Voltammetric quantification of a nonsteroidal anti-inflammatory agent diflunisal based on the enhancement effect of cationic surfactant on boron-doped diamond electrode

Abstract

The present work describes a simple, fast, and inexpensive voltammetric method for diflunisal measurement using a non-modified boron-doped diamond (BDD) electrode. The oxidation of the agent was irreversible and presented a diffusion‐controlled process. The sensitivity of the square wave voltammetric measurements were significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB), was present in the supporting electrolyte solution. Using square-wave mode, a linear response was obtained for diflunisal quantification in 0.1 mol L-1 phosphate buffer solution (pH 2.5) solution containing 5×10-5 mol L-1 CTAB at +1.07 V (vs. Ag/AgCl) (after 30 s accumulation under open-circuit conditions). Linearity was found for 0.05 to 2.0 μg mL-1 (2.0×10-7-8.0×10-6 mol L-1) with a detection limit 0.013 μg mL-1 (5.2×10-8 mol L-1). The developed approach could be used for the quantification of diflunisal in pharmaceutical formulations.

Electrochemical Determination of Flavonoid Fisetin in Commercial Dietary Supplements Using a Boron‐Doped Diamond Electrode

“…[25] On the other hand, the analytical performance of this electrode may vary depending on the boron doping level, [26] surface morphology and presence of impurities, surface tip, and applied anodic or cathodic pretreatment steps. [25,[27][28][29][30] Our research group has conducted much research using the BDD electrode in the electrochemical analysis of drugs [31][32][33][34] and some polyphenolic compounds. [35,36] This paper is the first study to elucidate the electrochemical oxidation behavior of the flavonoid FST using BDD electrode surface.…”

Voltammetric determination of anti-malarial drug amodiaquine at a boron-doped diamond electrode surface in an anionic surfactant media

“…This aided in the adsorption of the analyte to the surface of the electrode. [34][35][36][37][38][39][40][41][42] The selection of the working electrode is essential in the fabrication of an electrochemical sensor because the electrode type significantly affects the sensitivity, cost, stability, and selectivity. 29,43 The BDD electrode is a chemically modified, innovative electrode material that offers a wide range of work in the electrochemistry field.…”