Volatile constituents of wild and in vitro cultivated Gloeophyllum odoratum

Kahlos, K.; Kiviranta, J.; Hiltunen, R.

doi:10.1016/s0031-9422(00)90463-1

Cited by 26 publications

(5 citation statements)

References 20 publications

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“…For example, Larsen and Frisvad [58] found that while volatile profiles from Penicillium isolates were generally similar when the isolates were grown on either yeast extract sucrose agar or malt extract agar, fewer VOCs were produced by the same isolates when grown on Czapek yeast autolysate agar. Kahlos et al [59] found that VOCs produced by the brown rot fungus Gloeophyllum odoratum varied, depending on the presence in the media of different growth elicitors, indicating the importance of media in studies of this nature. Hence, precedence exists for expecting MVOC variability due to growth media.…”

Section: Effect Of the Growth Substrates On Mvocs' Productionmentioning

confidence: 99%

Effects of Growth Parameters on the Analysis of Aspergillus flavus Volatile Metabolites

et al. 2016

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Aspergillus flavus produces dangerous secondary metabolites known as aflatoxins, which are toxic and carcinogenic, and their contamination of agricultural products results in health issues and economic hardships in the U.S. and around the world. Early identification of aflatoxigenic isolates of A. flavus is the key in the management of these fungi. An emerging detection method for specific fungi identification involves the analysis of microbial volatile organic compounds (MVOCs) released by the fungi. Complicating this approach is the understanding that many factors influence metabolic production, including growth parameters, such as growth media, temperature, spore counts and oxidation stress. In addition, analytical and data analysis methods can also influence the results. Several growth and analysis methods were evaluated and optimized in order to better understand the effect of the methods on fungi MVOC signatures. The results indicate that carboxen/polydimethylsiloxane (CAR/PDMS) has the best extraction efficiency for the MVOCs emitted by A. flavus. Both chemical defined agar (CDA) and chemical defined liquid (CDL) are suitable growth media for MVOC emission studies. The highest MVOC production was found at 30˝C. Log transformation was considered one of the best data pretreatment methods when analyzing MVOC data and resulted in the best principal component analysis (PCA) clustering in the experiments with different growth media. This study aims to elucidate fungal volatile organic compounds (VOCs) differences due to variations in growth parameters as a first step in the development of an analytical method for the monitoring of aflatoxigenic A. flavus contamination in crop storage facilities.

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Section: Effect Of the Growth Substrates On Mvocs' Productionmentioning

confidence: 99%

Effects of Growth Parameters on the Analysis of Aspergillus flavus Volatile Metabolites

et al. 2016

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“…In an effort to elucidate its metabolic fate in humans, micro‐organisms are also recently utilized as in vitro systems to predict and prepare the potential mammalian metabolites of betulinic acid (Cichewicz and Kouzi 2004). Betulin was transformed by the brown‐rot fungus Gloeophyllum odoratum (Kahlos et al. 1994).…”

Section: Introductionmentioning

confidence: 99%

Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells

Liu

Chen

2010

Journal of Applied Microbiology

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Aims: Betulinic acid has attracted attention in terms of its important biological and pharmacological characteristics. The main objective of this work was to optimize the variables of biotransformation process in order to enhance betulinic acid production from betulin catalysed by fungus Armillaria luteo‐virens Sacc ZJUQH100‐6. Methods and Results: Fractional factorial design and response surface methodology were applied to optimize the main parameters that affect betulinic acid production in the growing‐cells system. Results indicated that the addition of Tween 80 and substrate concentration were identified as the significant factors on betulinic acid formation, and the central composite experimental design was then adopted to derive a statistical model for optimizing biotransformation conditions. The optimum conditions were observed at pH 6·0, 0·57% Tween 80, 15 mg l−1 betulin and at 3 days of stage of inoculation. Conclusions: Under the optimized conditions, the highest productivity of betulinic acid predicted was 9·32%, which increased by 74·53% in comparison with that of the nonoptimized. The verified experiment revealed that the model can well simulate betulin biotransformation. Moreover, the bioconversion of betulin and betulin‐28‐monooxygenase activities was compared between the optimized and the nonoptimized conditions. Significance and Impact of the Study: Current data imply that betulinic acid production from betulin can be effectively enhanced through biotransformation optimization strategy.

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“…70 Wood-rotting Basidiomycetes like Gloeophyllum odoratum and Laricifomes officinalis also produce drimanes. [71][72][73][74] Peniophora polygonia, which demonstrates a distinct antagonism against Phellinus tremulae, afforded several new active drimane sesquiterpenoids. 75 With oceans covering a sizeable percentage of the earth, the potential of marine biodiversity has attracted many investigators and several biologically active drimane metabolites have been isolated.…”

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confidence: 99%

Occurrence, biological activity and synthesis of drimane sesquiterpenoids

2004

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In this review the names, structures and occurrence of all new drimanes and rearranged drimanes which have been published between January 1990 and January 2003 have been collected. Subjects that have been treated are biosynthesis, analysis, biological activities, with special attention to cytotoxic activity and antifeedant and insecticidal activity and mode of action. An important part of the review deals with the synthesis of drimanes. This part has been subdivided into syntheses by transformation of natural products, syntheses starting from chiral compounds obtained by enzymatic resolution, syntheses by cationic polyolefin cyclizations, syntheses from trans-decalones, syntheses by radical cyclizations and syntheses by cycloaddition reactions. The review contains about 350 references.

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Volatile constituents of wild and in vitro cultivated Gloeophyllum odoratum

Cited by 26 publications

References 20 publications

Effects of Growth Parameters on the Analysis of Aspergillus flavus Volatile Metabolites

Effects of Growth Parameters on the Analysis of Aspergillus flavus Volatile Metabolites

Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells

Occurrence, biological activity and synthesis of drimane sesquiterpenoids

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