Voice rehabilitation for laryngeal cancer after radiotherapy: a systematic review and meta-analysis

Taito, Mahoko; Taito, Shunsuke; Banno, Masahiro; Fujiwara, Takashi; Okamura, Hitoshi; Tsujimoto, Hiraku; Kataoka, Yuki; Tsujimoto, Yasushi

doi:10.1007/s00405-019-05452-2

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…The management of cancer mainly involves surgery, radiotherapy, chemotherapy, and the rapidly evolving field immunotherapy 8 . The most commonly used cancer therapies over the past century include chemotherapy and radiotherapy methods [9][10][11][12] ; among these, radiotherapy is widely and predominantly used prior to surgery and other treatment methods 13,14 . Radiotherapy is defined as the application of radiation for clinical cancer treatment, including external-beam radiation and local radioactive seed implants with the purpose of killing cancer cells or controlling cancer cell proliferation 15,16 .…”

Section: Introductionmentioning

confidence: 99%

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Huang

Zhou

2020

Sig Transduct Target Ther

599

457

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Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications. Efforts are continuously ongoing to explore sensitizing targets and develop radiosensitizers for improving the outcomes of radiotherapy. DNA double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses (DDRs), including those helping cells recover from radiation injuries, such as the activation of DNA damage sensing and early transduction pathways, cell cycle arrest, and DNA repair. Obviously, these protective DDRs confer tumor radioresistance. Targeting DDR signaling pathways has become an attractive strategy for overcoming tumor radioresistance, and some important advances and breakthroughs have already been achieved in recent years. On the basis of comprehensively reviewing the DDR signal pathways, we provide an update on the novel and promising druggable targets emerging from DDR pathways that can be exploited for radiosensitization. We further discuss recent advances identified from preclinical studies, current clinical trials, and clinical application of chemical inhibitors targeting key DDR proteins, including DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), ATM/ATR (ataxia-telangiectasia mutated and Rad3-related), the MRN (MRE11-RAD50-NBS1) complex, the PARP (poly[ADP-ribose] polymerase) family, MDC1, Wee1, LIG4 (ligase IV), CDK1, BRCA1 (BRCA1 C terminal), CHK1, and HIF-1 (hypoxia-inducible factor-1). Challenges for ionizing radiation-induced signal transduction and targeted therapy are also discussed based on recent achievements in the biological field of radiotherapy.

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Section: Introductionmentioning

confidence: 99%

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Huang

Zhou

2020

Sig Transduct Target Ther

599

457

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“…These studies have provided a better road map towards multi-classification among LC cases. But, no specific voice rehabilitation was found to be necessary for laryngeal cancer patients after radiotherapy as there was no statistical significance found with these parameters [10].…”

Section: Background Studymentioning

confidence: 98%

“…But, this PDM modeling was done using neural maps which was quite complex and time consuming with increased number of iterations. Moreover, efforts have been made to preserve the larynx after surgery, radiotherapy, and rehabilitation [10]. It is clear from the previous studies that,…”

Section: Introductionmentioning

confidence: 99%

Voice-Disorder Identification of Laryngeal Cancer Patients

Gour¹,

Udayashankara²,

Badakh³

et al. 2020

IJACSA

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This Previous studies have shown that much of laryngeal cancer-based work was carried out with a minimal set of linear features. Much of the work was focused on the study of larynx preservation, quality of life around radiotherapy, or surgery. The voice disorder database was not solely limited to laryngeal cancer. In the context of this, the paper proposes a noninvasive voice disorder detection of laryngeal cancer patients. The sustained vowel /a/ was recorded with 55 laryngeal cases and 55 healthy cases. Owing to the non-linearity property of the vocal cords, seven non-linear parameters along with biologically inspired 39 Mel-Frequency Cepstral Coefficients (MFCC) are extracted. This forms a laryngeal dataset of size 110X46. The wrapper method is used for better feature selection and to enhance the discriminating ability of the present work. The classification is carried out using a tuned support vector machine (SVM) with grid search and random forest (RF). The present work has shown an improved accuracy of 76.56% with SVM and 80% in the case of random forest. The forward selection of features along with the involvement of non-linear features has played a significant role in the better performance of the present system.

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“…The latter aims to improve the flexibility of the larynx and to maximise phonation and articulation. Nonetheless, mixed data has been published regarding its effectiveness in treating speech impairments [195,[200][201][202]. In addition, multiple methods of surgical voice rehabilitation have been reported to ameliorate dysphonia in case reports [203,204].…”

Section: Dysphagia and Dysphoniamentioning

confidence: 99%

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Azzam¹,

Mroueh²,

Francis³

et al. 2020

ecancer

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Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Despite the substantial advances in RT contouring and dosage delivery, patients suffer from various radiation-induced complications, among which are toxicities to the nervous tissues in the head and neck area. Radiation-mediated neuropathies manifest as a result of increased oxidative stress-mediated apoptosis, neuroinflammation and altered cellular function in the nervous tissues. Eventually, molecular damage results in the formation of fibrotic tissues leading to susceptible loss of function of numerous neuronal substructures. Neuropathic sequelae following irradiation in the head and neck area include sensorineural hearing loss, alterations in taste and smell functions along with brachial plexopathy, and cranial nerves palsies. Numerous management options are available to relieve radiation-associated neurotoxicities notwithstanding treatment alternatives that remain restricted with limited benefits. In the scope of this review, we discuss the use of variable management and therapeutic modalities to palliate common radiation-induced neuropathies in head and neck cancers.

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Voice rehabilitation for laryngeal cancer after radiotherapy: a systematic review and meta-analysis

Cited by 14 publications

References 13 publications

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Voice-Disorder Identification of Laryngeal Cancer Patients

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

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