Volatile fluorinated nanoemulsions: A chemical route to controlled delivery of inhalation Anesthesia

Salama, Ibrahim E.; Jenkins, Claire L.; Davies, A. Matthew; Clark, J. R.; Wilkes, A. R.; Hall, Judith Elizabeth; Paul, Alison

doi:10.1016/j.jcis.2014.10.021

Cited by 4 publications

(4 citation statements)

References 20 publications

(33 reference statements)

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“…S2), consistent with the proposed evaporation mechanism [8]. By altering stirring rate, the output of the anaesthetic delivery device can be made to vary in a responsive and predictable manner (Fig.…”

Section: Resultssupporting

confidence: 76%

“…At a fixed gas flow rate and constant stirring rate, the level of anaesthetic release from a given formulation drops gradually over time as the amount of sevoflurane remaining in the formulation decreases ( Fig. S2), consistent with the proposed evaporation mechanism [8]. By altering stirring rate, the output of the anaesthetic delivery device can be made to vary in a responsive and predictable manner ( Fig.…”

Section: Resultssupporting

confidence: 70%

“…It is also worth noting that a single formulation was used to obtain release at the full range of gas flows and target concentrations studied. This represents an improvement on formulations identified previously, where different formulations were used for individual target concentrations [8].…”

Section: Resultsmentioning

confidence: 99%

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Laboratory evaluation of a novel anaesthesia delivery device

et al. 2016

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SummaryHere, we describe proof of concept of a novel method for delivering volatile anaesthetics, where the liquid anaesthetic (sevoflurane or isoflurane) is formulated into an emulsion that is contained in a compact, lightweight device through which carrier gas flows. Release of anaesthetic is achieved by stirring of the formulation, allowing controlled and responsive release of anaesthetic at a variety of fixed flow rates between 0.5 l.min À1 and 5 l.min À1, with ventilated, non-ventilated and draw-over breathing systems. Anaesthetic release was evaluated using target anaesthetic concentrations ranging from 0.5% v/v to 8% v/v to mimic those typically required for induction and maintenance of anaesthesia, and lower concentrations suitable for sedation. Under all conditions, output could be maintained within 0.1% v/v of the intended setting, and the device could deliver a controlled level of anaesthetic for at least 60 min, with compensation for different ambient temperatures (10-30°C) and carrier gas flow rates. This device offers a simple, inexpensive method of delivering safe concentrations of volatile anaesthetics for a wide range of applications.

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Section: Resultssupporting

confidence: 76%

Section: Resultssupporting

confidence: 70%

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Laboratory evaluation of a novel anaesthesia delivery device

et al. 2016

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“…Although there are currently not many clinical applications of nanotechnology in inhalation drug delivery, establishing a novel drug administration route using lung inhalation nanoparticles could allow for an innovative approach. Salama et al [ 44 ] formulated novel dispersions for the volatile inhalation of the anesthetic sevoflurane with a diameter of 250 nm. They customized the flow device to provide controlled, sustained, and adjustable release of the anesthetic across a clinically usable time frame.…”

Section: Application Of Nanotechnology In the Anesthesia Fieldmentioning

confidence: 99%

Application of Advanced Technologies—Nanotechnology, Genomics Technology, and 3D Printing Technology—In Precision Anesthesia: A Comprehensive Narrative Review

Gu,

Luo,

Wen

et al. 2023

Pharmaceutics

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There has been increasing interest and rapid developments in precision medicine, which is a new medical concept and model based on individualized medicine with the joint application of genomics, bioinformatics engineering, and big data science. By applying numerous emerging medical frontier technologies, precision medicine could allow individualized and precise treatment for specific diseases and patients. This article reviews the application and progress of advanced technologies in the anesthesiology field, in which nanotechnology and genomics can provide more personalized anesthesia protocols, while 3D printing can yield more patient-friendly anesthesia supplies and technical training materials to improve the accuracy and efficiency of decision-making in anesthesiology. The objective of this manuscript is to analyze the recent scientific evidence on the application of nanotechnology in anesthesiology. It specifically focuses on nanomedicine, precision medicine, and clinical anesthesia. In addition, it also includes genomics and 3D printing. By studying the current research and advancements in these advanced technologies, this review aims to provide a deeper understanding of the potential impact of these advanced technologies on improving anesthesia techniques, personalized pain management, and advancing precision medicine in the field of anesthesia.

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Adsorption model and phase transitions of diblock perfluoroalkylated surfactants at the water∣alkane interface

Peychev

Slavchov

2021

Journal of Colloid and Interface Science

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Volatile fluorinated nanoemulsions: A chemical route to controlled delivery of inhalation Anesthesia

Cited by 4 publications

References 20 publications

Laboratory evaluation of a novel anaesthesia delivery device

Laboratory evaluation of a novel anaesthesia delivery device

Application of Advanced Technologies—Nanotechnology, Genomics Technology, and 3D Printing Technology—In Precision Anesthesia: A Comprehensive Narrative Review

Adsorption model and phase transitions of diblock perfluoroalkylated surfactants at the water∣alkane interface

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