Voltammetry of pharmaceuticals using different types of modified electrodes

Abstract

Voltammetrie von Pharmazeutica mit Hilfe verschiedener Typen von modifizierten Elektroden Zusammenfassung. Das elektrochemische Verhalten mehre rer chemisch interessanter Pharmazeutica an verschiedenen K ohlenstoffElektroden wurde mit Hilfe der cyclischen Voltammetrie untersucht. Die Eigenschaften der K ohlen stoffpasteElektrode und der GlaskohlenstoffElektrode wurden geprûft und verglichen mit denjenigen von selbst hergestellten modifizierten Elektroden auf der Basis von kolloidalem Graphit und in einem geeigneten Polymer dis pergiertem Ru6. Das Verhalten des Hexacyanoferrat(II/IIl) Paares wurden als typisch fûr einen Depolarisator angesehen. Es konnte gezeigt werden, daB das Ansprechen der Elektrode von der Art des Substrats deutlich beeinfluBt wird. Die Leistungsfâhigkeit jeder Elektrode wurde an Hand der voltammetrischen K urven der verschiedenen Pharmaca ausgewertet. Summary. Cyclic voltammetry was used to study the electrochemical behaviour of several chemically interesting drugs on différent types of carbon based électrodes. The behaviours of the carbon paste and glassy carbon électrodes were investigated and compared with the results obtained with homemade new types of modified électrodes based on colloïdal graphite or carbon black dispersed in a suitable polymer. The behaviour of the couple hexacyanoferrate(Il/ III) has been reported as a typical model of depolarizer. It has been shown that électrode responses were markedly influenced by the nature of the substrate. Performances of each électrode have been evaluated with regard to the shape of the voltammetrie curves obtained during the investigation of thèse drugs.

Electrochemical Behavior of Chalcone at a Glassy Carbon Electrode and Its Analytical Applications

“…In this connection, a clinically effective antitumor derivative of chalcone (calicheamicin) has stimulated the investigators to concentrate their studies on chalcones and related compounds [3]. Electrochemical methods have proved to be very sensitive for the determination of organic molecules, including drugs and related molecules in pharmaceutical dosage forms and biological fluids [4][5][6][7][8]. The advance in experimental electrochemical techniques in the field of analysis of drugs is due to their simplicity, low cost and relatively short analysis time when compared with the other techniques.…”

An Affordable and Efficient Graphite‐Coated Electrode for the Voltammetric Determination of Catechol

“…While colloidal graphite holds promise for electrode modification, its application in the field of the electrochemical analysis is relatively limited compared to other electrode materials. Kauffmann et al [21][22][23] detail the fabrication of carbon, aluminum, copper, and platinum electrodes sprayed with a colloidal suspension of graphite particles dispersed in poly(methyl methacrylate). They explore the electrochemical behavior of specific pharmacological compounds and demonstrate the electrodes' efficacy for their quantification.…”

Square Wave Voltammetric Determination of 2-Thiouracil in Pharmaceuticals and Real Samples Using Glassy Carbon Electrode

“…The advance in experimental technique in the field of analysis of drugs is due to their simplicity, low cost, and relatively short analysis time when compared with the other techniques. Electrochemical methods have proved to be very sensitive for the determination of organic molecules, including drugs and related molecules in pharmaceutical dosage forms and biological fluids [11][12][13][14][15]. Carbon electrodes, especially glassy carbon electrodes (GCE), are widely used in the electrochemical investigations because of their low background current, wide potential windows, chemical inertness, low cost, and suitability for detection of various organic and biological compounds.…”