“…In most cases, the effect would be negligibly small, but in some cases, especially for nanodevices operating under ambient conditions, this could be pivotal in running them under optimal conditions. [1][2][3][4][5][6][7][8] Unfortunately, no device is yet available to measure the effect directly, but we reported recently that the VOC effect, at least on nanostructured gold and silver, can be identified, although indirectly, by means of surface-enhanced Raman scattering (SERS) of isocyanides. [9][10][11] For instance, in the presence of acetone the NC stretching band of 2,6-dimethylphenylisocyanide (2,6-DMPI) on Au blue-shifted by as much as 6 cm À1 , while the same band red-shifted by as much as 20 cm À1 in the presence of ammonia.…”