Voltammetric Detection of Biological Molecules Using Chopped Carbon Fiber

Sugawara, Kazuharu; Yugami, Asako; Kojima, Akira

doi:10.2116/analsci.26.1059

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Since CFs have a local structure similar to graphite, they are good electrical conductors with resistivity in the range from 9.5•10 −6 to 18•10 −6 Ωm. They can be utilized in voltammetric recognition of biological molecules [366], to make electrodes for neural recording [367,368], or the stimulation of cardiomyocytes [369]. Concerning regeneration medicine, CFs are mainly utilized to fabricate scaffolds for tissue repair.…”

Section: Carbon Fibersmentioning

confidence: 99%

Functionalization of Carbon Nanomaterials for Biomedical Applications

Liu

Speranza

2019

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Over the past decade, carbon nanostructures (CNSs) have been widely used in a variety of biomedical applications. Examples are the use of CNSs for drug and protein delivery or in tools to locally dispense nucleic acids to fight tumor affections. CNSs were successfully utilized in diagnostics and in noninvasive and highly sensitive imaging devices thanks to their optical properties in the near infrared region. However, biomedical applications require a complete biocompatibility to avoid adverse reactions of the immune system and CNSs potentials for biodegradability. Water is one of the main constituents of the living matter. Unfortunately, one of the disadvantages of CNSs is their poor solubility. Surface functionalization of CNSs is commonly utilized as an efficient solution to both tune the surface wettability of CNSs and impart biocompatible properties. Grafting functional groups onto the CNSs surface consists in bonding the desired chemical species on the carbon nanoparticles via wet or dry processes leading to the formation of a stable interaction. This latter may be of different nature as the van Der Waals, the electrostatic or the covalent, the π-π interaction, the hydrogen bond etc. depending on the process and on the functional molecule at play. Grafting is utilized for multiple purposes including bonding mimetic agents such as polyethylene glycol, drug/protein adsorption, attaching nanostructures to increase the CNSs opacity to selected wavelengths or provide magnetic properties. This makes the CNSs a very versatile tool for a broad selection of applications as medicinal biochips, new high-performance platforms for magnetic resonance (MR), photothermal therapy, molecular imaging, tissue engineering, and neuroscience. The scope of this work is to highlight up-to-date using of the functionalized carbon materials such as graphene, carbon fibers, carbon nanotubes, fullerene and nanodiamonds in biomedical applications.

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Section: Carbon Fibersmentioning

confidence: 99%

Functionalization of Carbon Nanomaterials for Biomedical Applications

Liu

Speranza

2019

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“…Carbon fibers have been studied biologically and used clinically in a wide variety of applications. By electrical conductivity, carbon fibers have been used for voltammetric recognition of biological molecules [ 24 ]. Also, a carbon fiber electrode has been used for neural recording [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Fiber Biocompatibility for Implants

Petersen

2016

Fibers

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Carbon fibers have multiple potential advantages in developing high-strength biomaterials with a density close to bone for better stress transfer and electrical properties that enhance tissue formation. As a breakthrough example in biomaterials, a 1.5 mm diameter bisphenol-epoxy/carbon-fiber-reinforced composite rod was compared for two weeks in a rat tibia model with a similar 1.5 mm diameter titanium-6-4 alloy screw manufactured to retain bone implants. Results showed that carbon-fiber-reinforced composite stimulated osseointegration inside the tibia bone marrow measured as percent bone area (PBA) to a great extent when compared to the titanium-6-4 alloy at statistically significant levels. PBA increased significantly with the carbon-fiber composite over the titanium-6-4 alloy for distances from the implant surfaces of 0.1 mm at 77.7% vs. 19.3% (p < 10−8) and 0.8 mm at 41.6% vs. 19.5% (p < 10−4), respectively. The review focuses on carbon fiber properties that increased PBA for enhanced implant osseointegration. Carbon fibers acting as polymer coated electrically conducting micro-biocircuits appear to provide a biocompatible semi-antioxidant property to remove damaging electron free radicals from the surrounding implant surface. Further, carbon fibers by removing excess electrons produced from the cellular mitochondrial electron transport chain during periods of hypoxia perhaps stimulate bone cell recruitment by free-radical chemotactic influences. In addition, well-studied bioorganic cell actin carbon fiber growth would appear to interface in close contact with the carbon-fiber-reinforced composite implant. Resulting subsequent actin carbon fiber/implant carbon fiber contacts then could help in discharging the electron biological overloads through electrochemical gradients to lower negative charges and lower concentration.

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Inorganic fibers for biomedical engineering applications

Liu

Yao

et al. 2019

Materials for Biomedical Engineering

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Voltammetric Detection of Biological Molecules Using Chopped Carbon Fiber

Cited by 4 publications

References 18 publications

Functionalization of Carbon Nanomaterials for Biomedical Applications

Functionalization of Carbon Nanomaterials for Biomedical Applications

Carbon Fiber Biocompatibility for Implants

Inorganic fibers for biomedical engineering applications

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