Voltage-dependent anion channel 2 (VDAC2) facilitates the accumulation of rice stripe virus in the vector Laodelphax striatellus

Lu, Zengjun; Li, Linying; Huang, Lijun; Xu, Chengzhu; Hu, Wei; Sun, Yixuan; Liu, Fang; Li, Yao

doi:10.1016/j.virusres.2022.199019

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…VDAC2 as a channel protein at the outer mitochondrial membrane 28 , in order to enhance the therapeutical effect of inhibition of VDAC2 malonylation, a new nano material, TPP-AAV(AAV(K46Q)@TPP-PEG@ODs), which could target mitochondria to inhibit VDAC2 malonylation was synthetized ( Figure 6 A ). TPP-COOH 1H NMR features are as δ 12.01 (s, 1H-COOH), 7.91-7.75 (m, 15H, Ar-H), 3.62-3.53 (m, 2H, -CH2-), 2.17-2.14 (m, 2H, -CH2-), 1.5 (s, 6H, -CH2-).…”

Section: Resultsmentioning

confidence: 99%

VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis

She,

Tan,

et al. 2023

Int. J. Biol. Sci.

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Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ dysfunction with elusive underlying mechanisms and limited treatment options. In this study, the cecal ligation and puncture and lipopolysaccharide (LPS) were used to reproduce sepsis model in vitro and vivo. The level of voltage-dependent anion channel 2 (VDAC2) malonylation and myocardial malonyl-CoA were detected by mass spectrometry and LC-MS-based metabolomics. Role of VDAC2 malonylation on cardiomyocytes ferroptosis and treatment effect of mitochondrial targeting nano material TPP-AAV were observed. The results showed that VDAC2 lysine malonylation was significantly elevated after sepsis. In addition, the regulation of VDAC2 lysine 46 (K46) malonylation by K46E and K46Q mutation affected mitochondrial-related ferroptosis and myocardial injury. The molecular dynamic simulation and circular dichroism further demonstrated that VDAC2 malonylation altered the N-terminus structure of the VDAC2 channel, causing mitochondrial dysfunction, increasing mitochondrial ROS levels, and leading to ferroptosis. Malonyl-CoA was identified as the primary inducer of VDAC2 malonylation. Furthermore, the inhibition of malonyl-CoA using ND-630 or ACC2 knock-down significantly reduced the malonylation of VDAC2, decreased the occurrence of ferroptosis in cardiomyocytes, and alleviated SIMD. The study also found that the inhibition of VDAC2 malonylation by synthesizing mitochondria targeting nano material TPP-AAV could further alleviate ferroptosis and myocardial dysfunction following sepsis. In summary, our findings indicated that VDAC2 malonylation plays a crucial role in SIMD and that targeting VDAC2 malonylation could be a potential treatment strategy for SIMD.

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Section: Resultsmentioning

confidence: 99%

VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis

She,

Tan,

et al. 2023

Int. J. Biol. Sci.

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“…Receptors 2024, 3, FOR PEER REVIEW 6 RNA-dependent RNA polymerase (RdRP). These interactions facilitated the accumulation of RSV in SBPH [31]. In silico analysis of interactions between glycoprotein of MMV and Syntaxin-18 (PmStx18) of corn planthopper (P. maidis) revealed PmStx18 as a putative receptor of MMV [32] (Figure 2).…”

Section: Thrips-associated Virus Receptorsmentioning

confidence: 99%

Deciphering the Role of Virus Receptors in Plant–Virus–Vector Interactions

Jangra,

Chinnaiah,

Patil

et al. 2024

Receptors

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Insect-transmitted plant viruses are a major threat to global agricultural crop production. Receptors play a prominent role in the interplay between host-pathogen and vector interaction. The virus–vector relationship involves both viral and vector receptors. Receptors-like kinases (RLKs) and receptor-like proteins play a crucial role in plant immunity, which acts as a basal defense. Pathogens can evade or block host recognition by their effector proteins to inhibit pathogen recognition receptor (PRR)-mediated signaling. Intriguingly, RLKs are also known to interact with viral proteins and impact plant susceptibility against viruses, while the endocytic receptors in vectors assist in the binding of the virus to the vectors. Unlike other receptors of fungi and bacteria which have three different domains located from extracellular or intracellular to perceive a multitude of molecular patterns, the characterization of viral receptors is quite complex and limited since the virus is directly injected into plant cells by insect vectors. Little is known about these receptors. Unraveling the receptors involved in virus entry and transmission within the vector will provide vital information in virus–vector interactions. This review focuses on efforts undertaken in the identification and characterization of receptors of plant viruses within the host and vector. This will lead to a better understanding of the cellular mechanism of virus transmission and spread, and further suggests new alternative tools for researchers to develop an integrated approach for the management of viral diseases and associated vectors.

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Voltage-dependent anion channel 2 (VDAC2) facilitates the accumulation of rice stripe virus in the vector Laodelphax striatellus

Cited by 2 publications

References 38 publications

VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis

VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis

Deciphering the Role of Virus Receptors in Plant–Virus–Vector Interactions

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