Volatile organic compounds and risk of asthma and allergy: a systematic review and meta-analysis of observational and interventional studies

Nurmatov, Ulugbek; Tagieva, N.R. Tagieva; Semple, Sean; Devereux, Graham; Sheikh, Aziz

doi:10.4104/pcrj.2013.00010

Cited by 32 publications

(25 citation statements)

References 34 publications

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“…The incidence of asthma has been growing over the past several decades [ 1 , 2 ]. This increase coincides with changes to indoor environments [ 2 ], and some researchers have attributed the increase to changes in environmental influences [ 3 ]. Asthma is a growing public health concern because of its prevalence, significant health risks, and high healthcare costs [ 3 ].…”

Section: Introductionmentioning

confidence: 93%

Using Structural Equation Modeling to Assess the Links between Tobacco Smoke Exposure, Volatile Organic Compounds, and Respiratory Function for Adolescents Aged 6 to 18 in the United States

Shook-Sa

Chen

Zhou

2017

IJERPH

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Asthma is an inflammatory airway disease that affects 22 million Americans in the United States. Research has found associations between impaired respiratory function, including asthma and increased symptoms among asthmatics, and common indoor air pollutants, including tobacco smoke exposure and volatile organic compounds (VOCs). However, findings linking VOC exposure and asthma are inconsistent and studies are of mixed quality due to design limitations, challenges measuring VOC exposure, small sample sizes, and suboptimal statistical methodologies. Because of the correlation between tobacco smoke exposure and VOCs, and associations between both tobacco smoke and VOCs with respiratory function, it is crucial that statistical methodology employed to assess links between respiratory function and individual air pollutants control for these complex relationships. This research uses Structural Equation Modeling (SEM) to assess the relationships between respiratory function, tobacco smoke exposure, and VOC exposure among a nationally-representative sample of adolescents. SEM allows for multiple outcome variables, the inclusion of both observed and latent variables, and controls the effects of confounding and correlated variables, which is critically important and is lacking in earlier studies when estimating the effects of correlated air pollutants on respiratory function. We find evidence of associations between respiratory function and some types of VOCs, even when controlling for the effects of tobacco smoke exposure and additional covariates. Furthermore, we find that poverty has an indirect effect on respiratory function through its relationships with tobacco smoke exposure and some types of VOCs. This analysis demonstrates how SEM is a robust analytic tool for assessing associations between respiratory function and multiple exposures to pollutants.

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Section: Introductionmentioning

confidence: 93%

Using Structural Equation Modeling to Assess the Links between Tobacco Smoke Exposure, Volatile Organic Compounds, and Respiratory Function for Adolescents Aged 6 to 18 in the United States

Shook-Sa

Chen

Zhou

2017

IJERPH

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“…An electronic data extraction form applied in a previous study [ 28 ] will be modified and used (Additional file 3 ). Data to be extracted will include general study information (author name, title, source, country of origin, reviewer identification, study identification, and funding source), study characteristics (study design, population targeted, demographics, recruitment and follow-up rates, and so on), health outcome(s), exposures of interest, method of analysis ( a priori power calculation, statistical analysis, confounding factors, and subgroup analysis), and results.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of interventions to reduce indoor air pollution and/or improve health in homes using solid fuel in lower and middle income countries: protocol for a systematic review

et al. 2015

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BackgroundIndoor air pollution (IAP) interventions are widely promoted as a means of reducing indoor air pollution/health from solid fuel use; and research addressing impact of these interventions has increased substantially in the past two decades. It is timely and important to understand more about effectiveness of these interventions. We describe the protocol of a systematic review to (i) evaluate effectiveness of IAP interventions to improve indoor air quality and/or health in homes using solid fuel for cooking and/or heating in lower- and middle-income countries, (ii) identify the most effective intervention to improve indoor air quality and/or health, and (iii) identify future research needs.MethodsThis review will be conducted according to the National Institute for Health and Care Excellence (NICE) guidelines and will be reported following the PRISMA statement. Ovid MEDLINE, Ovid Embase, SCOPUS, and PubMed searches were conducted in September 2013 and updated in November 2014 (and include any further search updates in February 2015). Additional references will be located through searching the references cited by identified studies and through the World Health Organization Global database of household air pollution measurements. We will also search our own archives. Data extraction and risk of bias assessment of all included papers will be conducted independently by five reviewers.DiscussionThe study will provide insights into what interventions are most effective in reducing indoor air pollution and/or adverse health outcomes in homes using solid fuel for cooking or heating in lower- or middle-income countries. The findings from this review will be used to inform future IAP interventions and policy on poverty reduction and health improvement in poor communities who rely on biomass and solid fuels for cooking and heating.Systematic review registrationThe review has been registered with PROSPERO (registration number CRD42014009768).Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-015-0012-8) contains supplementary material, which is available to authorized users.

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“…In the European Community Respiratory Health Survey, asthma in children was positively associated with the presence of higher indoor concentration of the VOCs acetaldehyde and toluene (Hulin, Caillaud, & Annesi-Maesano, 2010). Several reviews have concluded there is insufficient research to evaluate the impact of VOCs on asthma control (Canova, Jarvis, Walker, & Cullinan, 2013;Institute of Medicine, 2000;Nurmatov, Tagieva, Semple, Devereux, & Sheikh, 2013;Tagiyeva & Sheikh, 2014). The impact of VOCs on asthma control and quality of life in older adults has not been explored.…”

Section: Chemical Emissions From Common Indoor Materials Are Associmentioning

confidence: 99%

Identifying phenotypes and factors impacting outcomes in older adults with asthma: A research protocol and recruitment results

Polivka

Folz

Myers

et al. 2018

Research in Nursing & Health

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Success in testing research outcomes requires identification of effective recruitment strategies in the targeted population. In this paper, we present the protocol for our NIH-funded study as well as success rates for the various recruitment strategies employed. This longitudinal observational study is: developing a phenotyping algorithm for asthma in older adults, exploring the effects of the asthma phenotype and of volatile organic compounds on asthma control, and developing a predictive model of asthma quality of life. A sub-aim is to characterize barriers to successful medication management in older adults with asthma. Individuals are eligible if they are ≥60 years, have a positive response to at least 1 of 6 asthma screening questions, non-smokers, and demonstrate bronchodilator reversibility or a positive bronchial challenge test with methacholine. Exclusion criteria are smokers who quit <5 years ago or with a >20 pack year smoking history, and those having other chronic pulmonary diseases. Participants (N=190) complete baseline pulmonary function testing, questionnaires, sputum induction, skin prick testing, and have blood drawn for Vitamin D and Immunoglobulin E. Home environmental assessments are completed including 24-hour particulate and volatile organic compound measurements. At 9-months post-baseline, home spirometry, medication assessment, and assessment of asthma quality of life and asthma control are assessed. At 18-months post-baseline, home spirometry, completion of baseline questionnaires, and a home environmental assessment are completed. We have employed multiple recruitment efforts including referrals from clinical offices, no-cost media events, flyers, and ads. The most successful efforts have been referrals from clinical offices and media events.

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Volatile organic compounds and risk of asthma and allergy: a systematic review and meta-analysis of observational and interventional studies

Cited by 32 publications

References 34 publications

Using Structural Equation Modeling to Assess the Links between Tobacco Smoke Exposure, Volatile Organic Compounds, and Respiratory Function for Adolescents Aged 6 to 18 in the United States

Using Structural Equation Modeling to Assess the Links between Tobacco Smoke Exposure, Volatile Organic Compounds, and Respiratory Function for Adolescents Aged 6 to 18 in the United States

Effectiveness of interventions to reduce indoor air pollution and/or improve health in homes using solid fuel in lower and middle income countries: protocol for a systematic review

Identifying phenotypes and factors impacting outcomes in older adults with asthma: A research protocol and recruitment results

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