Volatile Organic Compounds and Neurological Disorders: From Exposure to Preventive Interventions

Khan, Amjad; Kanwal, Hafsa; Bibi, Salma; Mushtaq, Saima; Khan, Arshad; Khan, Yusra Habib; Mallhi, Tauqeer Hussain

doi:10.1007/978-3-030-66376-6_10

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…[ 68 ] The continuous presence of human beings in an environment having VOCs for a prolonged period may cause cancer, especially lung cancer, liver and kidney damage, and central nervous system‐related problems. [ 69–71 ] Several investigators have also reported the presence of VOCs along with their side effects from incense smoke like Lofroth et al., [ 72 ] and Dewangan et al., 2013. [ 73 ] A team led by Dewangan studied the air quality of near‐religious and ritual areas to reveal the emission factors like VOCs, from Raipur City, India, and concluded that it contributes ≈23% of emission factors in the air from unknown sources.…”

Section: Major Harmful Components In Incense Smoke As An Air Pollutantmentioning

confidence: 99%

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

Yadav,

Bijekar,

Gacem

et al. 2023

Part & Part Syst Charact

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The drastic increase in industrialization has led to numerous adverse effects on the environment and human health. Respiratory tract disorders are one of the major emerging global health issues that lead to a high mortality rate every year. The quality of indoor and outdoor air has lowered in the last decade.The quality of indoor air has deteriorated by cooking, smoking, and burning incense sticks or smoke. The smoke released from incense and incense sticks contains gaseous products (carbon monoxide, nitrogen dioxide, and oxide of sulfur), particular matter (PM10, PM2.5), volatile organic compounds (VOCs), and polycyclic aromatic hydrocarbons (PAHs). These toxic components released from various incense sources pose a significant risk to human health and the environment. The inhalation and exposure of smoke from various incenses is hazardous to health as it inevitably culminates in deadly organ‐related diseases. With such insights, the present review article focuses on the characteristic attributes of particulate matter released from incense and other sources emphasizing healthcare and environmental concerns.

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Section: Major Harmful Components In Incense Smoke As An Air Pollutantmentioning

confidence: 99%

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

Yadav,

Bijekar,

Gacem

et al. 2023

Part & Part Syst Charact

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“…[76][77][78][79] Biomonitoring of urinary VOCs metabolites, due to its recent advances, has led to an accurate assessment the location of VOCs and the internal load of the body. New biomarkers for assessing airway inflammation, 34 lung damage, neurological disorders, 80 immune dysfunction, 7 and cancers, 81 in populations are made by VOC biomonitoring studies.…”

Section: Voc Biomonitoring Studies In Different Biological Samplesmentioning

confidence: 99%

An Overview on the Application of Solid Phase Microextraction in the Analysis of Volatile Organic Compounds as Potential Biomarkers of Cancer

Ayazi

Sarnaghi

2022

ImmunoAnalysis

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The search for biomarkers of diseases, especially for the early detection of cancer, is one of the most popular research fields in biomedicine. The development of non-invasive screening techniques for the early detection of cancer is one of the greatest scientific challenges of the 21st century. Because various diseases cause to generation of biomarkers in the body, early diagnosis of diseases can be performed by analyzing these biomarkers in all body feces. Detection of volatile organic compounds (VOCs) as biomarkers of the body's metabolic processes is a new frontier in the fast, sensitive, selective and non-invasive analysis and medical diagnosis of human diseases. VOCs as biomarkers in the human body can be distinct and specific to metabolic conditions or diseases. VOCs produced as end products of cellular metabolism and are released through a variety of biological matrices such as breath, blood, saliva, urine and feces. The study of volatile metabolites in the body fluids of the patients is performed to establish "potential biomarkers" for early diagnosis and prognosis of the disease. Various genetic, epigenetic, proteomic, and metabolic markers are evaluated for early detection of cancer. One of the promising emerging methods for early detection of cancer is the analysis of VOCs. The purpose of this review is to provide insights for recent research work on the analysis of VOC-biomarker of cancers with extraction by solid phase microextraction (SPME), and how to detect VOCs in different body matrices as a potential biomarker of disease.

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“…VOCs are molecules generated by cell metabolism that are released into the blood and can be detected directly in the circulation or via lungs, urine or skin [3]. In addition, these compounds can cross biological membranes, such as the bloodbrain-barrier [13]. They can be classified into five chemical functional groups: aldehydes, ketones, alcohols, hydrocarbons, and aromatic compounds [14,15].…”

Section: Introductionmentioning

confidence: 99%

Development of an organ-on-chip model for the detection of volatile organic compounds as potential biomarkers of tumour progression

Bayona,

Wrona,

Ranđelović

et al. 2024

Biofabrication

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Early detection of tumours remains a significant challenge due to their invasive nature and the limitations of current monitoring techniques. Liquid biopsies have emerged as a minimally invasive diagnostic approach, wherein volatile organic compounds (VOCs) show potential as compelling candidates. However, distinguishing tumour-specific VOCs is difficult due to the presence of gases from non-tumour tissues and environmental factors. Therefore, it is essential to develop preclinical models that accurately mimic the intricate tumour microenvironment to induce cellular metabolic changes and secretion of tumour-associated VOCs. In this study, a microfluidic device was used to recreate the ischaemic environment within solid tumours for the detection of tumour-derived VOCs. The system represents a significant advance in understanding the role of VOCs as biomarkers for early tumour detection and holds the potential to improve patient prognosis; particularly for inaccessible and rapidly progressing tumours such as glioblastoma.

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Volatile Organic Compounds and Neurological Disorders: From Exposure to Preventive Interventions

Cited by 8 publications

References 48 publications

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

An Overview on the Application of Solid Phase Microextraction in the Analysis of Volatile Organic Compounds as Potential Biomarkers of Cancer

Development of an organ-on-chip model for the detection of volatile organic compounds as potential biomarkers of tumour progression

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Volatile Organic Compounds and Neurological Disorders: From Exposure to Preventive Interventions

Cited by 8 publications

References 48 publications

The Impact of Fine Particulate Matters (PM10, PM2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

The Impact of Fine Particulate Matters (PM10, PM2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

An Overview on the Application of Solid Phase Microextraction in the Analysis of Volatile Organic Compounds as Potential Biomarkers of Cancer

Development of an organ-on-chip model for the detection of volatile organic compounds as potential biomarkers of tumour progression

Contact Info

Product

Resources

About

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer

The Impact of Fine Particulate Matters (PM₁₀, PM_2.5) from Incense Smokes on the Various Organ Systems: A Review of an Invisible Killer