Voltammetric oxidation of vinblastine and related compounds

Electrooxidation of p-Chloroaniline at Gold Electrode

“…Our voltammetric results in terms of peak (or half wave) potential dependence on scan rate and concentration of p-chloroaniline suggest that elecrtrochemical oxidation of p-chloroaniline at gold anode in acetonitrile involves surface electrodimerization. This interpretation is in agreement with earlier studies of the electrochemical oxidation of aromatic amines (15,19,(23)(24).…”

Electrochemical and Electron Spectroscopic Studies of Highly Polished Glassy Carbon Electrodes

“…If deprotonation is assumed to follow electron transfer, a shift in Ep would be expected (35), but a change in wave shape is unlikely. Further evidence against a surface base-catalyzed mechanism is the behavior of vindoline and vinblastine, whose oxidations at pH 5.6 involve deprotonation before electron transfer (33) but whose voltammetric peaks were not affected at highly polished glassy carbon. A reasonable alternative involves hydrogen-atom transfer to catalytic groups on the electrode, as proposed for oxidations of certain ruthenium complexes and catechol on electrochemically activated glassy carbon (8).…”

Voltammetry of an Anti-cancer Drug

“…Results obtained by cyclic voltammetry as well as by pulse techniques suggest that electron transfer is preceded by deprotonation and followed by additional chemical reactions. Products of the electrode processes form mechanically unstable films on the electrode surface (3).…”