Volatile biomarkers of pulmonary tuberculosis in the breath

Phillips, Michael; Cataneo, Renee N.; Condos, Rany; Erickson, Gerald A. Ring; Greenberg, Joel; Bombardi, Vincent La; Munawar, Muhammad I.; Tietje, Olaf

doi:10.1016/j.tube.2006.03.004

Cited by 282 publications

(219 citation statements)

References 16 publications

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“…In addition, they studied the potential of VOCs to differentiate between 42 patients with a suspicion of pulmonary tuberculosis and 59 controls, and tuberculosis patients with and without bacterial sputum colonization. These classifications were possible with high sensitivity and specificity (20).…”

Section: Discussionmentioning

confidence: 99%

Metabolomics of Volatile Organic Compounds in Cystic Fibrosis Patients and Controls

et al. 2010

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ABSTRACT:In cystic fibrosis (CF), airway inflammation causes an increased production of reactive oxygen species, responsible for degradation of cell membranes. During this process, volatile organic compounds (VOCs) are formed. Measurement of VOCs in exhaled breath of CF patients may be useful for the assessment of airway inflammation. This study investigates whether "metabolomics' of VOCs could discriminate between CF and controls, and between CF patients with and without Pseudomonas colonization. One hundred five children (48 with CF, 57 controls) were included in this study. After exhaled breath collection, samples were transferred onto tubes containing active carbon to adsorb and stabilize VOCs. Samples were analyzed by gas chromatography-time of flight-mass spectrometry to assess VOC profiles. Analysis showed that 1099 VOCs had a prevalence of at least 7%. By using 22 VOCs, a 100% correct identification of CF patients and controls was possible. With 10 VOCs, 92% of the subjects were correctly classified. The reproducibility of VOC measurements with a 1-h interval was very good (match factor 0.90 Ϯ 0.038). We conclude that metabolomics of VOCs in exhaled breath was possible in a reproducible way. This new technique was able to discriminate not only between CF patients and controls but also between CF patients with or without Pseudomonas colonization. (Pediatr Res 68: 75-80, 2010)

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Section: Discussionmentioning

confidence: 99%

Metabolomics of Volatile Organic Compounds in Cystic Fibrosis Patients and Controls

et al. 2010

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“…We have previously reported that biomarkers in the breath predict lung cancer [3,4], breast cancer [5], pulmonary tuberculosis [6], and heart transplant rejection [7]. All of these tests assigned a relative weight to a number of different biomarkers -volatile organic compounds (VOCs) in the breath -and incorporated them into a predictive algorithm with a binary outcome i.e.…”

Section: Introductionmentioning

confidence: 99%

Detection of lung cancer using weighted digital analysis of breath biomarkers

Phillips

Altorki

Austin

et al. 2008

Clinica Chimica Acta

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“…The approach is based on the detection of volatile organic compounds (VOCs) that are emitted from infected cells and released in exhaled breath [8,9]. Using gas chromatography linked with mass spectrometry, researchers have previously reported identification of TB-related VOCs in the exhaled breath, though there has been low accuracy in detection (80-85%) [10]. In this study, we explore the possibility of active TB detection via the analysis of exhaled breath using a novel technology of organically modified nanomaterial-based sensors.…”

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confidence: 99%