Volatile Anesthetics Augment Expression of Proinflammatory Cytokines in Rat Alveolar Macrophages during Mechanical Ventilation

Kotani, Naoki; Takahashi, Satoshi; Sessler, Daniel I.; Hashiba, Eiji; Kubota, Takeshi; Hashimoto, Hiroshi; Matsuki, Akitomo

doi:10.1097/00000542-199907000-00027

Cited by 112 publications

(65 citation statements)

References 31 publications

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“…46,47 In fact, mechanical ventilation might attenuate or reverse the protective potential of volatile anesthetics. 48 Moreover, preconditioning might also be model dependent. For example, volatile anesthetics have been shown to aggravate acid-induced lung injury.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Isoflurane Pretreatment in Endotoxin-induced Lung Injury

Reutershan

Chang

Hayes³

et al. 2006

Anesthesiology

126

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Background:The concept of antiinflammatory effects of volatile anesthetics is well established in vitro and in some organ systems. Their protective role in lung injury, however, remains to be elucidated. The authors hypothesized that in the lung, isoflurane pretreatment may attenuate neutrophil infiltration and reduce endotoxin-induced injury.Methods: Male C57Bl/6 mice were exposed to aerosolized lipopolysaccharide. Neutrophil recruitment into the pulmonary vasculature and migration into the different lung compartments (interstitium and alveolar air space) were determined by flow cytometry. Capillary protein leakage, formation of lung edema, and concentration of the chemokines keratinocyte-derived chemokine (CXCL1) and macrophage inflammatory protein 2 (CXCL2/3) in bronchoalveolar lavage were compared in mice with or without isoflurane treatment (1.4% inspired for 30 min) at different times before and after endotoxin exposure.Results: Endotoxin inhalation induced significant neutrophil migration into all lung compartments. Isoflurane pretreatment attenuated both neutrophil recruitment into lung interstitium and alveolar space when given 1 or 12 h before or 1 h after lipopolysaccharide but not at 4, 6, or 24 h before endotoxin exposure. Isoflurane pretreatment 1 or 12 h before lipopolysaccharide also reduced protein leakage and pulmonary edema. Production of CXCL1 and CXCL2/3 in the bronchoalveolar lavage was reduced when isoflurane was given 1 h but not 12 h before lipopolysaccharide, suggesting different mechanisms for early and late protection.Conclusion: Isoflurane pretreatment reduces acute lung injury when given 1 or 12 h before an endotoxin challenge or within the first hour of an already established inflammation.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Isoflurane Pretreatment in Endotoxin-induced Lung Injury

Reutershan

Chang

Hayes³

et al. 2006

Anesthesiology

126

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“…Makrofaj agregasyondaki artış, izofluran anestezisinde propofol anestezisine göre anlamlı derecede yüksek olduğunu saptamışlardır. Aynı ekibin yaptığı bir sonraki çalışmada, 1,5 MAC volatil anestezik uygulanan ratlarda 2 saatlik anestezi ve cerrahi sonunda halotan, enfluran ve izofluran uygulanan gruplarda pulmoner lavaj sıvısındaki macrophage inflammatory protein-2 (MIP-2) düzeyi anlamlı derecede yüksek bulunmuş-tur [8] . MIP-2'nin distal hava yolunda nötrofiller için en güçlü kemoatraktanlardan biri olduğu bilinmektedir.…”

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

“…Grup S, Grup İ ile karşılaştırıldığında alveoler ödem, alveoler septumlarda kalınlaşma, nötrofil ve tip II pnömositler daha az miktarda gözlendi (Resim 2, 3,4,8,9,10). Alveoler makrofaj sayısı ise Grup S de Grup İ ye göre istatistiksel olarak anlamlı miktarda azdı (Tablo 3) Parankim incelemesinde, Grup İ'de yoğun olarak görülen yaygın hemoraji, mononükleer hüc-re infiltrasyonu, ödem ve vasküler konjesyon daha az oranda saptandı (Resim 2, 3, 4, 8, 9, 10).…”

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

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Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Acıl¹,

Kaçar²,

Uzundere³

et al. 2018

GKDA Derg

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“…Thus, general anesthesia (i.e., volatile anesthetics) may impair immunologic defense mechanisms inducing an inflammatory reaction in the macrophages. [11][12][13] The clinical consequences of oxidative stress of ischemia and reperfusion during laparoscopic procedures have not yet been clearly elucidated. 14,15 Thus, patients with gallstones might be exposed to oxidative stress due to the chronic pattern of the disease, pneumoperitonium during laparoscopic surgery and general anesthesia with volatile anesthetics, which might have significant clinical effects especially in patients with co-morbidities.…”

mentioning

confidence: 99%

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Yalçın¹,

Aydoğan²,

Serdaroğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study aimed to investigate the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and the paraoxonase and arylesterase activities of patients with gallstones and compare them with healthy individuals as well as to assess the impact of sevoflurane and desflurane on oxidative stress markers in laparoscopic surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty patients scheduled for laparoscopic surgery (Patient Group) and 30 healthy volunteers as control subjects (Control Group) were enrolled in the study. The patient group was randomized to desflurane group (n= 0) and sevoflurane group (n= 20). Blood samples were collected preoperatively and at postoperative 6 hours in order to measure the levels of TAS, TOS, OSI, and paraoxonase and arylesterase activities. Preoperative and postoperative laboratory findings of sevoflurane and desflurane group were compared with the Mann Whitney U test between groups and the Wilcoxon test within a group. R Re es su ul lt ts s: : Preoperative TOS, OSI levels in the patient group were significantly increased and arylesterase activities were significantly decreased compared to the control group (p<0.05) [(TOS (µmol H2O2 equiv/L), 19.64 ± 2.16 vs. 14.25 ± 1.83), (OSI 1.85 ± 0.53 vs. 0.98 ± 0.24), (Arylesterase (U/L), 45.19 ± 6.82 vs. 49.66 ± 4.78)]. There was no statistically significant difference between sevoflurane and desflurane group in laboratory findings of the preoperative and the postoperative period (p> 0.05). Preoperative and postoperative TAS, TOS, OSI results and activities of paraoxonase and arylesterase were not significantly different in the sevoflurane group (p> 0.05). Although the preoperative and postoperative levels of TAS and TOS and paraoxonase and arylesterase activities in the desflurane group was not significantly different, postoperative OSI was significantly increased (p< 0.05) (OSI 1.80 ± 0.57 vs 2.20 ± 0.67). C Co on nc cl lu us si io on n: : Patients with gallstone are exposed to a potent oxidative stress influencing TOS, OSI levels and arylesterase activities. Sevoflurane and desflurane had similar effects on oxidative stress during laporoscopic surgery in this patient group; however, OSI was increased in the desflurane group in the postoperative period compared to preoperative levels (p< 0.05).K Ke ey y W Wo or rd ds s: : Gallstones; laparoscopy; sevoflurane; desflurane; oxidative stress Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada, safra taşı olan hastalarda total oksidan seviye (TOS), total antioksidan seviye (TAS), oksidatif stres indeksi (OSİ) seviyelerinin ve paraoksonaz, arilesteraz aktivitelerinin, sağlıklı bireylerdeki parametrelerle karşılaştırılması ve laparoskopik cerrahide oluşan oksidatif stres üzerinde sevofluran ve desfluranın etkilerinin araştırılması amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Laparoskopik cerrahi planlanan 40 hasta (hasta grubu) ve 30 sağlıklı gönüllü (kontrol grubu) çalışmaya dâhil...

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Volatile Anesthetics Augment Expression of Proinflammatory Cytokines in Rat Alveolar Macrophages during Mechanical Ventilation

Abstract: Gene expression of proinflammatory cytokines increase after inhalation of volatile anesthetics under mechanical ventilation. These data indicate that inhalation of volatile anesthetics under mechanical ventilation induces an inflammatory response at the transcriptional level within 2 h.

Cited by 112 publications

References 31 publications

Protective Effects of Isoflurane Pretreatment in Endotoxin-induced Lung Injury

Protective Effects of Isoflurane Pretreatment in Endotoxin-induced Lung Injury

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

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