Voltammetric sensor for secretolytic agent ambroxol at titanium dioxide nanoparticles modified electrode

Electrocatalytic Oxidation Processes for Treatment of Halogenated Organic Pollutants in Aqueous Solution: A Critical Review

“…Ambroxol is an effective drug for the treatment of respiratory diseases and has a strong antioxidant effect . There are many reports on electro­chemical oxidation of ambroxol. − The therapeutic mechanism of ambroxol is closely related to its antioxidant and scavenging properties toward certain reactive oxygen species. Sun et al found one possible oxidation mechanism of ambroxol via electro-polymerization using a carbon paste anode (Figure A).…”

“…Anilino radicals (II) dimerize via N–C4 coupling to form a 4-aminodiphenylamine derivative (III) with one bromide atom broken off. This reaction mechanism is consistent with that reported by Naik et al In the ambroxol oxidation process, active oxygen plays a different role. The hydroxyl radicals and superoxide anion radical (O 2 • – ) can directly oxidize ambroxol, while H 2 O 2 can only react with the intermediate 4-aminodianiline derivatives after ambroxol oxidation.…”

“…Anilino radicals (II) dimerize via N− C4 coupling to form a 4-aminodiphenylamine derivative (III) with one bromide atom broken off. This reaction mechanism is consistent with that reported by Naik et al 96 In the ambroxol 99 also considered that the electrochemical reactions of ambroxol at the surface of ruthenium-doped TiO 2 nanoparticles/reduced graphene oxide/carbon paste electrode anode involved the transfer of two protons and two electrons, and the reactions occurred at the secondary amine group, not at the primary amine group (Figure 3B).…”