We describe the deconfining critical temperature dependence on the pion mass and on the isospin chemical potential in remarkably good agreement with lattice data. Our framework incorporates explicit dependence on quark masses, isospin and baryonic chemical potentials for the case of two flavors through ingredients from well-known high-and low-energy theories. In the low-energy sector, the system is described by a minimal chiral perturbation theory effective action, corresponding to a hot gas of pion quasiparticles and heavy nucleons. For the high-temperature sector we adopt a simple extension of the fuzzy bag model. We also briefly discuss the effects of mass asymmetry and baryon chemical potential.Introduction. The phase diagram of quark matter has been the object of intense investigation during the last years, and yet several open questions within the thermodynamics of strong interactions still remain unsolved [1,2]. In this quest, Lattice QCD represents the main non-perturbative approach within the full theory [3], always complemented by effective models [4].In this article we investigate the effects of finite quark masses and isospin number on the equation of state of hot and dense strongly interacting matter and on the deconfining phase transition within a framework inspired by chiral perturbation theory (χPT) and lattice results for the pressure and the trace anomaly. The setting we propose is simple and completely fixed by vacuum QCD properties (measured or simulated on the lattice) and lattice simulations of finite temperature QCD. More explicitly, there is no fitting of mass or isospin chemical potential dependence at all. Nevertheless, our findings for the behavior of the critical temperature as a function of both the pion mass and the isospin chemical potential are in remarkably good agreement with lattice data. It is crucial to note that several detailed studies of chiral models failed to describe T c (m π ) [5,6,7], while Polyakov-loop models, whose predictions can be fitted to the lattice points for T c (m π ) [5], cannot at the present form address isospin effects. In this approach, we can also investigate in a straightforward manner the effects of quark-mass asymmetry and nonzero baryon chemical potential, physical cases in which the Sign Problem develops, constraining systematic lattice studies. The predictions within our framework for these regimes which are not yet fully probed by lattice QCD are left for a longer publication (for preliminary results, see [8]). Throughout the present paper, the baryon chemical potential is fixed to zero. It is not our aim in this short paper to provide a complete description of the full richness of the QCD phase diagram. Still, we present a description of the dependence of the critical deconfining temperature on the quark-average mass and on the isospin chemical potential simultaneously.Small quark masses and a nonzero baryon chemical po-