amplification, making them ideal candidates for miniaturized chemical and ion sensors that can be used for spatial mapping of analytes or multi-analyte sensing in space-limited applications. [9,10] However, in order to realize this, it is equally important to devise an addressing system that allows the output of each sensor to be measured while minimizing the number of signal lines leaving the sensor array. To accomplish this, we monolithically integrated indium gallium zinc oxide (IGZO) thin-film transistors (TFTs) and ionselective OECTs (IS-OECTs) on a flexible substrate to yield an array of ion-sensors addressed by a multiplexer (Figure 1). This system enables multiple sensors to be addressed and read out by low-cost measuring equipment, which opens the door to multi-analyte sensing and spatial mapping of analytes in applications ranging from environmental monitoring to biomedical research. The device architecture and principle of operation for the IS-OECTs used in this work are depicted in Figure 2a. The conductance of the OECT channel is dependent on the channel's oxidation state, which is in turn controlled through an ionically conductive medium by the application of a gate voltage from a reference electrode. [11][12][13][14] These devices are inherently sensitive to the total ion concentration, [15] and they can be made ion-selective by depositing an ISM on top of the channel. [6,7] As shown in Figure 2a, the ISM consisted of a salt of the ion of interest and an ionophore (depicted by stars) dissolved in a hydrophobic polymer membrane. The ionophore selectively solvates the cation of interest, and the anion is hydrophobic so it is soluble in the hydrophobic membrane and insoluble in the aqueous analyte. When the membrane is exposed to an analyte, some of the cations diffuse into the analyte because they are better solvated by water than by the ionophore. However, the hydrophobic anions are trapped in the membrane, leading to a phase-boundary potential between the membrane and the electrolyte. Since the fraction of ions that partition into the analyte is a function of the ion's concentration in the analyte, the membrane potential is also a function of the analyte concentration. Furthermore, since the ionophore selectively solvates the ion of interest, other ions do not diffuse into the membrane to any great extent, making the membrane potential predominantly a Organic electrochemical transistors (OECTs) are a promising class of devices for chemical and ionic sensing in aqueous media. Compared with conventional potentiometric techniques, OECT ion-sensors exhibit low output impedance that aids their miniaturization and integration in multi-sensor systems. However, in order to implement arrays of OECT sensors for multianalyte detection or spatial mapping of analytes, it is critical that the sensors be integrated with an addressing system that minimizes the number of signal lines leaving the sensor array. In this work, an integrated system comprising miniaturized ion-selective OECTs (IS-OECTs) that are addresse...