumes to define this further.

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“…Before SRS, imaging demonstrated a 5-mm VS located near the fundus. Immediately after treatment, the VS developed transient tumor swelling, which may occur in over half of cases (4). As a result of abrupt growth, the tumor migrated toward the wider medial end of the IAC, partially into the cerebellopontine angle.…”

Section: Discussionmentioning

confidence: 99%