Voltage-based automated detection of postictal generalized electroencephalographic suppression: Algorithm development and validation

Hickman, L. Brian; Hogan, Robert; Labonte, Alyssa K.; Kafashan, MohammadMehdi; Chan, Courtney W.; Huels, Emma R.; Ching, ShiNung; Lenze, Eric J.; Maccotta, Luigi; Eisenman, Lawrence N.; Day, Brian K.; Farber, Nuri B.; Avidan, Michael S.; Palanca, Ben Julian A.

doi:10.1016/j.clinph.2020.08.015

Cited by 4 publications

(2 citation statements)

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“…EEG amplitude between Cz and suborbital facial electrodes (Cz-Face) is used to detect large amplitude CPCs. Green line shows seizure termination and onset of postictal generalized EEG suppression (PGES) ( 103 , 104 ). Topographic maps represent spatial topology of EEG voltage during phase 3 (red arrow) and PGES (blue arrow).…”

Section: Introductionmentioning

confidence: 99%

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

et al. 2022

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IntroductionElectroconvulsive therapy (ECT) is an effective intervention for patients with major depressive disorder (MDD). Despite longstanding use, the underlying mechanisms of ECT are unknown, and there are no objective prognostic biomarkers that are routinely used for ECT response. Two electroencephalographic (EEG) markers, sleep slow waves and sleep spindles, could address these needs. Both sleep microstructure EEG markers are associated with synaptic plasticity, implicated in memory consolidation, and have reduced expression in depressed individuals. We hypothesize that ECT alleviates depression through enhanced expression of sleep slow waves and sleep spindles, thereby facilitating synaptic reconfiguration in pathologic neural circuits.MethodsCorrelating ECT Response to EEG Markers (CET-REM) is a single-center, prospective, observational investigation. Wireless wearable headbands with dry EEG electrodes will be utilized for at-home unattended sleep studies to allow calculation of quantitative measures of sleep slow waves (EEG SWA, 0.5–4 Hz power) and sleep spindles (density in number/minute). High-density EEG data will be acquired during ECT to quantify seizure markers.DiscussionThis innovative study focuses on the longitudinal relationships of sleep microstructure and ECT seizure markers over the treatment course. We anticipate that the results from this study will improve our understanding of ECT.

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Section: Introductionmentioning

confidence: 99%

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

et al. 2022

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“… 20 , 27 , 30 Both in generalized spontaneous seizures and ECT‐induced seizures, stereotypical electroencephalographic (EEG) characteristics include ictal large amplitude rhythmic and hypersynchronous activity along with postictal suppression. 31 , 32 , 33 , 34 , 35 Ictal hyperperfusion of the brain and postictal hypoperfusion have been established in both epilepsy and ECT patients. 7 , 15 , 36 , 37 Investigating tonic‐clonic seizures is of increased value because clinical manifestation (ie, tonic and clonic phase), electroencephalographic characteristics (ie, generalized EEG spike‐wave complexes and postictal suppression), and neuroimaging findings (ie, ictal hyperperfusion and postictal hypoperfusion) are similar compared to ECT‐induced seizures.…”

Section: Introductionmentioning

confidence: 99%

Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study

et al. 2021

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Postictal generalized electroencephalographic suppression following electroconvulsive therapy: Temporal characteristics and impact of anesthetic regimen

Hickman

Kafashan

Labonte

et al. 2021

Clinical Neurophysiology

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Voltage-based automated detection of postictal generalized electroencephalographic suppression: Algorithm development and validation

Cited by 4 publications

References 30 publications

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

Seizures induced in electroconvulsive therapy as a human epilepsy model: A comparative case study

Postictal generalized electroencephalographic suppression following electroconvulsive therapy: Temporal characteristics and impact of anesthetic regimen

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