Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode

El‐Desoky, Hanaa S.; Ghoneim, Enass M.; Ghoneim, Mohammed M.

doi:10.1016/j.jpba.2005.05.020

Cited by 23 publications

(8 citation statements)

References 26 publications

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“…Polarography is also used today in many control laboratories as a simple, commercially available, highly sensitive, and selective method for the determination of therapeutically active substances in medications and biological fluids; see for instance [27][28][29][30][31][32][33]. The main advantage of dropping mercury electrode (DME) against stationary electrodes is the high repeatability of measurements since each drop has a smooth and uncontaminated surface free from any adsorbed analyte or impurity.…”

Section: Introductionmentioning

confidence: 99%

A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

Plotycya

Strontsitska

Pysarevska

et al. 2018

International Journal of Electrochemistry

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A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored. It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1. The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively. In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed. The results of the analysis are in good agreement with the product specifications described in the quality certificates. The possibility of quantitative determination of benzocaine and procaine in pharmaceuticals is confirmed.

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Section: Introductionmentioning

confidence: 99%

A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

Plotycya

Strontsitska

Pysarevska

et al. 2018

International Journal of Electrochemistry

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“…Electrochemical methods of trimecaine and mepivacaine determination are not developed. At the same time many control laboratories still use polarography as a simple, commercially available, highly sensitive and selective method of therapeutically active substances determination in medications and biologic fluids, for instance . Local anesthetics are not reducible on Hg‐electrode, but their N‐oxides can be reduced.…”

Section: Introductionmentioning

confidence: 99%

Determination of Local Anesthetics of Amide Group in Pharmaceutical Preparations by Cyclic Voltammetry

et al. 2016

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A novel voltammetric method of local anesthetics such as lidocaine, trimecaine and mepivacaine determination has been developed. The proposed method was based on the obtaining of anesthetic N‐oxides in oxidation reaction with futher reduction of reaction product. Experimental conditions affecting quantitative yield of anesthetic N‐oxides such as oxidation time, oxidant concentration and temperature were studied. This assay was found to be linear (R=0.999) over a concentration range n⋅10−6–5 ⋅ 10−5 mol L−1. Calculated LOD and LOQ were found to be 0.38 and 1.14 μg mL−1 respectively. Sensitivity of presented method is comparable with that of chromatographic method. Overall, the developed method exhibited good selectivity towards components of pharmaceuticals and biological fluids. The proposed method was successfully applied to the analysis of studied anesthetics in different pharmaceutical samples.

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“…The proposed SWAdSV method was fully validated in terms of stability, linearity, sensitivity, precision, accuracy, recovery, selectivity, robustness, and ruggedness [27][28][29][30][31][32][33].…”

Section: Validation Of the Methodsmentioning

confidence: 99%

Square-wave adsorptive stripping voltammetric determination of candesartan cilexetil in pharmaceutical formulations

2009

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A sensitive, simple and rapid square-wave adsorptive stripping voltammetric method was developed and validated for the determination of candesartan cilexetil in pharmaceutical formulations. The proposed method was based on electrochemical reduction of candesartan cilexetil at a hanging mercury drop electrode in phosphate buffer at pH 5.0. A well-defined reduction peak was observed at -1340 mV with 30 s of accumulation time and -1100 mV of accumulation potential. Under these optimized conditions, the square-wave adsorptive stripping voltammetric peak current showed a linear correlation on drug concentration over the range of 0.25-1.34 lg mL -1 with a correlation coefficient of 0.9986 for the proposed method. The detection and quantitation limits for this method were 1 9 10 -2 and 2.5 9 10 -1 lg mL -1 , respectively. The results obtained for intra-day and inter-day precision (as RSD%) were between 1.10 and 3.90%. This method was applied successfully for the determination of candesartan cilexetil in its tablet dosage forms with mean recoveries of 101.13 ± 0.78% with RSD of 2.06% for 8 mg tablet and 99.84 ± 0.89% with RSD of 2.36% for 16 mg tablet. The results obtained from the developed square-wave adsorptive stripping voltammetric method were compared with those obtained by the analytical method reported in the literature.

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Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode

Cited by 23 publications

References 26 publications

A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

Determination of Local Anesthetics of Amide Group in Pharmaceutical Preparations by Cyclic Voltammetry

Square-wave adsorptive stripping voltammetric determination of candesartan cilexetil in pharmaceutical formulations

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