Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways

Hakim, Marwan; Broza, Yoav Y.; Barash, Orna; Peled, Nir; Phillips, Michael; Amann, Anton; Haick, Hossam

doi:10.1021/cr300174a

Cited by 705 publications

(760 citation statements)

References 137 publications

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“…Recently, the morbidity and death rate of lung cancer has been one of the most serious cancer, which greatly threaten the human's life and health [1]. According to the global statistics data released by International Agency for Research on Cancer of the World Health Organization [2], there were 14.1 million new cancer cases, 8.2 million cancer deaths, and 32.6 million people living with cancer (within 5 years of diagnosis) in 2012 worldwide.…”

Section: Introductionmentioning

confidence: 99%

Adsorption Properties of Typical Lung Cancer Breath Gases on Ni-SWCNTs through Density Functional Theory

Wan

Zhang

2017

Journal of Sensors

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A lot of useful information is contained in the human breath gases, which makes it an effective way to diagnose diseases by detecting the typical breath gases. This work investigated the adsorption of typical lung cancer breath gases: benzene, styrene, isoprene, and 1-hexene onto the surface of intrinsic and Ni-doped single wall carbon nanotubes through density functional theory. Calculation results show that the typical lung cancer breath gases adsorb on intrinsic single wall carbon nanotubes surface by weak physisorption. Besides, the density of states changes little before and after typical lung cancer breath gases adsorption. Compared with single wall carbon nanotubes adsorption, single Ni atom doping significantly improves its adsorption properties to typical lung cancer breath gases by decreasing adsorption distance and increasing adsorption energy and charge transfer. The density of states presents different degrees of variation during the typical lung cancer breath gases adsorption, resulting in the specific change of conductivity of gas sensing material. Based on the different adsorption properties of Ni-SWCNTs to typical lung cancer breath gases, it provides an effective way to build a portable noninvasive portable device used to evaluate and diagnose lung cancer at early stage in time.

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Section: Introductionmentioning

confidence: 99%

Adsorption Properties of Typical Lung Cancer Breath Gases on Ni-SWCNTs through Density Functional Theory

Wan

Zhang

2017

Journal of Sensors

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“…Much effort has been made in the past to link volatile organic compounds (VOCs) in exhaled air, to a patient's state of health [1], specifically with respect to identifying biomarkers for cancer [2][3][4][5][6]. Exhaled breath contains both gases, and aerosol droplets, however, the main focus of breath analysis thus far, has been on gas detection, which can contain: inorganic gases, i.e.…”

Section: Introductionmentioning

confidence: 99%

Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface

Pardon

Ladhani

Sandström

et al. 2015

Sensors and Actuators B: Chemical

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PostprintThis is the accepted version of a paper published in Sensors and actuators. B, Chemical. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the original published paper (version of record):Pardon, G., Ladhani, L., Sandström, N., Ettori, M., Lobov, G. et al. [Year unknown!] Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface. Sensors and actuators. B, Chemical AbstractIn this work, the development of a point-of-care (PoC) system to capture aerosol from litres of air directly onto a microfluidic lab-on-chip for subsequent analysis is addressed. The system involves an electrostatic precipitator that uses corona charging and electrophoretic transport to capture aerosol droplets onto a microfluidic air-to-liquid interface for downstream analysis. A theoretical study of the governing geometric and operational parameters for optimal electrostatic precipitation is presented. The fabrication of an electrostatic precipitator prototype and its experimental validation using a laboratory-generated aerosolized dye is described. Collection efficiencies were comparable to those of a state-of-the-art Biosampler impinger, with the significant advantage of providing samples that are at least 10 times more concentrated. Finally, we discuss the potential of such a system for breath-based diagnostics.

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“…Prolonged exposure to these pollutants can cause cancer, central nervous system damage, haematological problems, as well as sensitization involving the skin, eyes, and lungs. [1][2][3] Because of the importance of indoor air quality for the health and welfare of people, the utilization of highly efficient sensors for the detection and monitoring of VOCs became a crucial attempt. The currently available sensing approaches to detect VOCs mainly depend on the identification of output signals of optical, electrochemical, potentiometric, and quartz crystal microbalance (QCM) measurements.…”

Section: Introductionmentioning

confidence: 99%

VOC sensors based on a metal oxide nanofibrous membrane/QCM system prepared by electrospinning

et al. 2014

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aeWe report a simple synthetic route to fabricate crystalline ZnO and CeO 2 /ZnO nanofibrous mats and their sensing characteristics against volatile organic compounds (VOCs) such as benzene, propanol, ethanol, and dichloromethane. Precursor fibers were fabricated by electrospinning of poly(vinyl alcohol) and metal salt(s) at 2.5 kV cm À1 in aqueous solution. The fibers were directly deposited on the crystal surface of a quartz crystal microbalance (QCM). The crystal, which was coated by nanostructured PVA/metal precursor(s) fibers, was subjected to calcination in air at 500 1C for 5 h. The formation of an oxide based nanofiber mat was revealed by scanning electron microscopy and X-ray diffraction. Upon exposure of the nanofiber mats to the VOCs, the compounds adsorbed onto the surface of oxidic fibers. The physisorption of the compounds was confirmed by FTIR and QCM. Both systems showed sensitivity to the VOCs and they hold a broad promise particularly for sensing applications of volatile alcoholic compounds. The introduction of CeO 2 into the ZnO structure reduced the sensitivity of ZnO most probably due to the decrement of oxygen vacancies.

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Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways

Cited by 705 publications

References 137 publications

Adsorption Properties of Typical Lung Cancer Breath Gases on Ni-SWCNTs through Density Functional Theory

Adsorption Properties of Typical Lung Cancer Breath Gases on Ni-SWCNTs through Density Functional Theory

Aerosol sampling using an electrostatic precipitator integrated with a microfluidic interface

VOC sensors based on a metal oxide nanofibrous membrane/QCM system prepared by electrospinning

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