Voltammetric studies on the potent carcinogen, 7,12-dimethylbenz[a]anthracene: Adsorptive stripping voltammetric determination in bulk aqueous forms and human urine samples and detection of DNA interaction on pencil graphite electrode

Yardım, Yavuz; Keskin, Ertuğrul; Levent, Abdulkadir; Özsöz, Mehmet; Şentürk, Zühre

doi:10.1016/j.talanta.2009.09.035

Cited by 60 publications

(25 citation statements)

References 41 publications

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“…Positive shifts were observed in the peak potentials for the bases, which were more pronounced for DO1 (6.0 and 8.0 mV for the guanine and adenine moieties, respectively) than for DR1 (3.0 and 5.0 mV, respectively). A positive shift in peak potential when low molecular mass molecules interact with DNA can result from intercalative binding involving stacking interactions [28,50]. In previous work [51], we suggested that aromatic amines are generated during the reduction of DO1.…”

Section: Interaction Of Immobilized Dsdna With the Disperse Dyes And mentioning

confidence: 92%

Evaluation of the interactions of DNA with the textile dyes Disperse Orange 1 and Disperse Red 1 and their electrolysis products using an electrochemical biosensor

Uliana

Garbellini

Yamanaka

2013

Sensors and Actuators B: Chemical

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Section: Interaction Of Immobilized Dsdna With the Disperse Dyes And mentioning

confidence: 92%

Evaluation of the interactions of DNA with the textile dyes Disperse Orange 1 and Disperse Red 1 and their electrolysis products using an electrochemical biosensor

Uliana

Garbellini

Yamanaka

2013

Sensors and Actuators B: Chemical

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“…The voltammetry of 7,12-dimethylbenz[a]anthracene (DMBA), alkyl-substituted PAH compound, in aqueous and nonaqueous media has been described in a very recent work of our group [45].…”

Section: Resultsmentioning

confidence: 99%

Voltammetry of Benzo[a]pyrene in Aqueous and Nonaqueous Media: Adsorptive Stripping Voltammetric Determination at Pencil Graphite Electrode

2010

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A detailed study of the electrochemical oxidation of Benzo[a]pyrene (BaP) at the glassy carbon and pencil graphite electrodes was carried out in aqueous and nonaqueous media. Using square-wave stripping mode, the compound yielded a well-defined voltammetric response at pencil graphite electrode in acetate buffer, pH 4.8 at þ 1.13 V (vs. Ag/ AgCl) (a preconcentration step being carried out at a fixed potential of þ 0.70 V for 180 s). The process could be used to determine BaP concentrations in the range 0.25 -1.25 mM, with a detection limit of 0.027 mM (6.82 mg L À1). The applicability to assay of spiked human urine samples was also illustrated.

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“…A better developed peak current was achieved over the potential range of (−0.65 to −0.75 V) because of an increase of the accumulation rate due to the more favorable alignment of the molecules by the electric field at the electrode solution interface. 44,45 However at more negative potentials, the peak current decreased indicating that the reactant species were no longer strongly adsorbed at potentials where the mercury is negatively charged with respect to the point of zero charge potential. 46 Therefore, a preconcentration potential of −0.7 V (vs. Ag/AgCl/KCl s ) was chosen for the rest of the present analytical study.…”

Section: Effect Of Preconcentration Conditionsmentioning

confidence: 99%

Adsorptive stripping voltammetry determination of the hormone therapy Raloxifene HCl in formulation and human serum

Ghoneim¹,

Hassanein²,

Salahuddin³

et al. 2012

J. Braz. Chem. Soc.

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Raloxifeno HCl (RLX) adsorveu fortemente na superfície do eletrodo de mercúrio numa monocamada com cobertura superficial de 5,724 × 10 −10 mol cm -2 . Dois métodos voltamétricos de redissolução catódico adsortivo com varredura linear e onda quadrada (LS-AdCSV e SW-AdCSV, respectivamente) precisos, rápidos e livres de extração são descritos para determinação em nível de traço de RLX em solução, em formulação comercial e soro humano. Limites de quantificação (LOQ) de 2,0 × 10 -9 e 5,0 × 10 -11 mol L −1 de RLX em solução e 4,0 × 10 -9 e 1,0×10 -10 mol L −1 em soro humano enriquecido foram obtidos pelos métodos descritos LS-AdCSV e SW-AdCSV, respectivamente. Interferências de alguns excipientes comuns, íons metálicos e drogas coadministradas foram insignificantes. LOQ adquidos pelos métodos são baixos assim como oferecem boas possibilidades de determinação de drogas em preparações farmacológicas de baixa dosagem. Contudo, o método SW-AdCSV descrito é sensível suficiente em ensaios de drogas também em soro humano.Raloxifene HCl (RLX) was found to strongly adsorb onto surface of the mercury electrode in a monolayer surface coverage of 5.724 × 10 −10 mol cm -2 . Two precise, rapid and extractionfree linear sweep and square wave adsorptive cathodic stripping voltammetry (LS-AdCSV and SW-AdCSV, respectively) methods are described for trace quantitation of RLX in bulk form, commercial formulation and human serum. Limits of quantification (LOQ) of 2.0 × 10 -9 and 5.0 × 10 -11 mol L −1 RLX in bulk form and 4.0 × 10 -9 and 1.0 × 10 -10 mol L −1 RLX in spiked human serum were achieved by the described LS-AdCSV and SW-AdCSV methods, respectively. Insignificant interferences from some common excipients, metal ions and co-administrated drugs were obtained. LOQ achieved by the methods are low as well as they offer good possibilities for determination of drug in low-dosage pharmaceutical preparations. However, the SW-AdCSV method described is sensitive enough to assay the drug also in human serum.

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Voltammetric studies on the potent carcinogen, 7,12-dimethylbenz[a]anthracene: Adsorptive stripping voltammetric determination in bulk aqueous forms and human urine samples and detection of DNA interaction on pencil graphite electrode

Cited by 60 publications

References 41 publications

Evaluation of the interactions of DNA with the textile dyes Disperse Orange 1 and Disperse Red 1 and their electrolysis products using an electrochemical biosensor

Evaluation of the interactions of DNA with the textile dyes Disperse Orange 1 and Disperse Red 1 and their electrolysis products using an electrochemical biosensor

Voltammetry of Benzo[a]pyrene in Aqueous and Nonaqueous Media: Adsorptive Stripping Voltammetric Determination at Pencil Graphite Electrode

Adsorptive stripping voltammetry determination of the hormone therapy Raloxifene HCl in formulation and human serum

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