Voltammetric determination of chlorpromazine hydrochloride

Abstract

The electrochemical behaviour of chlorpromazine hydrochloride (CPZ-HCI) in sulphuric acid was investigated voltammetrically using ruthenium electrodes and it was subsequently determined by the same method. From the recorded voltammograms it was concluded that CPZ-HCI can be determined in the concentration range 2 x 10(-4)-8 x 10(-4) M (71-284. 3 micrograms ml-1). The proposed voltammetric method was applied to the determination of CPZ-HCI in tablets used for neuroleptic purposes in Turkey; the amount of effective compound was found to be within the ranges given for a pharmacopoeial procedure.

Carbon electrodes in amine analysis: Effect of chemically modified carbon surfaces on signal quality and reproducibility

“…Enhancement of wave intensity was reported after anodizing in phosphate buffer at 1.6V at GCE [27]. Further investigation has been done by Takamura [28], Zimova [29] and Dermis [30]. Chlorpromazine was measured in dilute sulfuric acid.…”

Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode

“…Pt, Ru, Au). [17][18][19] In order to establish the precision of the proposed methods, experiments were conducted verifying the repeatability of measurement results obtained within one day and on five successive days. Then, a statistical analysis of the obtained results was carried out.…”

“…16 Voltammetric methods described in the literature make use of metallic electrodes (e.g. Pt, Au, Ru) [17][18][19] and different carbon electrodes. [20][21][22] Some works are also described in which phenothiazine derivatives are electrocatalytically oxidized in the presence of methylene blue or alizarin red S used as mediators.…”

Disposable solid state probe for optical screening of chlorpromazine

“…These include spectrofluorimetry [5], chemiluminescence [6], high performance liquid chromatography [7][8][9][10], voltammetry [11][12][13], differential pulse stripping voltammetry [14][15][16][17], polarography [18,19], and electrophoresis [20][21][22][23][24], visible spectrophotometry [25][26][27][28][29] and a combination of the previous ones [30]. These methods exhibit excellent selectivity, but require expensive instrumentation and are unsuitable for screening in the local under survey.…”