Volume and Connectivity Differences in Brain Networks Associated with Cognitive Constructs of Binge Eating

Hartogsveld, Bart; Quaedflieg, Conny W.E.M.; Ruitenbeek, Peter van; Smeets, Tom

doi:10.1523/eneuro.0080-21.2021

Cited by 10 publications

(12 citation statements)

References 223 publications

(572 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our current findings are consistent with our hypothesis that BED and BN commonly have weak FC between the lateral OFC and inhibitory control-related regions. This is also consistent with previous studies indicating that BED and BN have weakened FC between frontal regions related to cognitive control [ 10 ]. In this study, lateral OFC-DLPFC FC did not show a significant correlation with impulsivity in both BED and BN groups.…”

Section: Discussionsupporting

confidence: 93%

“…Additional effort has been made to elucidate the neurobiological pathophysiology underlying these clinical differences between BED and BN. For instance, previous functional magnetic resonance imaging (fMRI) studies using behavioral tasks have suggested that these two diseases differ in reward processing [ 10 ]. BED and BN have also been found to show different brain activation patterns in relation to reward processing [ 11 ], as well as different reward sensitivity in related brain regions [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Orbitofrontal cortex functional connectivity changes in patients with binge eating disorder and bulimia nervosa

Ahn

Lee

Lee³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

We aimed to define the shared and unshared functional neurobiological underpinnings of binge eating disorder (BED) and bulimia nervosa (BN). These disorders both involve loss of control over binge eating, but differ based on purging behavior and body image distortion. BED and BN have also been found to show differences in brain activation patterns in reward sensitivity. We enrolled 13 and 12 drug-naive and medication-free women with BED and BN, respectively, and 22 age- and sex-matched healthy controls. We performed an orbitofrontal cortex (OFC)-seeded resting-state whole brain functional connectivity (FC) analysis among the groups. In this study, BED patients exhibited significantly higher impulsivity than controls, whereas the difference in impulsivity between BN and controls was not significant. Participants with BED and BN showed weaker FC between the left lateral OFC and the right precuneus than controls. In the BED only group, the FC strength between these regions was negatively correlated with self-reported impulsivity. In both BED and BN, FC between the left lateral OFC and the right dorsolateral prefrontal cortex was weaker than that in controls. In BED, FC between the left medial OFC and the right cerebellar lobule IV was stronger than that of other groups. Our current results suggest similarities and differences between BED and BN in OFC-seeded FC with respect to reward processing. In particular, FC of the OFC in BED patients showed a significant correlation with their high impulsivity, which may reflect a decline in executive control over binge eating.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Orbitofrontal cortex functional connectivity changes in patients with binge eating disorder and bulimia nervosa

Ahn

Lee

Lee³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…However, studies focusing their investigation on binge eating using tasks that probe reward responsiveness specifically for food, find a higher activity of the OFC, ACC as well as striatum during the anticipation and receipt of high-energy-density food, compared with lower activity during the anticipation and receipt of money [16,17]. This is in line with structural data, finding higher volumes in cortical areas, as well as NAc [18 ▪ ,19 ▪ ]. Interestingly, patients with bulimia nervosa may have even higher OFC volume and activation of ACC during food anticipation compared with BED [11,20].…”

Section: Neuroimaging Findings Related To Reward Processing In Binge ...supporting

confidence: 59%

Neuronal activity and reward processing in relation to binge eating

Vrieze,

Leenaerts

2023

Current Opinion in Psychiatry

View full text Add to dashboard Cite

Purpose of review Studies increasingly show the importance of reward processing in binge eating and provide evidence of associated changes in the neurobiological reward system. This review gives an up-to-date overview of the neurobiological substrates of reward processing subconstructs in binge eating. Neural findings are linked to different behavioral theories and the clinical relevance is discussed. Recent findings Increased neural responses in the orbitofrontal cortex, anterior cingulate cortex as well as striatum during anticipation and receipt of food rewards are found in association to binge eating. Increased model-free learning is also found and associated with altered brain reward reactivity. Data in rest report reduced striatal dopamine release and lower frontostriatal connectivity. Mechanisms of onset of binge eating are less clear, but specific personality traits, related to frontostriatal dysconnectivity, probably increase the risk of binge eating onset. Summary Both structural and task-based imaging studies show differences in the neurobiological reward system in binge eating. These changes are linked to specific reward processing, such as altered reward responsiveness to food cues, reinforcement learning, and habitual behavior. Findings are lined with different behavioral theories of binge eating, and a staging model is described, from onset to full illness development. Understanding the specific underlying aberrant reward mechanism in binge eating, associated with different stages of the illness, enables caregivers to focus their treatment more precisely.

show abstract

“…The ILA is also critical when suppression of behavioral action (lever pressing) is required to obtain a sucrose pellet reward (Capuzzo and Floresco 2020). Similar function was highlighted in a recent integrative review of brain network differences in binge eating disorder (BED), where decreased activity in the medial PFC was linked to decreased cognitive control over food-related decisions in BED (Hartogsveld et al 2022). In this regard, ORX signaling within the ventromedial PFC is required in an animal model of cognitive control of feeding.…”

Section: Medial and Lateral Prefrontal Cortexmentioning

confidence: 57%

Sex Differences in Activation of Forebrain Orexin Targets During Hedonic Eating

Parsons

Greiner

Buczek

et al. 2022

Preprint

View full text Add to dashboard Cite

Palatable foods can stimulate appetite without hunger, and unconstrained overeating underlies obesity and binge eating disorder. Women are more prone to obesity and binge eating than men but the neural causes of individual differences are unknown. In an animal model of hedonic eating, a prior study found that females were more susceptible than males to eat palatable food when sated and that the neuropeptide orexin/hypocretisn (ORX) was crucial in both sexes. The current study examined potential forebrain targets of ORX signaling during hedonic eating. We measured Fos induction in the cortical, thalamic, striatal, and amygdalar areas that receive substantial ORX inputs and contain their receptors in hungry and sated male and female rats during consumption of a palatable (high-sucrose) food. During the test, hungry rats of both sexes ate substantial amounts, and while sated males ate much less than hungry rats, sated females ate as much as hungry rats. The Fos induction analysis identified sex differences in recruitment of specific areas of the medial prefrontal cortex (mPFC), paraventricular nucleus of the thalamus (PVT), nucleus accumbens (ACB), and central nucleus of the amygdala (CEA), and similar patterns across sexes in the insular cortex and areas of the ACB and CEA. There was a striking activation of the mPFC in sated males, who consumed the least amount food and unique correlations between the PVT and the CEA in females and the PVT and ACB in males. The study identified key functional circuits that may drive hedonic eating in a sex specific manner.

show abstract

Volume and Connectivity Differences in Brain Networks Associated with Cognitive Constructs of Binge Eating

Cited by 10 publications

References 223 publications

Orbitofrontal cortex functional connectivity changes in patients with binge eating disorder and bulimia nervosa

Orbitofrontal cortex functional connectivity changes in patients with binge eating disorder and bulimia nervosa

Neuronal activity and reward processing in relation to binge eating

Sex Differences in Activation of Forebrain Orexin Targets During Hedonic Eating

Contact Info

Product

Resources

About