Volatile oil constituents and antibacterial activity of different parts of<i>Falcaria vulgaris</i>Bernh. growing wild in two localities from Iran

Shafaghat, Ali

doi:10.1080/14786411003774312

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…Thus, compounds with antioxidant activity can ameliorate these changes and prevent the progression of nephropathy [52]. F. vulgaris as a medicinal plant rich in antiinflammatory and antioxidant compounds such as spathulenol, carvacrol, alpha-pinene and limonene, and it has strong antiinflammatory and antioxidant properties [20,53,54]. Previous studies have indicated that ethnomedicinal plants rich in antiinflammatory and antioxidant compounds decrease weight, volumes and lengths of kidney and its subcomponents in STZ-induced nephrotoxicity in mice [55,56].…”

Section: Nephroprotective Effect Of F Vulgarismentioning

confidence: 99%

Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Zangeneh

Tahvilian

et al. 2018

Arch biol sci (Beogr)

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Falcaria vulgaris has been used in medicine as an antimicrobial agent. The aims of this study were to evaluate the hypoglycemic and nephroprotective activities of the aqueous extract of F. vulgaris in diabetic mice. Diabetes was experimentally induced by intraperitoneal injection of streptozotocin (STZ). The mice were divided randomly into 6 groups as follows: nondiabetic, untreated diabetic, a group that received orally 0.5 mg/kg glibenclamide, and three groups that were given orally 200, 600 and 1800 µg/kg of F. vulgaris, respectively, for 20 days. On the 20 th day, the mice were dissected, and blood and kidney samples were collected for analysis of hematological, biochemical and stereological parameters. F. vulgaris at all doses, particularly 1800 µg/kg, significantly (p≤0.05) reduced the levels of urea, creatinine, WBC, eosinophils, basophiles, platelet and increased RBC, Hb, PCV, MCV, MCH, MCHC, lymphocytes and monocytes that were raised after diabetes induction, compared to the untreated diabetic group. Multiple doses of F. vulgaris, particularly1800 µg/kg, significantly (p≤0.05) decreased the total volumes of the kidney cortex, medulla, vessels and renal tubules, as well as the lengths of the vessels and renal tubules, compared to the untreated diabetic group. Also, F. vulgaris at all doses significantly prevented glomerular hypertrophy and reduction of glomeruli numbers in comparison with the untreated diabetic group. In conclusion, F. vulgaris possesses antidiabetic, hematoprotective and nephroprotective properties and can improve renal structural and blood biomarkers in STZ-induced nephrotoxicity in mice.

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Section: Nephroprotective Effect Of F Vulgarismentioning

confidence: 99%

Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Zangeneh

Tahvilian

et al. 2018

Arch biol sci (Beogr)

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“…Phytochemical analysis showed that the major components of F. vulgarisʼs volatile oil belong to sesqui-and mono-terpene groups of chemicals. 17,18 In I. tataricum Pallas (Ixioliriaceae), the dominant components were found to be 2-phenylethyl phenylacetate, β-selinene, bicyclovetivenol, thymol, and chalcone. 19 A broad spectrum of physiological and medicinal properties were attributed to the species of this family including the following: anti-inflammatory (Liu et al, 2015), acetylcholinesterase inhibitory, 20 immunostimulatory, and DNAbinding activities.…”

Section: Introductionmentioning

confidence: 99%

“…is a member of Apiaceae family with distinct biological antiaging activities among others, such as antioxidant, skin healing, antidiabetic, hepato‐ and hemato‐protective properties and many other pharmacological effects. Phytochemical analysis showed that the major components of F. vulgaris 's volatile oil belong to sesqui‐ and mono‐terpene groups of chemicals …”

Section: Introductionmentioning

confidence: 99%

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Momtaz

Baeeri

Rahimifard

et al. 2018

J of Cellular Biochemistry

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Aging contributes to an increased risk of developing a number of neurodegenerative and chronic disorders, predominantly related to oxidative stress (OS) and defects in the antioxidant balance. This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, and Scabiosa flavida) on H2O2‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The levels of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evaluated by flow cytometry. The expression of senescence‐related inflammatory cytokines and the molecules involved in aging signaling pathways were investigated using the real‐time reverse transcription polymerase chain reaction (RT‐PCR). H2O2 treatment decreased cell viability and increased lipid peroxidation (LPO) and the reactive oxygen species (ROS) in NIH3T3s. However, S. flavida exhibited low cytotoxicity, reduced OS and SA‐ß‐GAL activities in NIH3T3 cells compared with the H2O2‐treated group. I. tataricum was the second best plant, although it was more toxic to NIHT3T cells. S. flavida decreased G0/G1 arrest and facilitated the G2/M transition of NIH3T3s, also downregulated the expression of p38, p53, p16, and the related inflammatory mediators. S. flavida potentially modulated senescence‐associated hallmarks in fibroblasts exposed to H2O2, thus it may inhibit the aging process via controlling the OS. Therefore it is a promising candidate for future antiaging explorations.

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“…Despite the use of preservatives to control microorganisms that cause food spoilage and infection, food safety is an important challenge in the industry. Currently, the use of natural preservatives is a healthy and effective alternative to chemicals (Shafaghat, 2011). Evaluation of antibacterial activity is necessary to determine the activity of edible lm against bacterial pathogens for different applications.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Fabrication and characterization of cellulose acetate film containing Falcaria vulgaris extract

et al. 2023

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Nowadays, the use of packaging materials based on natural polymers reduces the use of synthetic materials that cause environmental pollution. For this reason, in the present study, the possibility of preparing biodegradable lms from cellulose acetate incorporated with Falcaria vulgaris extract was investigated. Cellulose acetate lms were produced by casting method and Falcaria vulgaris extract was added in concentrations of 0.1, 0.2 and 0.3%. Mechanical properties, permeability to water vapor and oxygen, solubility, color, opacity, contact angle, morphology, antioxidant and antimicrobial properties of cellulose acetate lms were evaluated. The results showed that the tensile strength, modulus of elasticity, vapor permeability, water absorption, solubility, swelling percentage and percentage of water content of the resulting lms decreased with the increase of Falcaria vulgaris extract concentration. The contact angle percentage of cellulose acetate lm and cellulose acetate lm with 0.3% extract were 59.32 ± 0.97, 65.47 ± 1.16, respectively. Cellulose acetate lms containing Falcaria vulgaris extract showed good antioxidant properties, namely the amount of DPPH radical trapping of cellulose acetate lm with 0.3% extract equals 35.31% compared to cellulose acetate lm (0.15%), which showed a signi cant increase.Furthermore, the produced lms showed good antimicrobial properties against Escherichia coli, Staphylococcus aureus, Candida albicans and Candida glabrata. In general, this study showed that cellulose acetate lm containing extract could be used for food packaging that increasing the shelf life of food.

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Volatile oil constituents and antibacterial activity of different parts ofFalcaria vulgarisBernh. growing wild in two localities from Iran

Cited by 15 publications

References 5 publications

Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells

Fabrication and characterization of cellulose acetate film containing Falcaria vulgaris extract

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