Volatile composition, antioxidant activity, and antioxidant components in saffron cultivated in Turkey

Koşar, Müberra; Demirci, Betül; Göğer, Fatih; Kara, İzzet; Başer, K. H. C.

doi:10.1080/10942912.2017.1311341

Cited by 22 publications

(19 citation statements)

References 17 publications

(28 reference statements)

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“…Despite the highest amounts of picrocrocin and crocins being found in the sample of Hermel (Leb2), the saffron extract from Qaa (Leb1) was found to have the greatest values of total polyphenols, as well as strong free radical scavenging activity using ABTS and DPPH tests, similar to the Iranian sample and slightly more efficient. These observations are consistent with other studies presenting antiradical activity in the saffron extract [ 2 , 28 ]. To confirm the biological activity of samples, we evaluated their potential to induce a cytotoxic effect in lung cancer cells (A549).…”

Section: Discussionsupporting

confidence: 94%

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

et al. 2021

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Despite the beneficial health properties shown by Lebanese saffron, its qualitative and quantitative composition has never been investigated before. In the present study, NMR spectroscopy, together with antioxidant activity assays, were applied to evaluate the chemical composition of saffron samples of different geographical origins (Lebanon, Italy, Iran, and India) and to categorize the Lebanese saffron for the first time. The distinction between Lebanese saffron and that produced in other countries was attributed to its higher linolenic and linoleic fatty acids, glucose and picrocrocin contents. Moreover, spices produced in three different regions of the Lebanese territory have been clearly differentiated. Saffron cultivated in the Qaa region displayed a high glucose, fatty acids and polyphenols content, whereas Hermel saffron exhibited the largest rate of picrocrocin and glycosylated carotenoids. Finally, samples from Baalbeck showed lower rates for the majority of metabolites. Moreover, Lebanese saffron showed a high antioxidant activity in ABTS and DPPH assays. A low dose of saffron extract (10 µg/mL) inhibited the growth of human lung adenocarcinoma cells, probably due to the high polyphenolic content. This study highlights the quality and peculiarity of Lebanese saffron cultivated in Northern Beqaa district and allows for a good discrimination between spices produced in relatively close territory.

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Section: Discussionsupporting

confidence: 94%

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

et al. 2021

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“…Some studies have previously shown the antioxidant activity of saffron [11,21,22]. Crocin, picrocrocin, and safranal are bioactive constituents of C. sativus that show significant antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

“…Constituents such as crocin, picrocrocin, and safranal are the main compounds of saffron [10]. Several studies have demonstrated many pharmacological properties such as anti-oxidant [11,12], anti-inflammatory [13,14], antitumor [15], and antidepressant [16] in saffron. Boskabady [17], Byrami [18], and Feyzi [19] have shown that the saffron extract and specifically safranal increased the ratio of interferon-γ to interleukin-4, indicating their effect on T-helper 1/ T-helper 2 balance.…”

Section: Effectiveness Of a Crocus Sativus Extract On Burn Wounds In mentioning

confidence: 99%

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Alemzadeh

Oryan

2018

Planta Med

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is a spice with various pharmacological properties. Crocin, picrocrocin, and safranal are the main compositions of saffron that have recently been considered in the therapy of many diseases. High-performance liquid chromatography analysis revealed presence of these compounds in our saffron extract. This study was carried out to evaluate the effect of saffron on burn wound healing at an model. Saffron was topically applied on burn wounds in rats; the percentage of wound closure, wound contraction, and the levels of main cytokines and growth factors were measured. The saffron extract was also applied to evaluate the proliferation and migration of human dermal fibroblast (HDF) cells using scratch assay and resulted in active proliferation and migration of the HDF cells in a dose-dependent manner. A clear enhanced healing was observed in the saffron-treated wounds compared to the silver sulfadiazine and negative control groups. Decreased expression of interleukin-1 and transforming growth factor-1 (TGF-1) during the inflammatory phase demonstrated the role of saffron in promoting wound healing. In addition, enhanced TGF-1 expression during the proliferative phase and basic fibroblast growth factor during the remodeling phase represented regenerative and anti-scarring role of saffron, respectively. Our histological and biochemical findings also confirmed that saffron significantly stimulated burn wound healing by modulating healing phases. Therefore, saffron can be an optimal option in promoting skin repair and regeneration. Application of this herbal medicinal drug should be encouraged because of its availability and negligible side effects.

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“…13 Today, the secondary metabolites of saffron are determined by chromatographic methods. [14][15][16][17] Depending on the type of ingredients that make up the aroma, taste and colour of this plant, the types and methods of chromatography used are different. Carmona et al studied the flavonoid fraction in saffron by liquid chromatography coupled with diode array detection and electrospray ionisation tandem mass spectrometry (LC-DAD-ESI-MS/MS) and found five derivatives of kaempferol.…”

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confidence: 99%

“…These materials were then simultaneously analysed by gas chromatographic coupled with mass spectrometry (GC-MS). 15 Although the effect of sound waves on seed germination of plants or their aerial parts (growth) has been studied, no information is available about the effect of acoustic sound waves on the corms of plants especially saffron as well as the content of their major secondary metabolites of saffron (i.e. crocin, picrocrocin and safranal), which are responsible for the organoleptic properties of saffron.…”

mentioning

confidence: 99%

Quantification of crocin, picrocrocin and safranal in saffron stigmas obtained from sounded corms with acoustic waves

Razavizadeh¹,

Delooei

2021

Phytochemical Analysis

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Introduction: Plant acoustic frequency technology (PAFT) is the effect or treatment of a plant with a specific frequency sound wave.Objective: The sound waves with different frequencies and a sound pressure level 77 dB were emitted on the saffron corms in a controlled environment using aeroponic cultivation and the contents of crocin, picrocrocin and safranal in their produced stigmas were analysed by high-performance liquid chromatography. For this purpose, the corms were divided into two groups. In group 1, sound waves with the frequencies of 0.5, 1 and 2 kHz were emitted on saffron corms in different stages of sprouting, flowering and the whole stage of sprouting and flowering. In group 2, sonication was performed on the corms during the flowering stage at 4, 8, 12 and 16 kHz frequencies. Results:The changes in the contents of crocin, picrocrocin and safranal were not significantly compared to the control at 0.5, 1 and 2 kHz frequencies in the stages of sprouting and flowering of corms. While the higher frequencies (4, 8, 12 and 16 kHz) in flowering stage were affected significantly, the crocin and picrocrocin content increased 8.5% and 30%, applying the frequency of 12 and 8 kHz, respectively. Also, the effect of sound exposure time per day with the frequency of 16 kHz at 15, 30 and 60 min were investigated. Conclusion:The findings showed that the corms could be affected by sounding in the different stages of growth of the corm and also in the content of secondary metabolites.

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Volatile composition, antioxidant activity, and antioxidant components in saffron cultivated in Turkey

Cited by 22 publications

References 17 publications

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon

Effectiveness of a Crocus sativus Extract on Burn Wounds in Rats

Quantification of crocin, picrocrocin and safranal in saffron stigmas obtained from sounded corms with acoustic waves

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