Volatile compounds and biological activities of aerial parts of &lt;i&gt;Pituranthos scoparius&lt;/i&gt; (Coss and Dur) Schinz (Apiaceae) from Hoggar, southern Algeria

Ksouri, Aicha; Dob, Tahar; Belkebir, Aicha; Dahmane, Dahmane; Nouasri, Ahmed

doi:10.4314/tjpr.v16i1.7

Cited by 14 publications

(17 citation statements)

References 14 publications

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“…3-butylidene-7-hydroxyphthalide identified from conditioned media HSG16 has previously reported anticancer activity; it exhibited cytotoxicity against breast cancer MCF-7 cells [ 35 ]. While these identified molecules had reported anticancer activity, the other detected molecules had a broad range of reported biological activities: citric acid, dextromethorphan and 3-butylidene-7-hydroxyphthalide had reported antibacterial activity [ 36 , 37 , 38 , 39 , 40 ]. U-0126, 3-hydroxymorphinan and bifemelane exhibited neuroprotective effects [ 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules

Soopramanien

Khan

Ghimire

et al. 2020

Biology

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Despite intensive research, cancer incidence and mortality continue to rise. Consequently, the necessity to develop effective anti-cancer therapy is apparent. We have recently shown that the gut bacteria of animals living in polluted environments, such as crocodiles, are a potential source of novel anti-tumor molecules. To extend this work to other resilient species, we investigated the anti-tumor effects of gut bacteria of Heterometrus spinifer (a scorpion). Bacteria from the feces and gut were isolated, identified and evaluated for their anti-tumor effects. Bacterial-conditioned media was prepared in Roswell Park Memorial Institute (RPMI) 1640 media, and cytotoxicity and growth inhibitory properties were examined against cervical (HeLa) cancer cells. Liquid chromatography–mass spectrometry (LC-MS) was conducted to establish the identity of the molecules. Eighteen bacteria species from the gut (HSG01-18) and ten bacteria species from feces (HSF01-10) were tested for anti-tumor effects. Bacterial-conditioned media from scorpion gut and feces exhibited significant growth inhibitory effects against HeLa cells of 66.9% and 83.8%, respectively. Microscopic analysis of cancer cells treated with conditioned media HSG12 and HSG16 revealed apoptosis-like effects. HSG12 was identified as Pseudomonas aeruginosa and HSG16 was identified as Bacillus subtilis. Both conditioned media exhibited 100% growth inhibitory effects versus a selection of cancer cells, comprising cervical, breast and prostate cancer cells. LC–MS indicated the presence of 72 and 38 compounds, detected from HSG12 and HSG16, respectively. Out of these compounds, 47 were successfully identified while the remainder were unidentified and are possibly novel. This study suggests that the fecal and gut microbiota of scorpions might possess molecules with anti-cancer properties, however, further intensive research is needed to assess these expectations.

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Section: Discussionmentioning

confidence: 99%

Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules

Soopramanien

Khan

Ghimire

et al. 2020

Biology

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“…This plant known commonly as ‘Guezzah’ or ‘Tattai’ and classified in four deferent species called, P. scoparius , P. chloranthus , P. battandieri and P. reboudii ; this plant distributed regularly in rocky pastures of north Africa and in most parts of the Sahara regions . The choice of our examined plant was based on two criteria: first, in phenolic compounds filed there are few researchers in Algeria that dealt with this plant, and the second is that this plant has been used widely in Algerian folk‐medicine to cure common diseases such as hepatitis, postpartum care, urinary infections, diabetes, fevers, pains, digestive difficulties, spasms and scorpion tings …”

Section: Introductionmentioning

confidence: 99%

“…[7] The choice of our examined plant was based on two criteria: first, in phenolic compounds filed there are few researchers in Algeria that dealt with this plant, and the second is that this plant has been used widely in Algerian folk-medicine to cure common diseases such as hepatitis, postpartum care, urinary infections, diabetes, fevers, pains, digestive difficulties, spasms and scorpion tings. [8] Several studies indicate that plant tissues phenolic profiles in general, affected by numerous factors such as environment, genotype, time of harvesting, growth stage, storage conditions and method of analysis. [9] Hence, the present study aimed to evaluate the fluctuations of TPC, FC and CTC in D. scoparia (flowers/ seeds) plant harvested from different places during two seasons (2016 and 2017), also evaluate their in vitro antioxidant potentials using several tests as they are useful to evaluate the bioactive compounds antioxidant potential.…”

Section: Introductionmentioning

confidence: 99%

Effect of Seasonal and Regional Variations on Phenolic Compounds of Deverra scoparia (Flowers/Seeds) Methanolic Extract and the Evaluation of Its in Vitro Antioxidant Activity

Benarfa

Gourine

Mahfoudi

et al. 2019

Chemistry & Biodiversity

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The widespread use of Deverra scoparia Coss. & Durieu in Algerian folk‐medicine as a remedy can be relatively attributed to its total phenolic compounds. The current study aimed to provide a scientific basis for optimal collection and usage of Deverra scoparia Coss. & Durieu plant. Hence, 37 samples were gathered from nine sites in Algeria during two seasons 2016 and 2017, then exposed to a green extraction. Total phenolic (TPC), flavonoid (FC) and condensed tannins (CTC) content were estimated spectrophotometrically. The antioxidant activity was measured using five different methods, DPPH., ABTS.+, FRAP, CUPRAC and Fe2+‐chelating. The results have revealed considerable amounts of TPC varied from 804 to 1544 mg GAE/100 g dry matter, FC started from 187 up to 410 mg QE/100 g dry matter and CTC varied from 111 to 394 mg CE/100 g dry matter. The best IC50 values (μg/mL) of DPPH., ABTS•+, FRAP, CUPRAC and Fe2+‐chelating tests were 56.62, 5.41, 21.26, 52.93 and 78.10, respectively. Moreover, high correlations were found between CTC and most of the antioxidant tests. Hence, CTC are suggested to be the principal group of antioxidant activity in Deverra scoparia Coss. & Durieu extracts.

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“…Some biological activities have been reported for the extract or essential oils of P . scoparius , such as antioxidant activity and antimicrobial activity. [ ][ ][ ][ ]…”

Section: Introductionmentioning

confidence: 99%

“…Both oils exhibited a composition dominated by monoterpene hydrocarbons: a-pinene (34.4% and 23.6%, respectively), sabinene (16.3% and 26.5%, respectively) and p-cymene (10.1% and 8.6%, respectively), but no phenylpropanoid derivatives were found. Ksouri et al [14] also investigated the composition of aerial parts oil sample isolated from plants harvested in March in Tamanrasset Province (Hoggar, southern Algeria). This oil sample was characterized by a high content of limonene (46.9%), followed by 1,8-cineole (7.6%).…”

Section: Introductionmentioning

confidence: 99%

Chemical Variability of the Essential Oil of Pituranthos scoparius from Algeria

Malti

Boussaïd

Belyagoubi

et al. 2018

Chemistry & Biodiversity

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The chemical composition of 93 oil samples from the aerial parts of Pituranthos scoparius, harvested in three regions of Algeria, was investigated by GC-FID, GC/MS and C-NMR. Monoterpene hydrocarbons dominated in association with phenylpropanoids and a chemical variability was found highlighting three clusters. The composition of group I (36 samples) exhibited an atypical composition characterized by a very high contents of 6-methoxyelemicine (13.0 - 59.6%), followed by sabinene (1.1 - 43.0%) and limonene (6.6 - 39.0%), while the samples of group II (12 samples) contained a high content of limonene (9.2 - 44.0%), followed by myristicine (0.0 - 29.4%) and a lower amount of sabinene (0.8 - 2.3%). Group III (45 samples) could be divided in two subgroups. Subgroup SGIIIA was characterized by a very high content of sabinene (28.0 - 55.6%), followed by elemicine (0.0 - 29.1%), while the samples belonging to SGIIIB were characterized by the lower content of sabinene (6.2 - 35.5%) and a significant content of myristicine (1.5 - 32.4%), α-pinene (4.2 - 31.0%) and dill apiole (0.1 - 31.4%). Each harvested region was characterized by a different chemical composition.

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Volatile compounds and biological activities of aerial parts of <i>Pituranthos scoparius</i> (Coss and Dur) Schinz (Apiaceae) from Hoggar, southern Algeria

Cited by 14 publications

References 14 publications

Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules

Heterometrus spinifer: An Untapped Source of Anti-Tumor Molecules

Effect of Seasonal and Regional Variations on Phenolic Compounds of Deverra scoparia (Flowers/Seeds) Methanolic Extract and the Evaluation of Its in Vitro Antioxidant Activity

Chemical Variability of the Essential Oil of Pituranthos scoparius from Algeria

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