Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany

Beck, Jens; Heutelbeck, Astrid; Dunkelberg, H

doi:10.1016/j.scitotenv.2006.10.009

Cited by 20 publications

(17 citation statements)

References 60 publications

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“…The pollen contains a complex mixture of aliphatic and aromatic compounds that belong to the classes FAs (saturated, unsaturated, and dicarboxylic), aliphatic hydrocarbons (n-alkanes and n-alkenes), fatty alcohols, sterols, and terpenes. Some of these compounds have been identified previously in particulate matter (aerosols) [34], [35], [36]. Because of their critical role in pollen-stigma interactions during sexual reproduction, lipids are found in the outermost layer of the pollen extracellular matrix (coat) [37].…”

Section: Discussionmentioning

confidence: 99%

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

et al. 2013

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Background/AimPollen grains are the male gametophytes that deliver sperm cells to female gametophytes during sexual reproduction of higher plants. Pollen is a major source of aeroallergens and environmental antigens. The pollen coat harbors a plethora of lipids that are required for pollen hydration, germination, and penetration of the stigma by pollen tubes. In addition to proteins, pollen displays a wide array of lipids that interact with the human immune system. Prior searches for pollen allergens have focused on the identification of intracellular allergenic proteins, but have largely overlooked much of the extracellular pollen matrix, a region where the majority of lipid molecules reside. Lipid antigens have attracted attention for their potent immunoregulatory effects. By being in close proximity to allergenic proteins on the pollen surface when they interact with host cells, lipids could modify the antigenic properties of proteins.Methodology/Principal FindingsWe performed a comparative pollen lipid profiling of 22 commonly allergenic plant species by the use of gas chromatography-mass spectroscopy, followed by detailed data mining and statistical analysis. Three experiments compared pollen lipid profiles. We built a database library of the pollen lipids by matching acquired pollen-lipid mass spectra and retention times with the NIST/EPA/NIH mass-spectral library. We detected, identified, and relatively quantified more than 106 lipid molecular species including fatty acids, n-alkanes, fatty alcohols, and sterols. Pollen-derived lipids stimulation up-regulate cytokines expression of dendritic and natural killer T cells co-culture.Conclusions/SignificanceHere we report on a lipidomic analysis of pollen lipids that can serve as a database for identifying potential lipid antigens and/or novel candidate molecules involved in allergy. The database provides a resource that facilitates studies on the role of lipids in the immunopathogenesis of allergy. Pollen lipids vary greatly among allergenic species and contain many molecules that have stimulatory or regulatory effects on immune responses.

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Section: Discussionmentioning

confidence: 99%

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

et al. 2013

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“…Responses of the upper airway can be acute or chronic, as well as primary (sensory) or secondary (physiologic) (73)(74)(75). Nasal obstruction has been documented in response to a variety of agents, including acetic acid vapor, ammonia (76), chlorine (77,78), mixed volatile organic compounds (79) or cold air (80).…”

Section: Phenotype Of Narmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

167

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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“…We also did not consider papers in languages other than English [26], papers presenting data from ecologic studies [27,28], and papers that discussed exposures that are relevant to studies of proximity to traffic but measured in nontraffic settings (farm setting [29], indoor air [30][31][32][33]). We also excluded one paper that used doctors' house calls for asthma because this outcome does not represent populationbased asthma prevalence [34].…”

Section: Papers Not Consideredmentioning

confidence: 99%

Recent evidence for adverse effects of residential proximity to traffic sources on asthma

Salam

Islam

Gilliland

2008

Current Opinion in Pulmonary Medicine

158

117

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There is consistent evidence that living near traffic sources is associated with asthma occurrence and exacerbations. Future studies have the opportunity to improve exposure estimates by measuring traffic-related pollutants near homes and schools and including time/activity patterns in prediction models. Further research is also warranted to investigate the differential impact of traffic by genetic and other susceptibility factors and to identify specific pollutants that underlie the adverse effect of traffic on asthma.

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Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany

Cited by 20 publications

References 60 publications

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Recent evidence for adverse effects of residential proximity to traffic sources on asthma

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Volatile organic compounds in dwelling houses and stables of dairy and cattle farms in Northern Germany

Cited by 20 publications

References 60 publications

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

Pollen Lipidomics: Lipid Profiling Exposes a Notable Diversity in 22 Allergenic Pollen and Potential Biomarkers of the Allergic Immune Response

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Recent evidence for adverse effects of residential proximity to traffic sources on asthma

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Product

Resources

About

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper