Volatile Constituents of <i>Zanthoxylum rhetsa</i> Leaves and Seeds

Shafi, P. M.; Saidutty, A.; Clery, Robin A.

doi:10.1080/10412905.2000.9699492

Cited by 21 publications

(10 citation statements)

References 3 publications

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“…The fruits of the plant were collected from the central part of Bangladesh in the month of July. The major bioactive constituents of volatile oil obtained from Zanthoxylum rhetsa dried fruit are Terpinen-4-ol, α-limonene, β-phellandrene and (+)-sabinene [58].…”

Section: Zanthoxylum Rhetsa Seed Oil (Zro) Seed Collectionmentioning

confidence: 99%

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

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Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. Methods: The self-emulsifying properties of apricot, avocado, black seed and Zanthoxylum rhetsa seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl® and Neusilin® at 1:1 w/w ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS. Results: The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.

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Section: Zanthoxylum Rhetsa Seed Oil (Zro) Seed Collectionmentioning

confidence: 99%

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

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“…The compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) and antibiotics (amoxicillin and fluconazole) were dissolved in DMSO, followed by dilution with peptone water to obtain the desired concentration (200 µg/mL for antibiotic and 400 µg/mL for compounds).…”

Section: Preparation Of Samples and Standardsmentioning

confidence: 99%

“…The oil is effective in cholera and as an antiseptic, disinfectant and antiinflammatory agent [2,3]. Previous phytochemical investigation of this plant revealed the presence of quinoline and indopyridoquinazoline alkaloids [4,5], phytosterol and flavanone [6], volatile oils and terpenes [7]. As part of our research project focusing on Bangladeshi medicinal plants [8][9][10], we here report the antimicrobial activities of alkaloids (2)(3)(4)(5)(6)(7)(8)(9) and lignans (1 and 10) from the stem bark of Z. budrunga against both Gram positive and Gram negative bacteria and fungi.…”

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confidence: 99%

Antimicrobial Activities of Alkaloids and Lignans from Zanthoxylum budrunga

Rahman

Gray

Khondkar

et al. 2008

Natural Product Communications

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Eight alkaloids (2-9) and two lignans (1 and 10) isolated from the stem bark of Zanthoxylum budrunga were tested against a panel of bacteria (both Gram positive and Gram negative) and fungi. Significant antibacterial activities were exhibited by all compounds against the test bacterial strains, except Klebsiella aerogenes. All compounds except the mixture of 2 and 3 showed reasonable antifungal activity against Aspergillus niger and Candida albicans. The MICs of the compounds against the test organisms were recorded in the range of 0.06-1.568 µmol.

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“…Z. rhetsa activity is a mosquito repellent, and its larvicidal, antimicrobial, antioxidant, and antitumor activities have been characterized [20]. Additionally, major chemical compounds in pericarp, fruit, and seed of Z. rhetsa as monoterpenes such as limonene, terpinen-4-ol, sabinene, and α-pinene [21][22][23][24][25][26][27][28][29][30] have been reported for their anti-inflammatory activity [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Investigations of Extracts of Zanthoxylum rhetsa

Imphat

Thongdeeying

Itharat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Zanthoxylum rhetsa has been consumed in the diet in northern Thailand and also used as a medicament in ancient scripture for arthropathies. Thus, this study aimed to evaluate the activity of various extracts from differential parts of Z. rhetsa via inhibition of inflammatory mediators (NO, TNF-α, and PGE2) in RAW264.7 macrophages. The chemical composition in active extracts was also analyzed by GC/MS. The parts of this plant studied were whole fruits (F), pericarp (P), and seed (O). The methods of extraction included maceration in hexane, 95% ethanol and 50% ethanol, boiling in water, and water distillation. The results demonstrated that the hexane and 95% ethanolic extract from pericarp (PH and P95) and seed essential oil (SO) were the most active extracts. PH and P95 gave the highest inhibition of NO production with IC50 as 11.99 ± 1.66 μg/ml and 15.33 ± 1.05 μg/ml, respectively, and they also showed the highest anti-inflammatory effect on TNF-α with IC50 as 36.08 ± 0.55 μg/ml and 34.90 ± 2.58 μg/ml, respectively. PH and P95 also showed the highest inhibitory effect on PGE2 but less than SO with IC50 as 13.72 ± 0.81 μg/ml, 12.26 ± 0.71 μg/ml, and 8.61 ± 2.23 μg/ml, respectively. 2,3-Pinanediol was the major anti-inflammatory compound analyzed in PH (11.28%) and P95 (19.82%) while terpinen-4-ol constituted a major anti-inflammatory compound in SO at 35.13%. These findings are the first supportive data for ethnomedical use for analgesic and anti-inflammatory activity in acute (SO) and chronic (PH and P95) inflammation.

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Volatile Constituents of Zanthoxylum rhetsa Leaves and Seeds

Cited by 21 publications

References 3 publications

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Antimicrobial Activities of Alkaloids and Lignans from Zanthoxylum budrunga

Anti-Inflammatory Investigations of Extracts of Zanthoxylum rhetsa

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