Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress

Reina, Simona; Nibali, Stefano Conti; Tomasello, Marianna Flora; Magrì, Andrea; Messina, Angela; Pinto, Vito De

doi:10.1016/j.redox.2022.102264

Cited by 29 publications

(33 citation statements)

References 68 publications

(101 reference statements)

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“…Vdac3 encodes the mammalian voltage-dependent anion-selective channel protein 3 of the outer mitochondrial membrane with a role in reactive oxygen species homeostasis. 34 Psat1 encodes phosphoserine aminotransferase 1 with a role in serine biosynthesis.…”

Section: Resultsmentioning

confidence: 99%

Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants

Chen

2023

iScience

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Section: Resultsmentioning

confidence: 99%

Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants

Chen

2023

iScience

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“…Cells were maintained as in (87), as was the monitoring of their proliferation. For cell treatments, 5-Aza-2’deoxycytidine (AzaD) was purchased from Sigma Chemical Co. (St. Louis, MO, USA) and resuspended in dimethyl sulfoxide (DMSO) at the concentration of 50 mg/mL, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Cells were maintained as in (87), as was the monitoring of their proliferation. For cell treatments, 5-Aza-2'deoxycytidine (AzaD) was purchased from Sigma Chemical Co. (St.…”

Section: Cell Cultures and Treatmentmentioning

confidence: 99%

HumanVDACpseudogenes: an emerging role forVDAC1P8pseudogene in acute myeloid leukemia

Pappalardo¹,

Risiglione²,

Zinghirino³

et al. 2023

Preprint

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Background. Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed. As 'mitochondrial gatekeepers', VDACs control organelle and cell metabolism and are involved in many diseases. Despite the presence of numerous VDAC pseudogenes in the human genome, their significance and possible role in VDAC protein expression has not yet been considered. Results. We investigated the relevance of processed pseudogenes of human VDAC genes, both in physiological and in pathological contexts. Using high-throughput tools and querying many genomic and transcriptomic databases, we show that some VDAC pseudogenes are transcribed in specific tissues and pathological contexts. The obtained experimental data confirm an association of the VDAC1P8 pseudogene with acute myeloid leukemia (AML). Conclusions. Our in-silico comparative analysis between the VDAC1 gene and its VDAC1P8 pseudogene, together with experimental data produced in AML cellular models, indicate a specific over-expression of the VDAC1P8 pseudogene in AML, correlated with a downregulation of the parental VDAC1 gene.

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“…Reina et al have proven that VDAC3 is a potential biomarker for mitochondria-related diseases [ 93 ]. Interestingly, a recent study has reported that VDAC3 is essential for resistance to ROS-induced oxidative stress [ 97 ]. During in vitro studies, it has been proven that knockdown of VDAC3 inhibits erastin-induced ferroptosis [ 98 ].…”

Section: Vdac3 and Pdmentioning

confidence: 99%

The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson’s Disease

Wang

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Parkinson’s disease (PD) is a neurodegenerative disease second only to Alzheimer’s disease in terms of prevalence. Previous studies have indicated that the occurrence and progression of PD are associated with mitochondrial dysfunction. Mitochondrial dysfunction is one of the most important causes for apoptosis of dopaminergic neurons. Therefore, maintaining the stability of mitochondrial functioning is a potential strategy in the treatment of PD. Voltage-dependent anion channel (VDAC) is the main component in the outer mitochondrial membrane, and it participates in a variety of biological processes. In this review, we focus on the potential roles of VDACs in the treatment of PD. We found that VDACs are involved in PD by regulating apoptosis, autophagy, and ferroptosis. VDAC1 oligomerization, VDACs ubiquitination, regulation of mitochondrial permeability transition pore (mPTP) by VDACs, and interaction between VDACs and α-synuclein (α-syn) are all promising methods for the treatment of PD. We proposed that inhibition of VDAC1 oligomerization and promotion of VDAC1 ubiquitination as an effective approach for the treatment of PD. Previous studies have proven that the expression of VDAC1 has a significant change in PD models. The expression levels of VDAC1 are decreased in the substantia nigra (SN) of patients suffering from PD compared with the control group consisting of normal individuals by using bioinformatics tools. VDAC2 is involved in PD mainly through the regulation of apoptosis. VDAC3 may have a similar function to VDAC1. It can be concluded that the functional roles of VDACs contribute to the therapeutic strategy of PD.

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Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress

Cited by 29 publications

References 68 publications

Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants

Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants

HumanVDACpseudogenes: an emerging role forVDAC1P8pseudogene in acute myeloid leukemia

The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson’s Disease

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