Voltammetric quantitation of nitazoxanide by glassy carbon electrode

Jain, Rajeev; Yadav, Rajeev Kumar; Rather, Jahangir Ahmad

doi:10.1016/j.jpha.2013.07.005

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Table III compares the detection limit of the proposed method with the other reported methods. 28,30 As summarized in …”

Section: Resultsmentioning

confidence: 99%

“…25 The review of literature revealed that few methods have been reported for the determination of nitazoxanide in pharmaceutical formulations viz., spectrophotometric, 26 liquid chromatography, 27 reverse phase high performance chromatography (RP-HPLC), 28 spectrophotometric with high performance chromatography 29 and voltammetric. 30,31 Modern electroanalytical techniques are becoming increasingly important for the determination of pharmaceutically z E-mail: rajeevjain54@yahoo.co.in significant compounds. [32][33][34][35] Electroanalytical techniques are time saving, cost effective, provide qualitative and quantitative information.…”

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confidence: 99%

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Electrocatalytic Detection and Quantification of Nitazoxanide Based on Graphene- Polyaniline (Grp-Pani) Nanocomposite Sensor

Jain

Tiwari

Karolia

2014

J. Electrochem. Soc.

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An ultrasensitive voltammetric sensor based on the synergistic effect of graphene (Grp)-Polyaniline (Pani) hybrid film for electrochemical sensing of antiprotozoal nitazoxanide has been developed. The electrocatalytic performance and morphology of fabricated hybrid film sensor were characterized by square wave voltammetry (SWV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The influence of various parameters such as pH, effect of scan rate, and loading of Pani-Grp hybrid film onto GCE on electroanalytical performance of the developed sensor was investigated. Under optimized conditions, reduction peak current was linear over the wide concentration range from 10-70 μg/mL with correlation coefficient of 0.998. The lower limit of detection (LOD) and the lower limit of quantification (LOQ) were found to be 2.2 μg/mL and 6.9 μg/mL. A novel electrocatalytic activity and the influence of hybrid film results in good characteristics such as high electroactive surface area, excellent electrochemical performance, anti-interferent ability, good stability, fast response, good reproducibility and long-term stability which are the promising features of the biosensing applications.Intrinsically conducting polymers, such as polyaniline (Pani), polypyrrole (PPY) and polythiophene (PT), have received considerable interest due to their fascinating electrical, optical and electrochemical properties derived from the conjugated p-electron system. 1 Composites of conducting polymers permit a facile flow of electronic charges across the polymer matrix during electrochemical processes. Polymer nanocomposite materials are important due to their extraordinary properties, which arise from the synergism between the properties of the components. 2-5 Among them, Pani shows the most promising material for electrical applications due to the existence of various oxidation structures (doped state) as well as due to their easy synthesis, good processibilty, high electrical conductivity, good chemical, thermal stability and environmental stability. 6-8 Pani shows attractive properties for use in chemical sensor and bio-sensors. 9,10 Pani has high specific surface area which would provide high sensitivity and fast response. 11 Graphene have extraordinary electronic transport properties and high electrocatalytic activities. 12-14 Graphene have been investigated as electrode materials in optoelectronic devices, electrochemical super-capacitors, fabricated field-effect transistors, and constructed ultrasensitive chemical sensors, such as pH sensors, gas sensors, and biosensors. 15 Graphene has become a material of choice in various research fields due to its characteristics of high electrical conductivity and large surface area. 16 Recently, graphene based materials have been used as an advanced nano electro catalyst for fabrication of electrochemical sensors. [17][18][19] The combination of the Grp with Pani highly enhances the electrochemical performance because Grp serves as a supporting material and provides a l...

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“…Table III compares the detection limit of the proposed method with the other reported methods. 28,30 As summarized in …”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Electrocatalytic Detection and Quantification of Nitazoxanide Based on Graphene- Polyaniline (Grp-Pani) Nanocomposite Sensor

Jain

Tiwari

Karolia

2014

J. Electrochem. Soc.

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“…The accuracy of an analytical method expresses the closeness of agreement between the value which is accepted either as a conventional true value or an accepted reference value and the found value [55][56][57][58]. The accuracy of the tested methods was estimated taking into consideration the percentage relative error (Err) calculated according to the following equation:…”

Section: Accuracymentioning

confidence: 99%

Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals

Goclik¹,

Chrześcijańska²,

Kuśmierek³

et al. 2019

Port. Electrochim. Acta

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Electrochemical oxidation of N-acetyl-p-aminophenol (AAP) and selected pharmaceutical products containing AAP is described in this study. Investigations were carried out at Pt electrode, with the application of cyclic (CV) and differential pulse (DPV) voltammetry. AAP was irreversibly oxidized in, at least, one electrode step, with potentials lower than the potential at which oxygen evolution started. Electrochemical methods based on voltammetric techniques (DPV and CV) have been developed for AAP determination in commercial pharmaceutical drugs. AAP content in pharmaceuticals was determined on the base of dependences of current intensity (electroanalytical measurements) and absorbance (UV-VIS spectra). The obtained results using both methods were in good agreement. The validation of CV, DPV and spectrophotometric methods is also presented. Spectrophotometric and voltammetric responses linearly increased with increasing AAP concentrations, in the range from 0.2 to 5 mmol L-1 , with a correlation coefficient of 0.997 (UV-VIS), 0.999 (CV) and 0.998 (DPV). Both electrochemical methods are simple, reliable and sufficiently accurate and precise for AAP quantification in commercial drug samples (tablets). The analysis took only 5 minutes of manual operation, including Pt electrode pre-treatment.

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“…The drug must be monitored for quality assurance in preparations and to achieve the best therapeutic doses while limiting the risk of toxicity [3]. There are few analytical literature reviews for estimation of NTZ such as spectrophotometry [4][5][6], HPLC [7][8][9], HPTLC [4,10,11], and stripping voltammetry [12][13][14][15]. Also, some bioanalytical methods for quantitation of NTZ were reported [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Turn-On–Type Fluorescence Resonance Energy Transfer Eco-friendly Method for Nitazoxanide Quantification in Pharmaceutical Dosage Form and Spiked Plasma: Evaluation of Greenness Profile Using Different Assessment Tools

et al. 2022

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A brand-new class of anti-infective drugs that work against bacteria, viruses, and protozoan parasites is nitazoxanide and related thiazolides. Thiazolides have also been shown to cause cell cycle arrest and apoptotic cell death in cancer cells in recent years. In this study, an eco-friendly, spectrofluorimetric technique that is verified, easy, and sensitive has been proposed for quantifying nitazoxanide (NTZ), a broad-spectrum antiparasitic drug. When NTZ is reduced with zinc (Zn) powder in an acidic media, a highly fluorescent product is produced. To get the highest sensitivity, different experimental conditions impacting the response were examined and optimized. Following excitation at 299 nm, scanning of the fluorescent product was done at 440 nm. The intensity of the fluorescence was proportional to the drug concentration in the range of 0.1–0.6 μg/mL. The approach was validated according to International Conference on Harmonization (ICH) guidelines, and the outcome was satisfactory. The detection and quantitation limits were calculated to be 0.013 and 0.038 μg/mL, respectively. The suggested technique was successful in analyzing commercially available NTZ dosage forms. Furthermore, the proposed technique was used to assess NTZ levels in human plasma and it was bio-analytically validated according to European Medicines Agency (EMA) guidelines. The suggested method can be used in quality control laboratories as well as in pharmacokinetic studies. In order to picture the green profile of the developed method, four greenness assessment tools have been applied. National Environmental Methods Index (NEMI), analytical Eco-Scale Assessment (ESA), Green Analytical Procedure Index (GAPI) and Analytical Greenness metric (AGREE) are the relatively most widely used metrics. So, they were utilized to perform a detailed greenness comparison between the proposed method and some of the reported methods for the determination of NTZ. The developed method was found to be an excellent green method with the highest AGREE score.

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Voltammetric quantitation of nitazoxanide by glassy carbon electrode

Cited by 12 publications

References 9 publications

Electrocatalytic Detection and Quantification of Nitazoxanide Based on Graphene- Polyaniline (Grp-Pani) Nanocomposite Sensor

Electrocatalytic Detection and Quantification of Nitazoxanide Based on Graphene- Polyaniline (Grp-Pani) Nanocomposite Sensor

Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals

A Turn-On–Type Fluorescence Resonance Energy Transfer Eco-friendly Method for Nitazoxanide Quantification in Pharmaceutical Dosage Form and Spiked Plasma: Evaluation of Greenness Profile Using Different Assessment Tools

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