Volatile organic compounds and good laboratory practices in the in vitro fertilization laboratory: the important parameters for successful outcome in extended culture

Abstract

None.

Clinical perspective: The perils, pitfalls and pride of developing an equine in vitro fertilisation (IVF) laboratory in private practice

“…The first room would be the ‘embryo room’ where the majority of IVF procedures would be performed, while the second room would be for processing of semen and storage of both frozen semen and embryos. Finally—and as will be discussed later—the location and dimensions (especially the height) of our laboratory created challenges in maintaining proper air quality, which can adversely affect embryonic development rates in IVF laboratories (Agarwal et al., 2017; Heitmann et al., 2015; Urman & Yakin, 2012).…”

“…Air particulates, micro‐organisms and volatile organic compounds (VOCs) are all substances that can hamper embryo development rates within an IVF laboratory. Several studies from human laboratories report a direct correlation between improved air quality and fertility, cleavage, blastocyst and pregnancy rates (Agarwal et al., 2017; Heitmann et al., 2015; Morbeck, 2019; Mortimer et al., 2018; Urman & Yakin, 2012). Evidence also exists regarding the significance of good air quality in equine ICSI laboratories, particularly as it relates to blastocyst rates (Herrera et al., 2023).…”

Effect of the Air Filtration System Replacement on Embryo Quality in the Assisted Reproduction Laboratory

“…Due to fluctuations in air quality, it is necessary to optimize a laboratory methodology to improve the results of IVF. 33 In the context of assisted reproduction techniques, air quality seems to have an impact mainly on follicular growth and embryogenesis. 34 Subsequent basic studies are needed to better understand the systemic and cellular pathways through which air contaminants affect cell division and reproduction viability.…”

“…Similarly, the Brazilian government has recently established a normative resolution that regulates the quality control for assisted reproduction centers (Resolution of the Collegiate Board of Directors [RDC, in the Portuguese acronym] no. 33 [RDC33], of February 17, 2006). 10 The main objectives of RDC33 are: to guarantee technical and quality standards throughout the process of obtaining, transporting, processing, storing, releasing, distributing, registering, and using germline cells and tissues for therapeutic purposes; to ensure the availability of germline cells and tissues from voluntary and anonymous donations for therapeutic purposes by third parties, or to maintain the reproductive capacity of the donor, with quality and safety; and to regulate the functioning of germline cell and tissue banks for reproductive therapeutic purposes.…”

Improving IUI success by performing modified slow-release insemination and a patient-centred approach in an insemination programme with partner semen: a prospective cohort study

“…Increasing implantation rates in IVF/ICSI programmes are the result of multiple improvements including on laboratory air quality ( Scorio et al, 2021 ), quality control ( Agarwal et al, 2017 ) and the overcoming of technical challenges of embryo(s) selection and transfer by use of state-of-the-art close incubation systems, ultrasound guidance and soft catheters ( Mains and Van Voorhis, 2010 ).…”