Voltammetric determination of nitrites in meat products after reaction with ranitidine producing 2-methylfuran cation

Flow injection analysis of ranitidine based on derivatization reaction producing 2‐Methylfuran cation as a sensitive and selective amperometric detector

“…The stoichiometric ratio between ranitidine and nitrite ions was studied by measuring the absorbance at 460 nm with continuous changes of stoichiometric ratios and it was found that the molar ratio between ranitidine and nitrite ion to be 1 : 1 see Figure 3. Based on previous research on the mechanism of the reaction [1] of ranitidine deamination the nitroso dimethyl amine is formed as a result of the reaction, and from this we can conclude that the stoichiometric ratio from the experimental data stands completely.…”

“…Ranitidine hydrochloride appears as crystalline powder, practically odourless and with a colour of white to pale yellow. It is commonly used to treat peptic ulcer disease, gastroesophageal reflux disease, Zollinger-Ellison syndrome and other conditions where inhibition of gastric acid secretion is beneficial [1][2][3][4]. This substituted aminoalkylfuran derivative is more potent than the cimetidine as an inhibitor of gastric acid secretion, and it is marketed in a range of dosage forms including tablets, syrups and injectable solutions.…”

“…

A new electrochemical sensor in a flow injection system is developed for the determination of ranitidine in pharmaceutical formulations. The method is based on the deamination reaction of ranitidine in an acidic environment in the presence of nitrite ions producing the electroactive species 2-methylfuran and releasing nitrosamine [1]. A wide linear range of ranitidine from 4.4 to 6000 mg L À 1 , with correlation coefficient R 2 = 0.996 and the detection limit 1.3 mg L À 1 was obtained.

…”

Sensing Food Contaminants: Advances in Analytical Methods and Techniques

“…157 In addition, the many straightforward ways to measure moving electrons and the inherently quantitative nature of electrochemical measurements support the great potential for electrochemical sensors. A wide range of electrochemical sensors has been developed specifically for the detection of food contaminants, including impedimetric aptasensors, 158−160 square-wave voltammetric electrodes, 161,162 and amperometric electrodes. 163,164 In this review, we focus on field-effect transistor (FET) sensors based on their ability to reach very low limits of detection and their high potential for onsite use as compared to other electrochemical sensors.…”

“…In addition, the many straightforward ways to measure moving electrons and the inherently quantitative nature of electrochemical measurements support the great potential for electrochemical sensors. A wide range of electrochemical sensors has been developed specifically for the detection of food contaminants, including impedimetric aptasensors, − square-wave voltammetric electrodes, , and amperometric electrodes. , In this review, we focus on field-effect transistor (FET) sensors based on their ability to reach very low limits of detection and their high potential for on-site use as compared to other electrochemical sensors . This technology has been employed to detect five of the six classifications of food contaminants, missing only parasites, which tend to be too large compared to the surface of the FET for the method to be effective. − FET sensors detect changes in potential or current across a conductive channel between an oxide insulator and a semiconductor.…”