Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations on a Boron Doped Diamond Electrode

Vedenyapina, M. D.; Kazakova, M. M.; Скундин, А. М.

doi:10.1134/s0036024419060335

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…The relative standard deviation was measured at two levels of concentration mass of AA, i.e., 45 μg L −1 and 158 μg L −1 and calculated to be 4.2 % and 3.8%, respectively, values indicating the good reproducibility of the proposed assay. The linear detection region of AA in the present study is in several cases better than that determined by the corresponding electrochemical techniques in the literature [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 45 ] On the other hand, the detection limit of the current analytical AA detection methodology is better compared to the majority of those determined with the other corresponding electrochemical techniques available in the literature, with the exception that it is in the same magnitude of Zhao et 2019 [ 20 ], Kaçar and Erden 2020 [ 2 ], Broncová et al 2021 [ 34 ], Pekin et al [ 45 ], as it can be seen from Table 1 .…”

Section: Analytical Performance Of the Proposed Assaymentioning

confidence: 48%

“…Moreover, Pt modified electrodes with 3,4-diaminobenzoic acid and neutral red [ 34 ] or screen-printed electrodes (SPE) [ 35 , 36 , 37 ]. Furthermore, boron-dropped electrodes were also used [ 38 ]. Meanwhile, miniaturized nanoporous gold (NPG) [ 39 ], platinum functionalized with commercial pre-polymers electrodes [ 40 ] and yttrium hexacyanoferrate microflowers on freestanding three-dimensional graphene substrates [ 41 ] were also utilized in the detection of AA.…”

Section: Introductionmentioning

confidence: 99%

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Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex

2021

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Voltammetric techniques have been considered as an important analytical tool applied to the determination of trace concentrations of many biological molecules including ascorbic acid. In this paper, ascorbic acid was detected by square wave voltammetry, using graphene oxide paste as a working electrode, modified by a film of a manganese(II) complex compound. Various factors, such as the effect of pH, affecting the response characteristics of the modified electrode were investigated. The relationship between the peak height and ascorbic acid concentration within the modified working electrode was investigated, using the calibration graph. The equation of the calibration graph was found to be: I = 0.0550γac + 0.155 with R2 = 0.9998, where I is the SWV current and γac is the mass concentration of ascorbic acid. The LOD and LOQ of the proposed method were determined to be 1.288 μg/L and 3.903 μg/L, respectively. Several compounds, such as riboflavin, biotin, and ions, such as Fe and Cu, were tested and it seemed that they did not interfere with the analytic signal. The proposed procedure was successfully applied in the determination of ascorbic acid in Rosa canina hips.

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Section: Analytical Performance Of the Proposed Assaymentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex

2021

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“…A comparison between the developed voltammetric method and some of the common analytical and voltammetric methods for ascorbic acid determination in terms of detection limit and the linear range was displayed in Table 3. As shown, the iodine-coated platinum electrode exhibited a lower detection limit than that of other voltammetric methods (34)(35)(36). In contrast, the obtained linear range was convenient and extended compared to other voltammetric methods.…”

Section: Pharmaceutical Preparation Analysismentioning

confidence: 82%

Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode

Amayreh

Hourani²,

Hourani³

2021

Vitae

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Background: Despite the high reactivity of the platinum electrode, the iodine-coated platinum electrode shows obvious inertness toward adsorption and surface processes. For that, iodine-coated platinum electrodes accommodate themselves to interesting voltammetric applications. Objectives: This study reports using the modified iodine-coated polycrystalline platinum electrode as a voltammetric sensor for ascorbic acid determination in pharmaceutical formulations. Methods: The developed voltammetric method based on recording cyclic voltammograms of ascorbic acid at iodine-coated electrode The optimized experimental parameters for the determination of ascorbic acid were using 0.1 M KCl as a supporting electrolyte with a scan rate of 50mV/s. Results: The anodic peak related to ascorbic acid oxidation was centered at nearly 0.28V. An excellent and extended linear dependence of the oxidative peak current on the concentration of ascorbic acid was observed in the range 2.84x10-3 - 5.68 mM. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.0 µM and 3.01 µM, respectively, attesting to the method’s sensitivity. The investigation for the effect of potential interference from multivitamin tablet ingredients (vitamins B1, B6, B12, folic acid, citric acid, sucrose, glucose, and zinc) indicated specific selectivity toward ascorbic acid and the absence of any electrochemical response toward these components. Recovery results in the range 98.93±2.78 - 99.98±5.20 for spiked standard ascorbic acid in pharmaceutical formulations further confirmed the potential applicability of the developed method for the determination of ascorbic acid in real samples. Conclusions: The developed method was successfully applied to the analysis of ascorbic acid (vitamin C), and the obtained results were in good agreement with the labeled values; besides, the statistical tests indicated no significant difference at p=0.05 with a 95% confidence level.

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“…In a study by Vedenyapina et al [163], SWV and CV were carried out to analyze the electrochemical properties of AA on a boron-doped diamond (BDD) electrode. They found that the voltammetric response signal can be used to quantify AA content in the aqueous solution.…”

Section: Square Wave Voltammetry Methods To Detect Ascorbic Acidmentioning

confidence: 99%

An overview of recent advances in the detection of ascorbic acid by electrochemical techniques

Mohabis¹,

Fazeli²,

Amini³

et al. 2022

J. Electrochem. Sci. Eng.

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Ascorbic acid is a water-soluble vitamin essential in human nutrition, an antioxidant, a scavenger of free radicals in biological systems, and a cofactor of several enzymes. The reference range for ascorbic acid in healthy people is 6 - 20 mg L-1. The variable concentration of ascorbic acid within biology fluids was found in clinical investigations to be a metric for assessing the exact amount of oxidative stress in the body's metabolism. Electroanalytical techniques are a group of methods in analytical chemistry, especially with extensive application in pharmaceutical industries. These techniques attracted further attention due to their unique characteristics, such as reduced sample or solvent consumption, high analysis speed, low operating cost, and high sensitivity, which made them suitable candidates for replacement or supplementation for spectrophotometry and separation approaches. The purpose of this article is to scrutinize the mechanisms and applications of current electroanalytical methods, including amperometric techniques, square wave voltammetry, differential pulse voltammetry and cyclic voltammetry, in their applications in pharmaceutical analysis for the detection of ascorbic acid. Related examples have been cited in the form of selected studies.

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Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations on a Boron Doped Diamond Electrode

Cited by 6 publications

References 15 publications

Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex

Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex

Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode

An overview of recent advances in the detection of ascorbic acid by electrochemical techniques

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